501693-48-7
501693-48-7
Chemical Structure
TIE-2/VEGFR-2 kinase-IN-2
- CAS No.: 501693-48-7
- Formula:C20H13F4N5O2
- Molecular Weight:431.34
IUPAC Name: 1-(4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
InChIKey: KNDPXYAMINMLED-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC(C=C2)=CC=C2C3=COC4=C3C(N)=NC=N4
Biological Activity: TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TIE-2/VEGFR-2 kinase-IN-2 | 99.81% | TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.79
HY-156638TIE-2/VEGFR-2 kinase-IN-5 -
Similarity Score 0.70
HY-125741GW768505A free base -
Similarity Score 0.66
HY-101963AD80 -
Similarity Score 0.58
HY-50751Linifanib -
Similarity Score 0.58
HY-18507AD57 -
Similarity Score 0.58
HY-130643PERK-IN-3 -
Similarity Score 0.58
HY-18507AAD57 hydrochloride -
Similarity Score 0.57
HY-167869A-849529 -
Similarity Score 0.57
HY-U00177GDP366 -
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