1. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  2. Trk Receptor
  3. CE-245677

CE-245677 

Cat. No.: HY-112423
Handling Instructions

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

For research use only. We do not sell to patients.

CE-245677 Chemical Structure

CE-245677 Chemical Structure

CAS No. : 717899-97-3

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Description

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

In Vitro

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].

In Vivo

CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].

Molecular Weight

513.38

Formula

C₂₄H₂₂Cl₂N₆O₃

CAS No.

717899-97-3

SMILES

O=C(NC1=CC=C(Cl)C=C1Cl)NC2=CC(C(C3=CN(C(C)C)C4=NC=NC(N)=C43)=O)=CC=C2OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CE-245677
Cat. No.:
HY-112423
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