23576-23-0
Chemical Structure
Metflurazon
Synonym(s): SAN 6706
- CAS No.: 23576-23-0
- Formula:C13H11ClF3N3O
- Molecular Weight:317.69
IUPAC Name: 4-chloro-5-(dimethylamino)-2-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one
InChIKey: CYQMVKQKBFFDOO-UHFFFAOYSA-N
SMILES: O=C1C(Cl)=C(C=NN1C2=CC=CC(C(F)(F)F)=C2)N(C)C
Biological Activity: Metflurazon (SAN 6706) is a pro-herbicide that acts as a substrate for cytochrome P450 monooxygenase. Metflurazon undergoes sequential N-demethylation to form Norflurazon (HY-114849), which in turn exerts anti-cyanobacterial activity. Metflurazon inhibits cyclic photophosphorylation, growth, heterocyst formation, and exogenous ATP transport in cyanobacteria, reduces their survival rate, and induces a methylamine-like effect. Metflurazon can be used in studies related to herbicides and cyanobacteria[1][2].
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Metflurazon | Metflurazon (SAN 6706) is a pro-herbicide that acts as a substrate for cytochrome P450 monooxygenase. Metflurazon undergoes sequential N-demethylation to form Norflurazon (HY-114849), which in turn exerts anti-cyanobacterial activity. Metflurazon inhibits cyclic photophosphorylation, growth, heterocyst formation, and exogenous ATP transport in cyanobacteria, reduces their survival rate, and induces a methylamine-like effect. Metflurazon can be used in studies related to herbicides and cyanobacteria. | |||||||||||||||||||||
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References
- [1]. Thies F, et al. Xenobiotic biotransformation in unicellular green algae (Involvement of Cytochrome P450 in the activation and selectivity of the pyridazinone pro-herbicide metflurazon). Plant Physiology, 1996, 112(1): 361-370.
- [2]. Vaishampayan A, et al. A cyanobacterial mutant resistant against a bleaching herbicide. Journal of basic microbiology. 2000;40(4):279-88. [Content Brief]
