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Cat. No.: HY-N18018

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Tetrahydroswertianolin

Tetrahydroswertianolin (Compound 1) is a tetrahydroxyxanthone glycoside that can be isolated from the whole plant of Swertia japonica Makino. Tetrahydroswertianolin reduces the elevated blood ALT levels in mice with immune-induced liver injury and exhibits protective activity against liver injury. Tetrahydroswertianolin can be used in studies related to anthelmintic, antipyretic and immune-induced liver injury.

For research use only. We do not sell to patients.

CAS No.: 189289-76-7
Formula: C₂₀H₂₄O₁₁
Molecular Weight:440.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Tetrahydroswertianolin Chemical Structure

CAS No.: 189289-76-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Tetrahydroswertianolin (Compound 1) (25-50 mg/kg, s.c., single administration) reduces blood ALT levels and exhibits significant, dose-dependent hepatoprotective effects in a mouse liver injury model induced by D-galactosamine and LPS (HY-D1056)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

mice^[1]
Dosage:

25, 50 mg/kg
Administration:

s.c., once
Result:

Reduced blood ALT levels and exhibited significant, dose-dependent hepatoprotective effects.

Chemical Information

CAS No. 189289-76-7
Molecular Weight 440.40
Formula C₂₀H₂₄O₁₁
SMILES

O=C(C([C@H]1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=C([C@@H](CC1)O)OC3=CC(OC)=C4)C3=C4O
Structure Classification
- Phenols
- Xanthones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koji HASE, et al. TETRAHYDROSWERTIANOLIN : A POTENT HEPATOPROTECTIVE AGENT FROM SWERTIA JAPONICA MAKINO. Chem. Pharm. Bull. 45(3) 567-569 (1997)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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