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Pavurutamab

(Synonyms: AMG-701)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM).

For research use only. We do not sell to patients.

  • Purity: 99.9%
  • CAS No.: 2250292-39-6
  • Molecular Weight:105.78 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pavurutamab
  • Experimental Validation Results for Pavurutamab
  • Experimental Validation Results for Pavurutamab
  • Experimental Validation Results for Pavurutamab
  • Pavurutamab Chemical Structure
    Pavurutamab Chemical Structure
CAS No.: 2250292-39-6
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Assay Types
  • 1/16

    (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc

  • 1/16

    Immobilized Pavurutamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 1.26 ng/mL.

  • 1/16

    Immobilized Pavurutamab can bind Human BCMA Protein (ECD, His Tag). The EC50 for this effect is 0.194 ng/mL.

  • 1/16

    Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Pavurutamab (HY-P99814). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Pavurutamab Chemical Structure
    1/16
  • Pavurutamab
  • Immobilized Pavurutamab can bind Human CD3 epsilon/CD3e Protein (ECD, His Tag). The EC50 for this effect is 1.26 ng/mL.
  • Immobilized Pavurutamab can bind Human BCMA Protein (ECD, His Tag). The EC50 for this effect is 0.194 ng/mL.
  • Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Pavurutamab (HY-P99814). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control.
  • (scFv-heavy-kappa)-(scFv-heavy-lambda)-scFc