1. Protein Tyrosine Kinase/RTK
  2. Trk Receptor

CE-245677 

Cat. No.: HY-112423
Handling Instructions

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

For research use only. We do not sell to patients.

CE-245677 Chemical Structure

CE-245677 Chemical Structure

CAS No. : 717899-97-3

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.

In Vitro

CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, and displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases, such as KDR, PDGFR, FGFR[1].

In Vivo

CE-245677 shows good oral absorption in in vivo rat PK studies (F=80%)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9479 mL 9.7394 mL 19.4787 mL
5 mM 0.3896 mL 1.9479 mL 3.8957 mL
10 mM 0.1948 mL 0.9739 mL 1.9479 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

513.38

Formula

C₂₄H₂₂Cl₂N₆O₃

CAS No.

717899-97-3

SMILES

O=C(NC1=CC=C(Cl)C=C1Cl)NC2=CC(C(C3=CN(C(C)C)C4=NC=NC(N)=C43)=O)=CC=C2OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CE-245677
Cat. No.:
HY-112423
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CE-245677

Cat. No.: HY-112423