1 Result for "

SC4642

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "SC4642" in MCE Product Catalog:

Norethynodrel
Norethynodrel
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Cat. No.: HY-B1341
CAS No.: 68-23-5
Synonyms: Enidrel; SC-4642; NSC 15432
Category:  

Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:  

Endogenous Metabolite Progesterone Receptor

Norethynodrel (Enidrel; SC-4642) is an orally active progestogen analog that reduces estrogen-like effects and enhances progestogen-like responses in endometrial stromal cells. Norethynodrel also promotes cell maturation and predecidual cell formation by inducing organelle hyperplasia and glycogen accumulation. Norethynodrel competitively inhibits drug-metabolizing enzymes in rat liver microsomes, thereby prolonging Pentobarbital sleep time, while exhibiting multiple effects including reduced body weight gain, attenuated heart rate elevation and ovulation inhibition. In mouse models, Norethynodrel significantly increases the incidence of mammary adenocarcinoma, cervical cancer and pituitary tumors. Norethynodrel can be used for mechanism research on related diseases such as mammary adenocarcinoma, cervical cancer, ovarian tubular adenoma and pituitary adenoma .
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