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Tie-2 Kinase

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By Targets:	Tie (18) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (2) Bcr-Abl (1) Btk (1) c-Kit (1) c-Met/HGFR (1) EGFR (1) Ephrin Receptor (1) FAK (1) FGFR (3) FLT3 (3) Insulin Receptor (3) MAP3K (1) PDGFR (2) Reference Standards (1) Src (1) TAM Receptor (1) Trk Receptor (2) Tyrosinase (1) VEGFR (13)
By Research Areas:	Cancer (18) Cardiovascular Disease (9) Inflammation/Immunology (1)

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Targets Recommended: Tie

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16135

CEP-11981 ESK981; BOL 303213X	VEGFR FGFR	Cancer
CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects .

HY-16025

EOC317 1 Publications Verification ACTB-1003	FGFR VEGFR	Cancer
EOC317 (ACTB-1003) is an oral kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and *Tie-2*.

HY-100556

Tie2 kinase inhibitor 1 1 Publications Verification	Tie	Cancer
Tie2 kinase inhibitor 1 (compound 5) is a potent, selective **Tie2 kinase inhibitor with an IC₅₀** of 250 nM . Tie2 kinase inhibitor 1 has anti-cancer activity .

HY-B0791

Altiratinib 1 Publications Verification DCC-2701	VEGFR c-Met/HGFR FLT3 Trk Receptor	Cancer
Altiratinib (DCC-2701) is a multi-targeted kinase inhibitor with IC₅₀s of 2.7, 8, 9.2, 9.3, 0.85, 4.6, 0.83 nM for MET, *TIE2, VEGFR2, FLT3, Trk1, Trk2, and Trk3* respectively.

HY-113571

Tie2 kinase inhibitor 2	Tie	Cardiovascular Disease
Tie2 kinase inhibitor 2 (compound 7) is a selective **Tie2 kinase inhibitor with an IC₅₀** value of 1 μM. Tie2 kinase inhibitor 2 inhibits endothelial cell tube formation, and can be used for Tie2-mediated angiogenic disorders research .

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-123450

S116836	Bcr-Abl Apoptosis PDGFR	Cancer
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-160708

Tie2 kinase inhibitor 3	Tie	Cancer
Tie2 kinase inhibitor 3 (compound 63) is a potent *Tie-2* kinase inhibitor with good oral activity (IC₅₀=30 nM). Tie2 kinase inhibitor 3 inhibits phosphorylation and signaling of *Tie-2* by competing with the ATP binding site of *Tie-2* kinase. This inhibition affects the stability and maturity of blood vessels, which has an impact on tumor angiogenesis. Tie2 kinase inhibitor 3 can be used to restrict tumor growth and regulate angiogenesis .

HY-156638

TIE-2/VEGFR-2 kinase-IN-5	Tie VEGFR	Cardiovascular Disease
TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent *TIE-2* and VEGFR-2 tyrosine kinase inhibitor with pIC₅₀ values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis .

HY-156635

TIE-2/VEGFR-2 kinase-IN-3	Tie VEGFR	Cardiovascular Disease
TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent *TIE-2* and VEGFR-2 tyrosine kinase receptors inhibitors with IC₅₀ values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis .

HY-156637

TIE-2/VEGFR-2 kinase-IN-4	Tie VEGFR	Cardiovascular Disease
TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent *TIE-2* and VEGFR-2 tyrosine kinase receptors inhibitors with IC₅₀ values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis .

HY-E70784

**TIE2 Y897S Recombinant Human Active Protein Kinase**	Tie	Cardiovascular Disease
TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 Y897S is the most mutation of TIE2. TIE2 Y897S Recombinant Human Active Protein Kinase is a recombinant TIE2 Y897S protein that can be used to study TIE2 Y897S-related functions .

HY-E70783

**TIE2 Y1108F Recombinant Human Active Protein Kinase**	Tie	Cardiovascular Disease
TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 Y1108F is the most mutation of TIE2. TIE2 Y1108F Recombinant Human Active Protein Kinase is a recombinant TIE2 Y1108F protein that can be used to study TIE2 Y1108F-related functions .

