108 Results for "

PD-1/PD-L1-IN 5 TFA

" in MedChemExpress (MCE) Product Catalog:
Products (108)

108 Results for "PD-1/PD-L1-IN 5 TFA" in MCE Product Catalog:

258
258 Publications Verification
Cat. No.: HY-13948B
CAS No.: 2761969-44-0
Pureté:  98.84%
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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34
34 Cited Publications
Cat. No.: HY-15176B
CAS No.: 1472611-44-1
Pureté:  99.54%
Synonyms: RR82 TFA
Domaines de recherche:  

Cancer

Pyridostatin (RR82) TFA is a G-quadruplex (G4) inducer/stabilizer with a Kd of 490 nM. Pyridostatin TFA also acts as an inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 11.0 μM. Pyridostatin TFA interacts with G-quadruplex structures, regulates the expression of SRC and SUB1, and induces replication- and transcription-dependent DNA damage, growth arrest, and genomic instability. Pyridostatin TFA exhibits antiproliferative and antiviral activities. Pyridostatin TFA can be used in studies related to breast cancer, cervical cancer, and Zika virus infection .
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8
8 Cited Publications
Cat. No.: HY-P3211A
Synonyms: LR12 TFA
Nangibotide TFA (LR12 TFA) is a synthetic peptide and TREM-1 receptor inhibitor. Nangibotide TFA inhibits NF-κB and NLRP3 inflammasome activation and reduces the release of pro-inflammatory factors (such as IL-1β, IL-8). Nangibotide TFA inhibits Apoptosis. Nangibotide TFA reduces excessive inflammatory responses and protects tissues (liver, lung) from damage. Nangibotide TFA can be used in the researches for myocardial ischemia-reperfusion injury, septic shock, acute lung injury, osteoarthritis, and acute liver failure .
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6
6 Cited Publications
Cat. No.: HY-145514
CAS No.: 2624313-15-9
Pureté:  99.97%
Target:  

PROTACs FKBP

Domaines de recherche:  

Cancer

dTAGV-1 TFA is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 TFA induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 TFA is applicable to functional validation studies of cancer and undegradable oncoproteins .
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6
6 Cited Publications
Cat. No.: HY-13682C
Pureté:  ≥98.0%
Synonyms: MTP-PE TFA; L-MTP-PE TFA; CGP 19835 TFA
Domaines de recherche:  

Inflammation/Immunology Cancer

Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide TFA has potential for use in rare disease and osteosarcoma research .
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4
4 Cited Publications
Cat. No.: HY-111174A
CAS No.: 209248-71-5
Pureté:  99.62%
Synonyms: Ile-Pro-Ile TFA
Target:  

Dipeptidyl Peptidase

Domaines de recherche:  

Metabolic Disease

Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) .
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3
3 Cited Publications
Cat. No.: HY-108742A
Pureté:  99.86%
Synonyms: BA 058 TFA; BIM 44058 TFA
Target:  

Arrestin PTHR

Domaines de recherche:  

Metabolic Disease Endocrinology Cancer

Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis .
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3
3 Cited Publications
Cat. No.: HY-P0197A
CAS No.: 2828433-19-6
Synonyms: Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA
Target:  

Neurokinin Receptor

Domaines de recherche:  

Neurological Disease Endocrinology

Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .
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3
3 Cited Publications
Cat. No.: HY-P3400A
Synonyms: LQVTDSGLYRCVIYHPP TFA
Target:  

Inhibitory Antibodies

Domaines de recherche:  

Neurological Disease

LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 TFA substantially alleviates ischemia-induced infarction and neuronal injury. LP17 TFA can get access into brain and block TREM-1 .
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3
3 Cited Publications
Cat. No.: HY-P1022A
Synonyms: Metastin(human) TFA
Target:  

GnRH Receptor

Domaines de recherche:  

Endocrinology Cancer

Kisspeptin-54(human) TFA (Metastin(human) TFA) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) TFA binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) TFA hinders tumor metastasis and stimulates gonadotropin secretion .
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2
2 Cited Publications
Cat. No.: HY-P1925A
CAS No.: 1222186-26-6
Domaines de recherche:  

Cancer

GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .
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2
2 Cited Publications
Cat. No.: HY-19884B
CAS No.: 2863659-22-5
Synonyms: RM-131 TFA; BIM-28131 TFA
Target:  

GHSR

Domaines de recherche:  

Metabolic Disease

Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research .
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2
2 Cited Publications
Cat. No.: HY-P1682A
Synonyms: POL6326 TFA
Target:  

CXCR Arrestin

Domaines de recherche:  

Cancer

Balixafortide TFA (POL6326 TFA) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM. Balixafortide TFA shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux with IC50s < 10 nM. Balixafortide TFA is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects .
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2
2 Cited Publications
Cat. No.: HY-P1675A
Synonyms: AcPHF6 TFA; Ac-VQIVYK-NH2 TFA
Target:  

Tau Protein

Domaines de recherche:  

Neurological Disease

Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau derived hexapeptide.
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2
2 Cited Publications
Cat. No.: HY-P1676A
Synonyms: BK-1361 TFA
Target:  

MMP

Domaines de recherche:  

Cancer

cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer .
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1
1 Cited Publications
Cat. No.: HY-P1149A
Synonyms: Epithalon TFA; Epithalamin TFA
Target:  

Telomerase

Domaines de recherche:  

Neurological Disease Cancer

Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa .
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1
1 Cited Publications
Cat. No.: HY-106373A
Pureté:  99.85%
Synonyms: ACTH TFA; Adrenocorticotrophic hormone TFA
Adrenocorticotropic hormone (ACTH; Adrenocorticotrophic hormone) TFA is a polypeptide tropic hormone produced by the anterior pituitary gland. Adrenocorticotropic hormone TFA stimulates cortisol secretion from the adrenal cortex via the hypothalamic-pituitary-adrenal (HPA) axis. Adrenocorticotropic hormone TFA regulates cortisol and androgen production. Adrenocorticotropic hormone TFA can promote the development of spermatogenesis. Adrenocorticotropic hormone TFA can relieve acute inflammation in gout models by inhibiting the polarization of macrophages to M1 type, inhibiting ROS and proinflammatory factor production and protecting mitochondrial function. Adrenocorticotropic hormone TFA can be used for the researches of inflammation, endocrinology, metabolic disease, such as gout and nephrotic syndrome .
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1
1 Cited Publications
Cat. No.: HY-158102A
Synonyms: ORIC-944 TFA
Domaines de recherche:  

Cancer

Rinzimetostat (ORIC-944) TFA is the TFA salt form of ORIC (HY-158102). Rinzimetostat TFA is a selective, orally active, allosteric inhibitor targeting the EED subunit of polycomb repressive complex 2 (PRC2). Rinzimetostat TFA is synergistic with androgen receptor pathway inhibitors (ARPIs) for the study of metastatic prostate cancer .
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1
1 Cited Publications
Cat. No.: HY-P1329A
Target:  

Opioid Receptor

Domaines de recherche:  

Neurological Disease

CTOP TFA is a potent and highly selective μ-opioid receptor antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity .
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Cat. No.: HY-107663A
CAS No.: 35240-69-8
Pureté:  98.01%
Synonyms: Pro-Leu-Gly-NH2 TFA; Melanostatin TFA
Target:  

Dopamine Receptor

Domaines de recherche:  

Neurological Disease

MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) .
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