CE-245677 mesylate
CE-245677 mesylate is a selective, reversible TrkA/B and Tie2 inhibitor. CE-245677 mesylate is effective in multiple pain models and inhibits tumor growth and the proliferation of Plasmodium falciparum during the erythrocytic stage.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 941588-94-9
- 分子式: C25H26Cl2N6O6S
- 分子量:609.48
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
Parasite アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
|
TrkA |
TrkB |
Tie2 |
Plasmodium |
体外実験
CE-245677 mesylate inhibits Tie2 with a IC50 of 4.7 nM and TrkA/B with a IC50 of 1 nM, while showing ≥100-fold selectivity over KDR, PDGFR, FGFR, and gene family panels[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 941588-94-9
-
分子量 609.48
-
分子式 C25H26Cl2N6O6S
-
SMILES
O=C(NC1=CC(C(C2=CN(C(C)C)C3=C2C(N)=NC=N3)=O)=CC=C1OC)NC4=CC=C(C=C4Cl)Cl.O=S(O)(C)=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Bagal SK, et al. Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain. Journal of medicinal chemistry. 2018 Aug 09;61(15):6779-6800. [Content Brief]
[2]. Yamada T, et al. Discovery and hit to lead optimization of macrocyclic peptides as novel tropomyosin receptor kinase A antagonists. Journal of Medicinal Chemistry. 2024 Jul 1;67(13):11197-208. [Content Brief]
[7]. Skerratt SE, et al. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. Journal of medicinal chemistry. 2016 Nov 23;59(22):10084-10099. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)