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Results for "

active metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (352) Endogenous Metabolite (141) 11β-HSD (1) 15-PGDH (1) 5-HT Receptor (25) ADC Linker (1) ADC Payload (3) Adenosine Receptor (2) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (25) Akt (10) Aldehyde Dehydrogenase (ALDH) (5) Amino Acid Derivatives (1) Aminopeptidase (2) Aminotransferases (Transaminases) (1) Amyloid-β (8) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (18) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (21) Antibiotic (20) Antifolate (11) Apoptosis (73) Aryl Hydrocarbon Receptor (2) Autophagy (33) Bacterial (50) Bcl-2 Family (6) Beta-secretase (1) Biochemical Assay Reagents (1) Btk (4) c-Fms (1) c-Kit (2) Calcium Channel (6) CaMK (2) Carbonic Anhydrase (4) Carboxylesterase (CES) (1) Caspase (7) CaSR (1) Cathepsin (1) CD38 (1) CDK (5) CHIKV (10) Cholinesterase (ChE) (6) CMV (3) Collagen (1) COMT (5) COX (34) Cytochrome P450 (28) Dihydrofolate reductase (DHFR) (2) Dihydroorotate Dehydrogenase (3) Dipeptidyl Peptidase (2) DNA Alkylator/Crosslinker (7) DNA/RNA Synthesis (46) Dopamine Receptor (22) Drug Derivative (10) Drug Intermediate (9) Drug Isomer (7) Drug-Linker Conjugates for ADC (9) EBV (3) EGFR (12) Endothelin Receptor (5) Enterovirus (5) Environmental Pollutants (10) Ephrin Receptor (1) ERK (7) Estrogen Receptor/ERR (16) Eukaryotic Initiation Factor (eIF) (1) Factor Xa (1) Ferroptosis (10) FKBP (3) Flavivirus (1) Fluorescent Dye (1) Fungal (18) FXR (8) G protein-coupled Bile Acid Receptor 1 (3) GABA Receptor (3) Gap Junction Protein (3) Glucocorticoid Receptor (15) GLUT (2) Glutathione Peroxidase (8) Glutathione S-transferase (1) Glycosidase (7) GPR109A (5) HBV (5) HCV (9) HDAC (4) Heme Oxygenase (HO) (1) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (23) HIV (19) HIV Protease (5) HMG-CoA Reductase (HMGCR) (3) HSV (8) Hydroxycarboxylic Acid Receptor (HCAR) (3) IFNAR (2) IGF-1R (5) IKK (2) IMPDH (2) Influenza Virus (16) Insecticide (2) Integrin (5) Interleukin Related (16) IRE1 (3) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (158) JAK (3) JNK (5) Keap1-Nrf2 (13) Kinesin (1) Lactate Dehydrogenase (2) LDLR (1) Leukotriene Receptor (1) Lipase (3) Lipoxygenase (4) LPL Receptor (6) LXR (1) mAChR (15) MAP4K (2) MDM-2/p53 (1) MEK (3) mGluR (1) Microtubule/Tubulin (10) Mitochondrial Metabolism (1) MMP (6) Molecular Glues (1) Monoamine Oxidase (4) Monoamine Transporter (3) mTOR (3) MyD88 (2) nAChR (4) NEKs (1) Neprilysin (3) Neurokinin Receptor (1) NF-κB (19) NO Synthase (2) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (19) OAT (1) Opioid Receptor (8) Orthopoxvirus (4) Oxidative Phosphorylation (2) P-glycoprotein (5) P2Y Receptor (8) p38 MAPK (6) Parasite (43) PARP (1) PD-1/PD-L1 (2) PDGFR (3) Penicillin-binding protein (PBP) (5) Peptide-Drug Conjugates (PDCs) (2) PGE synthase (5) Phosphatase (1) Phosphodiesterase (PDE) (4) Phospholipase (3) Phytohormone (1) PI3K (4) PI4K (1) PKA (2) PKC (5) Polo-like Kinase (PLK) (1) Potassium Channel (11) PPAR (16) Progesterone Receptor (4) Prolyl Endopeptidase (PREP) (2) Prostaglandin Receptor (22) Proteasome (1) Proton Pump (4) Raf (2) Reactive Oxygen Species (ROS) (48) Reference Standards (159) RET (1) Reverse Transcriptase (3) RIP kinase (1) ROR (4) RSV (2) SARS-CoV (13) Ser/Thr Protease (4) Serotonin Transporter (12) SGLT (2) Sigma Receptor (1) SOD (3) Sodium Channel (4) STAT (2) Stearoyl-CoA Desaturase (SCD) (3) STING (1) TGF-beta/Smad (3) Thrombin (2) Thymidylate Synthase (1) TNF Receptor (4) Toll-like Receptor (TLR) (2) Topoisomerase (15) Transketolase (1) VD/VDR (16) VEGFR (3) Virus Protease (4) VSV (1) Xanthine Oxidase (4) β-glucuronidase (1) γ-secretase (2)
By Research Areas:	Cancer (273) Cardiovascular Disease (109) Endocrinology (67) Infection (162) Inflammation/Immunology (218) Metabolic Disease (176) Neurological Disease (204)
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Oligonucleotides:	Guanosine (1) Nucleotide Analogs (4) Nucleoside Analogs (2) Uridine (1) Cationic Lipids (1)

962

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

156

Natural
Products

194

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-10002

Calcitriol 65+ Cited Publications 1,25-Dihydroxyvitamin D3	Drug Metabolite VD/VDR Endogenous Metabolite	Cancer
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-B0016

Capecitabine 25+ Cited Publications	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-N0771

L-Isoleucine 5+ Cited Publications	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-A0132

N-Acetyl-D-glucosamine 2 Publications Verification N-Acetyl-2-amino-2-deoxy-D-glucose	Endogenous Metabolite Drug Derivative Drug Isomer Interleukin Related	Metabolic Disease Inflammation/Immunology Cancer
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .

