3 Results for "

WI-38 human embryonic lung fibroblast cells

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "WI-38 human embryonic lung fibroblast cells" in MCE Product Catalog:

1
Lixumistat
Lixumistat
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1 Cited Publications
Cat. No.: HY-136093B
CAS No.: 1422365-93-2
Synonyms: IM156 free base; HL156A free base; HL271 free base
Target:  

Mitochondrial Metabolism AMPK

Research Areas:  

Neurological Disease Inflammation/Immunology

Lixumistat (IM156 free base) is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis .
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Rotundic acid
Rotundic acid
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Cat. No.: HY-N2217
CAS No.: 20137-37-5
Category:  

Cardiovascular Disease Triterpenes Plants Aquifoliaceae other families Microorganisms Terpenoids Parameria laevigata (Juss.) Moldenke Disease Research Fields Inflammation/Immunology Cancer

Target:  

Akt mTOR p38 MAPK Apoptosis Phosphatase Interleukin Related NF-κB PI3K Keap1-Nrf2 Heme Oxygenase (HO) Toll-like Receptor (TLR) Reactive Oxygen Species (ROS)

Rotundic acid is an orally effective triterpenoid with a Kd value of 51.3 µM for PTP1B. Rotundic acid downregulates the AKT/mTOR pro-survival pathway and modulates the MAPK pathway. Rotundic acid induces cell cycle S-phase arrest, DNA damage and apoptosis; it inhibits migration, invasion, angiogenesis and proliferation of cancer cells. Rotundic acid improves leptin sensitivity, regulates gut microbiota and reduces cellular senescence. Rotundic acid can be used in research related to hepatocellular carcinoma, obesity, aging, acute lung injury and type 2 diabetes .
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RKN5755
RKN5755
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Cat. No.: HY-187689
CAS No.: 1005056-10-9
Target:  

Arrestin

Research Areas:  

Cancer

RKN5755 is a β-arrestin1 inhibitor and a selective inhibitor of activated fibroblasts. RKN5755 binds to β-arrestin1 and interferes with the cofilin signaling pathway mediated by this protein to block its function. RKN5755 not only inhibits the enhanced migratory effect of fibroblasts co-cultured with cancer cells, but also prevents the inhibitory effect of EP3 agonists on the EP2 receptor-induced elevation of tetrodotoxin-resistant sodium currents in mouse dorsal root ganglion neurons. RKN5755 is widely used in research on related diseases such as cancer metastasis and pain .
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