HY-E70782

**TIE2 R849W Recombinant Human Active Protein Kinase**	Tie	Cardiovascular Disease
TIE2 plays an important role in vascular formation and maintenance. Mutations in TIE2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. TIE2 R849W is the most common mutation implicated in an inherited form of vascular malformations. TIE2 R849W Recombinant Human Active Protein Kinase is a recombinant TIE2 R849W protein that can be used to study TIE2 R849W-related functions .

HY-13023

AMG-Tie2-1	VEGFR	Cancer
AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC₅₀ of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC₅₀ of 3 nM .

HY-112423

CE-245677	Trk Receptor Tie	Cardiovascular Disease Cancer
CE-245677 is a potent reversible inhibitor of *Tie2* and TrkA/B kinases with a cellular IC₅₀s of 4.7 and 1 nM.

HY-12572

TIE-2/VEGFR-2 kinase-IN-2	Tie VEGFR	Cancer
TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and *Tie-2* inhibitor with pIC₅₀ values of 8.61 and 8.56, respectively . TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research .

HY-112294

TIE-2/VEGFR-2 kinase-IN-1	Tie VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis .

HY-107144

LY2457546	Tyrosinase Ephrin Receptor VEGFR PDGFR FLT3 Tie	Cancer
LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, *Tie-2* and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia .

HY-100556R

Tie2 kinase inhibitor 1 (Standard)	Tie Reference Standards	Cancer
Tie2 kinase inhibitor 1 (Standard) is the analytical standard of Tie2 kinase inhibitor 1 (HY-100556). This product is intended for research and analytical applications. Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM . Tie2 kinase inhibitor 1 has anti-cancer activity .

HY-N3634

Corylifol C	EGFR TAM Receptor Tie	Cancer
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

HY-100824

PP2 Analog	Src	Cancer
PP2 Analog (compound 3) is a ATP-competitive Src family kinases inhibitor with the IC₅₀ values of 0.22, 0.15, 2.68, and 7 aganist of lck (64-509), src , kdr, and tie-2 .

HY-16135A

CEP-11981 tosylate ESK981 tosylate; BOL 303213X tosylate	VEGFR FGFR	Others Cancer
CEP-11981 (tosylate) (ESK981 (tosylate), BOL 303213X (tosylate)) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects .

HY-14243

CEP-14083	Anaplastic lymphoma kinase (ALK) Insulin Receptor VEGFR Tie	Cancer
CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC₅₀ value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma .

HY-N17788

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether	Tie	Cancer
6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of *Tie2* kinase, with an IC₅₀ value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea .

HY-111277

CEP-14513	Anaplastic lymphoma kinase (ALK) Insulin Receptor VEGFR Tie MAP3K Apoptosis	Cancer
CEP-14513 is an ALK inhibitor with an IC₅₀ of 4 nM. CEP-14513 also inhibits insulin receptor, VEGFR2, *TIE2* and DLK kinases, but does not inhibit MET, IKKβ, or CDK1/2/5. CEP-14513 induces cancer cell apoptosis. CEP-14513 is applicable to research related to non-small cell lung cancer, anaplastic large cell lymphoma, inflammatory myofibroblastic tumor, and diffuse large B-cell lymphoma .

Cat. No.	Product Name	Target	Research Area

HY-P5438

Srctide	Btk c-Kit FAK FLT3 Insulin Receptor	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Corylifol C	Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Source Classification	EGFR TAM Receptor Tie
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether	Structural Classification Monophenols Animals Phenols Source Classification	Tie
6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of *Tie2* kinase, with an IC₅₀ value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea .

