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Tie2 kinase inhibitor 1 

Cat. No.: HY-100556 Purity: >98.0%
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Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM. Tie2 kinase inhibitor 1 has anti-cancer activity.

For research use only. We do not sell to patients.

Tie2 kinase inhibitor 1 Chemical Structure

Tie2 kinase inhibitor 1 Chemical Structure

CAS No. : 948557-43-5

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Description

Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].

IC50 & Target

IC50: 250 nM (Tie2)[1]

In Vitro

Tie2 kinase inhibitor 1 (compound 5) has an IC50 of 50 μM for p38 and has moderate to excellent cellular activities (cell IC50=232 nM)[1].
Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)[2].

In Vivo

Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks[1].

Animal Model: Athymic nude mice (6- to 8-week-old females)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneally; twice a week for 6 weeks
Result: Resulted in statistically significant reductions in tumor volume.
Molecular Weight

439.53

Formula

C₂₆H₂₁N₃O₂S

CAS No.

948557-43-5

SMILES

O=S(C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C5C=C(OC)C=CC5=C4)N2)C=C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

Tie2 kinase inhibitor 1OthersTie2kinaseanti-cancertunicainternalendothelialtumorInhibitorinhibitorinhibit

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Tie2 kinase inhibitor 1
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HY-100556
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