1. Apoptosis
  2. Survivin
  3. GDP366

GDP366 

Cat. No.: HY-U00177 Purity: 99.73%
Handling Instructions

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.

For research use only. We do not sell to patients.

GDP366 Chemical Structure

GDP366 Chemical Structure

CAS No. : 501698-03-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.

IC50 & Target

Survivin[1]
Op18[1]

In Vitro

GDP366 potently and selectively inhibits the expression of both survivin and Op18. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis. GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 increases chromosomal instability, and induces cellular senescence by inhibiting telomerase activity[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (166.47 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6635 mL 13.3174 mL 26.6347 mL
5 mM 0.5327 mL 2.6635 mL 5.3269 mL
10 mM 0.2663 mL 1.3317 mL 2.6635 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.54 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

375.45

Formula

C₂₀H₁₇N₅OS

CAS No.

501698-03-9

SMILES

O=C(NC1=CC=CC(C)=C1)NC2=CC=C(C3=CSC4=NC=NC(N)=C43)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GDP366
Cat. No.:
HY-U00177
Quantity:

GDP366

Cat. No.: HY-U00177