Species:	Human (4)
Tag:	His (3) Strep (2) Avi (1) GST (1)
Source:	sf9 insect cells (3) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702705

	TIE-2 Protein, Human (Biotinylated, sf9, Avi) TEK; TEK tyrosine Kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; Tie 2; Tie2; VMCM1; hTie2; p140 TEK; soluble Tie2 variant 1; soluble Tie2 variant 2; endothelial tyrosine Kinase; tyrosine-protein Kinase receptor TEK; tunica interna endothelial cell Kinase; tyrosine-protein Kinase receptor Tie-2; tyrosine Kinase with Ig and EGF homology domains-2; VMCM; Tie-2; CD202B	Human	Sf9 insect cells
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and exerts a global control over angiogenesis and vascular stability. It regulates endothelial cell survival, proliferation, migration, adhesion, and actin cytoskeletal reorganization. TIE-2 Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived TIE-2, expressed by Sf9 insect cells, with Avi labeled tag.

HY-P705889

	TIE-2 Protein, Human (Active, L914F, sf9, His-GST) TEK; TEK tyrosine Kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; Tie 2; Tie2; VMCM1; hTie2; p140 TEK; soluble Tie2 variant 1; soluble Tie2 variant 2; endothelial tyrosine Kinase; tyrosine-protein Kinase receptor TEK; tunica interna endothelial cell Kinase; tyrosine-protein Kinase receptor Tie-2; tyrosine Kinase with Ig and EGF homology domains-2; VMCM; Tie-2; CD202B	Human	sf9 insect cells

HY-P705890

	TIE-2 Protein, Human (Active, R849W, sf9, His-Strep) TEK; TEK tyrosine Kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; Tie 2; Tie2; VMCM1; hTie2; p140 TEK; soluble Tie2 variant 1; soluble Tie2 variant 2; endothelial tyrosine Kinase; tyrosine-protein Kinase receptor TEK; tunica interna endothelial cell Kinase; tyrosine-protein Kinase receptor Tie-2; tyrosine Kinase with Ig and EGF homology domains-2; VMCM; Tie-2; CD202B	Human	sf9 insect cells

HY-P705891

	TIE-2 Protein, Human (Active, Y897S, sf9, His-Strep) TEK; TEK tyrosine Kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; Tie 2; Tie2; VMCM1; hTie2; p140 TEK; soluble Tie2 variant 1; soluble Tie2 variant 2; endothelial tyrosine Kinase; tyrosine-protein Kinase receptor TEK; tunica interna endothelial cell Kinase; tyrosine-protein Kinase receptor Tie-2; tyrosine Kinase with Ig and EGF homology domains-2; VMCM; Tie-2; CD202B	Human	sf9 insect cells

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HY-P87105

	TIE2 Antibody (YA6798) Angiopoietin 1 receptor antibody; Angiopoietin-1 receptor antibody; CD202b antibody; CD202b antigen antibody; Endothelial tyrosine Kinase antibody; Endothelium specific receptor tyrosine Kinase 2 antibody; hTie 2 antibody; hTie2 antibody; Hyk antibody; p140 TEK antibody; Angiopoietin 1 receptor antibody; Angiopoietin-1 receptor antibody; CD202b antibody; CD202b antigen antibody; Endothelial tyrosine Kinase antibody; Endothelium specific receptor tyrosine Kinase 2 antibody; hTie 2 antibody; hTie2 antibody; Hyk antibody; p140 TEK antibody; Soluble Tie2 variant 1 antibody; Soluble Tie2 variant 2 antibody; Tek antibody; tek tyrosine Kinase antibody; TEK tyrosine Kinase endothelial antibody; tek tyrosine Kinase, endothelial antibody; Tie 2 antibody; Tie2 antibody; Tie2_HUMAN antibody; Tunica interna endothelial cell Kinase antibody; Tyrosine Kinase with Ig and EGF homology domains 2 antibody; Tyrosine Kinase with Ig and EGF homology domains-2 antibody; Tyrosine protein Kinase receptor TEK antibody; Tyrosine protein Kinase receptor Tie 2 antibody; Tyrosine-protein Kinase receptor TEK antibody; Tyrosine-protein Kinase receptor Tie-2 antibody; Venous malformations multiple cutaneous and mucosal antibody; VMCM 1 antibody; VMCM antibody; VMCM1 antibody;	WB, FC	Human
	TIE2 Antibody (YA6798) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TIE2.

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Tie-2 Kinase

Inhibitors & Agonists

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