501693-48-7

TIE-2/VEGFR-2 kinase-IN-2 Chemical Structure
501693-48-7

Chemical Structure

TIE-2/VEGFR-2 kinase-IN-2

  • CAS No.: 501693-48-7
  • Formula:C20H13F4N5O2
  • Molecular Weight:431.34

IUPAC Name: 1-(4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

InChIKey: KNDPXYAMINMLED-UHFFFAOYSA-N

SMILES: O=C(NC1=CC(C(F)(F)F)=CC=C1F)NC(C=C2)=CC=C2C3=COC4=C3C(N)=NC=N4

Biological Activity: TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].

Cat. No. 상품명 Purity 제품 설명 Pricing
HY-12572
TIE-2/VEGFR-2 kinase-IN-2 99.81% TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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References