2. Protein Tyrosine Kinase/RTK
  3. VEGFR FGFR
  4. CEP-11981

CEP-11981  (Synonyms: ESK981; BOL 303213X)

Cat. No.: HY-16135 Purity: 99.18%
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CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects.

For research use only. We do not sell to patients.

CEP-11981 Chemical Structure

CEP-11981 Chemical Structure

CAS No. : 856691-93-5

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Based on 1 publication(s) in Google Scholar

Other Forms of CEP-11981:

CEP-11981 Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All FGFR Isoform Specific Products:

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FGFR FGFR1 FGFR2 FGFR3 FGFR4 FGF21

  • Biological Activity

  • Purity & Documentation

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Description

CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1].

In Vitro

CEP-11981(1μM, 72 h) can significantly inhibit the growth of RT4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CEP-11981 Related Antibodies
In Vivo

CEP-11981(2.5 mg/kg, 5 mg/kg or 10 mg/kg, oral gavage, daily, five days a week for two weeks) significantly arrested the growth of UC xenografts compared to control with no change in weight in murine xenograft model of RT4 human UC tumor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

477.56

Formula

C28H27N7O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)CN(C1=C2C3=C(C(NC3)=O)C4=C1CCC5=NN(C)C=C54)C(C2=C6)=CC=C6NC7=NC=CC=N7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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CEP-11981 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CEP-11981856691-93-5ESK981 BOL 303213XCEP11981CEP 11981ESK 981ESK-981VEGFRFGFRVascular endothelial growth factor receptorFibroblast growth factor receptortyrosine kinaseTIE2VEGFR1-3FGFR1anti-tumoranti-angiogenicInhibitorinhibitorinhibit

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