158 Results for "

TNFRSF17/BCMA/CD269&CD3E

" in MedChemExpress (MCE) Product Catalog:
Products (158)

158 Results for "TNFRSF17/BCMA/CD269&CD3E" in MCE Product Catalog:

8
8 Publications Verification
Cat. No.: HY-15578
CAS No.: 863971-19-1
Pureté:  99.96%
Synonyms: Maleimidocaproyl monomethylauristatin F
Domaines de recherche:  

Cancer

McMMAF (Maleimidocaproyl monomethylauristatin F) is a drug-linker conjugate for ADCs, formed by coupling the potent microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with a maleimidocaproyl (mc) linker. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth [3] .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P9963
CAS No.: 853426-35-4
Synonyms: bscCD19xCD3; AMG-103; MEDI-538; MT-103; BLINCYTO

Target:  

CD19

Domaines de recherche:  

Cancer

Blinatumomab (Anatumomab) is a bispecific monoclonal antibody with two binding sites, one for CD3E on T cells and one for CD19 on B cells. Blinatumomab can be used in research for acute lymphoblastic leukemia [3] .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P9980
CAS No.: 2061894-48-0
Synonyms: GSK2857914

Domaines de recherche:  

Cancer

Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P80598
Synonyms: CD3E; T3E; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD3E

Host:  

Rabbit

Application:  

WB, IHC-P, IP

Reactivity:  

Human

loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P78070
Pureté:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF17; TNFRSF13A; Prev. BCMA; Tumor Necrosis Factor Receptor Superfamily, Member 17; BCM; B Cell Maturation Antigen; Tumor Necrosis Factor Receptor Superfamily Member 17; B-Cell Maturation Factor; B-Cell Maturation Protein; CD269 Antigen; TNF Receptor
Species:  
Human
Source:  
HEK293
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P3239
CAS No.: 2050232-20-5
Synonyms: GSK2857916; Belantamab mafodotin-blm
Domaines de recherche:  

Cancer

Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. The antibody portion is Belantamab (HY-P9980), and the drug-linker conjugate for ADC is McMMAF (HY-15578). Belantamab mafodotin has anti-myeloma activity .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P99814
CAS No.: 2250292-39-6
Synonyms: AMG-701

Target:  

CD3

Domaines de recherche:  

Inflammation/Immunology Cancer

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM) [3] .
loading...
    loading...
Cat. No.: HY-P99909
CAS No.: 2408850-14-4
Synonyms: PF-06863135; RN-613

Target:  

TNF Receptor

Domaines de recherche:  

Inflammation/Immunology

Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody . Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002).
loading...
    loading...
Cat. No.: HY-P99332
CAS No.: 219716-33-3
Synonyms: Anti-Human CD3E Recombinant Antibody; HuM291

Target:  

Apoptosis

Domaines de recherche:  

Inflammation/Immunology Cancer

Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .
loading...
    loading...
Cat. No.: HY-P991155
CAS No.: 2988886-91-3
Synonyms: JNJ-79635322; JNJ-5322

Target:  

CD3 TNF Receptor

Domaines de recherche:  

Cancer

Ramantamig (JNJ-79635322) is a humanized monoclonal antibody targeting human CD3ε, GPRC5D, and TNFRSF17 (BCMA). Ramantamig binds to BCMA and GPRC5D on multiple myeloma cells, binds to CD3ε on T cells, forms immunological synapses, and enables T-cell-mediated cytotoxicity. Ramantamig activates T cells concomitantly with inducing myeloma cell cytotoxicity, with no nonspecific T-cell activation in the absence of target myeloma cells. Ramantamig carries mutations to reduce interaction with Fc receptors and disrupt protein A binding of monomeric and homodimerized chains. Ramantamig can be used for the research of multiple myeloma .
loading...
    loading...
Cat. No.: HY-P99868
CAS No.: 1831098-91-9
Synonyms: MGD 011

Target:  

CD19 CD3

Domaines de recherche:  

Cancer

Duvortuxizumab (MGD 011) is a chimeric humanized IG antibody targeting CD19 and CD3E .
loading...
    loading...
Cat. No.: HY-P99798
CAS No.: 2251756-52-0
Synonyms: AMG 420; BI-836909

Target:  

CD3

Domaines de recherche:  

Cancer

Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3E. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines .
loading...
    loading...
Cat. No.: HY-P99418
CAS No.: 2314491-93-3
Synonyms: AMG-160

Target:  

Inhibitory Antibodies

Domaines de recherche:  

Inflammation/Immunology

Acapatamab (AMG-160) is an anti-CD3E/FOLH1 monoclonal antibody .
loading...
    loading...
Cat. No.: HY-P9980A
Domaines de recherche:  

Cancer

Belantamab (FUT8-KO) is an anti-BCMA (TNFRSF17) monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Belantamab (FUT8-KO) can be used to synthesize antibody-active molecule conjugate (ADC), Belantamab mafodotin .
loading...
    loading...
Cat. No.: HY-P990920
CAS No.: 2851862-91-2
Synonyms: MK-6070; HPN328

Target:  

CD3

Domaines de recherche:  

Cancer

HY-P990920 is an CD3E/ALB/DLL3-targeting (scFv-heavy-lamdba)-VH-VH' type chimeric humanized antibody .
loading...
    loading...
Cat. No.: HY-P991686
CAS No.: 3038119-48-8

Target:  

TNF Receptor CD3

Domaines de recherche:  

Inflammation/Immunology Cancer

Gamgertamig is a humanized IgG4 bispecific antibody targeting TNFRSF17 & CD3E .
loading...
    loading...
Cat. No.: HY-P99912
CAS No.: 2250261-27-7
Synonyms: AMG-673

Target:  

Inhibitory Antibodies

Domaines de recherche:  

Inflammation/Immunology

Emerfetamab is an anti-CD3E/CD33 monoclonal antibody .
loading...
    loading...
Cat. No.: HY-P991034
CAS No.: 2920215-79-6

Target:  

CD3

Domaines de recherche:  

Inflammation/Immunology

HY-P991034 is an EPCAM/CD3E-targeting H-γ1_L-κ-scFvhl dimer type bispecific antibody .
loading...
    loading...
Cat. No.: HY-P990903
CAS No.: 2577961-36-3
Synonyms: YMS-5A
Target:  

CD3

Domaines de recherche:  

Inflammation/Immunology

HY-P990903 is an CD3E/CD33-targeting [H-γ1 _ L-κ-scFv heavy -κ]-dimer type bispecific antibody .
loading...
    loading...
Cat. No.: HY-P991681
CAS No.: 3051701-97-1
Synonyms: ASP-2138

Target:  

Claudin CD3

Domaines de recherche:  

Cancer

Emaretamig is a humanized IgG1κ monoclonal antibody inhibitor targeting CLDN18 and CD3E. Abdakibart can be used for cancers like gastric and pancreatic cancer research .
loading...
    loading...