4 Results for "

Sclerotium rolfsii

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "Sclerotium rolfsii" in MCE Product Catalog:

Thifluzamide
Thifluzamide
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Cat. No.: HY-B2004
CAS No.: 130000-40-7
Target:  

Environmental Pollutants Fungal Mitochondrial Metabolism

Research Areas:  

Infection

Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants .
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3-Methylcarbazole
3-Methylcarbazole
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Cat. No.: HY-W047478
CAS No.: 4630-20-0
Synonyms: NSC 10154
Category:  

Alkaloids other families Plants Disease Research Fields Cancer Indole Alkaloids

Target:  

Fungal Interleukin Related

3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC50 of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases .
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(E)-2-Octenal
(E)-2-Octenal
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Cat. No.: HY-W134163
CAS No.: 2548-87-0
Synonyms: trans-2-Octenal
Category:  

Natural Products Vitis vinifera cv. Zalema Plants Vitaceae

Target:  

Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Phosphatase Pyruvate Kinase

(E)-2-Octenal is an Antifungal agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot .
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Sotolone
Sotolone
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Cat. No.: HY-W021008
CAS No.: 28664-35-9
Synonyms: Dimethylhydroxyfuranone
Category:  

Natural Products Grona styracifolia (Osbeck) H. Ohashi & K. Ohashi Plants Fabaceae

Target:  

Fungal

Sotolone (Dimethylhydroxyfuranone) is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro .
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