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  3. Drug Derivative
  4. Tetrahydroswertianolin

Tetrahydroswertianolin (Compound 1) is a tetrahydroxyxanthone glycoside that can be isolated from the whole plant of Swertia japonica Makino. Tetrahydroswertianolin reduces the elevated blood ALT levels in mice with immune-induced liver injury and exhibits protective activity against liver injury. Tetrahydroswertianolin can be used in studies related to anthelmintic, antipyretic and immune-induced liver injury.

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Tetrahydroswertianolin

Tetrahydroswertianolin Chemical Structure

CAS No. : 189289-76-7

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Tetrahydroswertianolin Related Antibodies

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Description

Tetrahydroswertianolin (Compound 1) is a tetrahydroxyxanthone glycoside that can be isolated from the whole plant of Swertia japonica Makino. Tetrahydroswertianolin reduces the elevated blood ALT levels in mice with immune-induced liver injury and exhibits protective activity against liver injury. Tetrahydroswertianolin can be used in studies related to anthelmintic, antipyretic and immune-induced liver injury[1].

In Vivo

Tetrahydroswertianolin (Compound 1) (25-50 mg/kg, s.c., single administration) reduces blood ALT levels and exhibits significant, dose-dependent hepatoprotective effects in a mouse liver injury model induced by D-galactosamine and LPS (HY-D1056)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mice[1]
Dosage: 25, 50 mg/kg
Administration: s.c., once
Result: Reduced blood ALT levels and exhibited significant, dose-dependent hepatoprotective effects.
Molecular Weight

440.40

Formula

C20H24O11
CAS No.
SMILES

O=C(C([C@H]1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)=C([C@@H](CC1)O)OC3=CC(OC)=C4)C3=C4O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Tetrahydroswertianolin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydroswertianolin189289-76-7Drug DerivativeDrug derivativetetrahydroxyxanthone glycosideSwertia japonica Makinoliver injurymice
Inhibitorinhibitorinhibit

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