Pyridinylimidazole inhibitors of Tie2 kinase

  • Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. doi: 10.1016/j.bmcl.2007.06.068.
Marcus Semones  1 ,  Yanhong Feng ,  Neil Johnson ,  Jerry L Adams ,  Jim Winkler ,  Michael Hansbury
Affiliations
PMID: 17618114 DOI: 10.1016/j.bmcl.2007.06.068
Abstract

This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.

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