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Nostoc

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By Targets:	Autophagy (1) Bacterial (1) Endogenous Metabolite (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) Phytohormone (1) PI3K (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (3) Infection (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134200

1-Palmitoyl-2-oleoyl-sn-glycerol	Endogenous Metabolite	Others
1-Palmitoyl-2-oleoyl-sn-glycerol is a diacylglycerol hormogonium inducer that can be isolated from the coralloid roots of Cycas revoluta. 1-Palmitoyl-2-oleoyl-sn-glycerol promotes the differentiation of filamentous Nostoc cell aggregates into motile hormogonia, and further induces the formation of dense bundle-like structures. 1-Palmitoyl-2-oleoyl-sn-glycerol is not only commonly used as a diacylglycerol standard, but also can effectively identify and separate glycerophosphate-containing phospholipid enantiomers after acetylation. 1-Palmitoyl-2-oleoyl-sn-glycerol is also used to study cyanobacterial developmental mechanisms and lipid analysis .

HY-W011151

trans-Zeatinriboside 1 Publications Verification	Phytohormone	Others
trans-Zeatinriboside is a zeatin-type cytokinin and plant growth regulator. trans-Zeatinriboside is produced by the terrestrial filamentous cyanobacterium Nostoc sp. HK-01 and Agrobacterium tumefaciens (including Ti plasmid-dependent and Ti plasmid-independent strains). trans-Zeatinriboside is detectable as a cytokinin component in growing crown galls, and accumulates in large amounts in CHRK1-silenced transgenic tobacco accompanied by pleiotropic developmental abnormalities. trans-Zeatinriboside can be used in studies related to crown galls .

HY-N15346

Menominin B	Others	Cancer
Menominin B is a cyclic peptide found in the freshwater sponge-associated cyanobacterium Nostoc sp. with cytotoxic properties. Menominin B exhibits antiproliferative activity against the ovarian cancer cell line OVCAR3 (with IC₅₀ of 2.4 μM). Menominin B holds promise for research in the field of anticancer therapy .

HY-N15353

1-Palmitoyl-2-linoleoyl-sn-glycerol	Bacterial	Infection
1-Palmitoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DAG)-type lipid signaling molecule found in the coralloid roots of Cycas revoluta, and serves as a major active component of the plant-secreted hormogonium-inducing factor (HIF). At a concentration of 1 nmol/disc (approximately 0.6 µg), 1-palmitoyl-2-linoleoyl-sn-glycerol can significantly induce the differentiation of filamentous aggregates of Nostoc into motile hormogonia, thereby promoting chemotaxis toward host roots and the establishment of symbiosis. This compound holds significant research and application potential in areas such as plant–microbe interactions, rhizosphere signaling pathways, and nitrogen-fixing symbiosis .

HY-N15345

Menominin A	Others	Cancer
Menominin A is a cyclic peptide identified from the freshwater sponge-associated cyanobacterium Nostoc sp., exhibiting cytotoxic properties. It displays antiproliferative activity against the ovarian cancer cell line OVCAR3, with an IC₅₀ value of 3.1 μM. Menominin A holds promise for research in the field of anticancer therapeutics .

HY-182236

JRN73958 Reduced scytonemin	PI3K p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS) Autophagy	Cancer
JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-134200

1-Palmitoyl-2-oleoyl-sn-glycerol	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
1-Palmitoyl-2-oleoyl-sn-glycerol is a diacylglycerol hormogonium inducer that can be isolated from the coralloid roots of Cycas revoluta. 1-Palmitoyl-2-oleoyl-sn-glycerol promotes the differentiation of filamentous Nostoc cell aggregates into motile hormogonia, and further induces the formation of dense bundle-like structures. 1-Palmitoyl-2-oleoyl-sn-glycerol is not only commonly used as a diacylglycerol standard, but also can effectively identify and separate glycerophosphate-containing phospholipid enantiomers after acetylation. 1-Palmitoyl-2-oleoyl-sn-glycerol is also used to study cyanobacterial developmental mechanisms and lipid analysis .

HY-W011151

trans-Zeatinriboside 1 Publications Verification	Structural Classification Classification of Application Fields Plants Cytokinin Catharanthus roseus (L.) G. Don Agricultural Research Apocynaceae Alkaloids Other Alkaloids Other Diseases Phytohormone Disease Research Fields Source Classification	Phytohormone
trans-Zeatinriboside is a zeatin-type cytokinin and plant growth regulator. trans-Zeatinriboside is produced by the terrestrial filamentous cyanobacterium Nostoc sp. HK-01 and Agrobacterium tumefaciens (including Ti plasmid-dependent and Ti plasmid-independent strains). trans-Zeatinriboside is detectable as a cytokinin component in growing crown galls, and accumulates in large amounts in CHRK1-silenced transgenic tobacco accompanied by pleiotropic developmental abnormalities. trans-Zeatinriboside can be used in studies related to crown galls .

HY-N15346

Menominin B	Natural Products Microorganisms Source Classification	Others
Menominin B is a cyclic peptide found in the freshwater sponge-associated cyanobacterium Nostoc sp. with cytotoxic properties. Menominin B exhibits antiproliferative activity against the ovarian cancer cell line OVCAR3 (with IC₅₀ of 2.4 μM). Menominin B holds promise for research in the field of anticancer therapy .

HY-N15353

1-Palmitoyl-2-linoleoyl-sn-glycerol	Structural Classification Plants Cycadaceae Cycas revoluta Thunb. Lipid Source Classification	Bacterial
1-Palmitoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DAG)-type lipid signaling molecule found in the coralloid roots of Cycas revoluta, and serves as a major active component of the plant-secreted hormogonium-inducing factor (HIF). At a concentration of 1 nmol/disc (approximately 0.6 µg), 1-palmitoyl-2-linoleoyl-sn-glycerol can significantly induce the differentiation of filamentous aggregates of Nostoc into motile hormogonia, thereby promoting chemotaxis toward host roots and the establishment of symbiosis. This compound holds significant research and application potential in areas such as plant–microbe interactions, rhizosphere signaling pathways, and nitrogen-fixing symbiosis .

HY-N15345

Menominin A	Microorganisms Cyclopeptides Source Classification	Others
Menominin A is a cyclic peptide identified from the freshwater sponge-associated cyanobacterium Nostoc sp., exhibiting cytotoxic properties. It displays antiproliferative activity against the ovarian cancer cell line OVCAR3, with an IC₅₀ value of 3.1 μM. Menominin A holds promise for research in the field of anticancer therapeutics .

HY-182236

JRN73958 Reduced scytonemin	Structural Classification Alkaloids Microorganisms Other Alkaloids Source Classification	PI3K p38 MAPK NF-κB NO Synthase Reactive Oxygen Species (ROS) Autophagy
JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Nostoc

Inhibitors & Agonists

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Natural
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