AMG-Tie2-1
Based on 1 Customer Validation
AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM.
For research use only. We do not sell to patients.
- Purity: 99.5%
- CAS No.: 870223-96-4
- Formula: C25H20F3N5O2
- Molecular Weight:479.45
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All VEGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RD | IC50 |
10.5 μM
Compound: 7, AMG-Tie-2-1, NCGC00263199
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Antiproliferative activity against human RD cells after 48 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human RD cells after 48 hrs by CellTiter-Glo luminescent assay
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[PMID: 23787099] |
| SJRH30 | IC50 |
6 μM
Compound: 7, AMG-Tie-2-1, NCGC00263199
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Antiproliferative activity against human Rh30 cells after 48 hrs by CellTiter-Glo luminescent assay
Antiproliferative activity against human Rh30 cells after 48 hrs by CellTiter-Glo luminescent assay
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[PMID: 23787099] |
AMG-Tie2-1 (compound 15) inhibits Tie-2 phosphorylation in EA.hy926 human endothelial cells (IC50=10 nM).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 870223-96-4
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Appearance Solid
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Molecular Weight 479.45
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Formula C25H20F3N5O2
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Color White to off-white
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SMILES
CNC1=NC(C2=CC=CN=C2OC3=C(C)C=CC(C(NC4=CC=CC(C(F)(F)F)=C4)=O)=C3)=CC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 175 mg/mL (365.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0857 mL | 10.4286 mL | 20.8572 mL | 52.1431 mL |
| 5 mM | 0.4171 mL | 2.0857 mL | 4.1714 mL | 10.4286 mL | |
| 10 mM | 0.2086 mL | 1.0429 mL | 2.0857 mL | 5.2143 mL | |
| 15 mM | 0.1390 mL | 0.6952 mL | 1.3905 mL | 3.4762 mL | |
| 20 mM | 0.1043 mL | 0.5214 mL | 1.0429 mL | 2.6072 mL | |
| 25 mM | 0.0834 mL | 0.4171 mL | 0.8343 mL | 2.0857 mL | |
| 30 mM | 0.0695 mL | 0.3476 mL | 0.6952 mL | 1.7381 mL | |
| 40 mM | 0.0521 mL | 0.2607 mL | 0.5214 mL | 1.3036 mL | |
| 50 mM | 0.0417 mL | 0.2086 mL | 0.4171 mL | 1.0429 mL | |
| 60 mM | 0.0348 mL | 0.1738 mL | 0.3476 mL | 0.8691 mL | |
| 80 mM | 0.0261 mL | 0.1304 mL | 0.2607 mL | 0.6518 mL | |
| 100 mM | 0.0209 mL | 0.1043 mL | 0.2086 mL | 0.5214 mL |
AMG-Tie2-1 Related Classifications
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