35240-69-8
Chemical Structure
MIF-1 TFA
Synonym(s): Pro-Leu-Gly-NH2 TFA; Melanostatin TFA
- CAS No.: 35240-69-8
- Formula:C15H25F3N4O5
- Molecular Weight:398.38
IUPAC Name: (S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
InChIKey: RNHWSCDHHHUWRY-IYPAPVHQSA-N
SMILES: O=C(NCC(N)=O)[C@H](CC(C)C)NC([C@@H]1CCCN1)=O.OC(C(F)(F)F)=O
Biological Activity: MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB)[1][2][3].
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MIF-1 TFA | 99.34% | MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB). | ||||||||||||||||||||
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- [1]. Bocheva A, et, al. Antiopioid properties of the TYR-MIF-1 family. Methods Find Exp Clin Pharmacol. 2004 Nov;26(9):673-7. [Content Brief]
- [2]. Valentijn JA, et, al. Melanostatin (NPY) inhibited electrical activity in frog melanotrophs through modulation of K+, Na+ and Ca2+ currents. J Physiol. 1994 Mar 1;475(2):185-95. [Content Brief]
- [3]. Saleh MI, et, al. MIF-1 attenuates spiroperidol alteration of striatal dopamine D2 receptor ontogeny. Peptides. 1989 Jan-Feb;10(1):35-9. [Content Brief]
Keywords