HY-N6979

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-18719

Endoxifen (Z-isomer) 3 Publications Verification	Estrogen Receptor/ERR Drug Metabolite PKC Akt Apoptosis	Neurological Disease Cancer
Endoxifen Z-isomer hydrochloride, an orally active Tamoxifen (HY-13757A) metabolite, is a selective estrogen receptor modulator with 100-fold more potency than its parent agent, Tamoxifen. Endoxifen Z-isomer inhibits PKCβ1 kinase activity. Endoxifen Z-isomer attenuates PKCβ1-activated AKT ^Ser473 phosphorylation, diminishes AKT substrate phosphorylation, and induces Apoptosis. Endoxifen Z-isomer exhibits anticancer activity against hormone-resistant metastatic breast cancer .

HY-B0331A

Enalapril maleate 10+ Cited Publications MK-421 maleate	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Cancer
Enalapril (MK-421) maleate, the active metabolite of enalapril, is an angiotensin-converting enzyme (ACE) inhibitor.

HY-14798

Palifosfamide 2 Publications Verification Isophosphoramide mustard; IPM; ZIO-201	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.

HY-15284

Prasugrel 1 Publications Verification PCR 4099	P2Y Receptor	Cardiovascular Disease
Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .

HY-12772

Hydroxy Itraconazole R-63373	Fungal Drug Metabolite	Others
Hydroxy Itraconazole (R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-70002A

N-Desmethyl enzalutamide 1 Publications Verification N-Desmethyl MDV 3100	Androgen Receptor	Cancer
N-desmethyl Enzalutamide is the active metabolite of Enzalutamide.N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Proteasome	Cancer
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-79593

MRE-269 1 Publications Verification ACT-333679	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

HY-15284A

Prasugrel hydrochloride 1 Publications Verification PCR 4099 hydrochloride	P2Y Receptor	Cardiovascular Disease
Prasugrel hydrochloride (PCR 4099 hydrochloride), a thienopyridine and proagent, inhibits platelet function. Prasugrel hydrochloride is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .

HY-19764

GSK2983559 active metabolite 1 Publications Verification	RIP kinase	Cancer
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.

HY-131606B

Cidofovir diphosphate tritriethylamine	Drug Metabolite DNA/RNA Synthesis	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-N0771R

L-Isoleucine (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-111490

Desisobutyryl-ciclesonide 1 Publications Verification CIC-AP; Ciclesonide active principle	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.

HY-12767

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol 4-Hydroxyphenyl Carvedilol; 4-Hydroxycarvedilol	Drug Metabolite Cytochrome P450	Metabolic Disease
4-Hydroxyphenyl Carvedilol, a metabolite of Carvedilol, is an active metabolite of Carvedilol (HY-B0006) and is produced via CYP2D6-mediated oxidation .

HY-43533

Tarlox-TKI 2 Publications Verification	EGFR	Cancer
Tarlox-TKI, the active metabolite of Tarloxotinib, is an irreversible pan-ErbB TKI (Tarlox-TKI) .

HY-129491

O-Desmethyl Midostaurin CGP62221; O-Desmethyl PKC412	PKC	Cancer
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor with IC₅₀ ranging from 22-500 nM.

HY-129336

Abemaciclib metabolite M20 5 Publications Verification LSN3106726	CDK	Cancer
Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer .

HY-B1103

Hydroxyhexamide (±)-Hydroxyhexamid	Drug Metabolite	Cardiovascular Disease
Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.

HY-100646A

(Z)-10-Hydroxynortriptyline	Drug Metabolite	Neurological Disease
(Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-N6039

Gentianine 1 Publications Verification	Others	Metabolic Disease Inflammation/Immunology
Gentianine, an active metabolite of Swertiamarin, has anti-diabetic effect and anti-inflammatory property .

HY-100635

Diacetolol	Drug Metabolite	Cardiovascular Disease Endocrinology
Diacetolol is an active *metabolite* of the beta-adrenoceptor blocking agent Acebutolol (HY-17497) .

HY-W740010

N-Desmethyl rosuvastatin disodium hydrate	Drug Metabolite HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Metabolic Disease Cancer
N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504). N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism .

HY-135615A

Desmethyl Sibutramine hydrochloride N-Desmethylsibutramine hydrochloride	Serotonin Transporter	Neurological Disease Metabolic Disease
Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant .

HY-137941

Roxatidine	Histamine Receptor Caspase NF-κB p38 MAPK	Inflammation/Immunology
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers .

HY-G0001A

Lurasidone Metabolite 14283 hydrochloride	Drug Metabolite	Neurological Disease
Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone. Lurasidone is a FDA approved agent for the treatment of schizophrenia.

HY-G0003

Iloperidone metabolite Hydroxy Iloperidone P88; Hydroxy Iloperidone	Drug Metabolite	Neurological Disease
Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia .

HY-100085

21-Desacetyldeflazacort 21-desDFZ	Drug Metabolite	Inflammation/Immunology
21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-133813A

Apovincaminic acid hydrochloride salt	Drug Metabolite	Neurological Disease
Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action .

HY-133798

Sorafenib N-oxide	Cytochrome P450 Drug Metabolite	Cancer
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a K_i of 15 μM .

HY-131606

Cidofovir diphosphate	HSV CMV DNA/RNA Synthesis	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-G0002A

Lurasidone metabolite 14326 hydrochloride	Drug Metabolite	Neurological Disease
Lurasidone metabolite 14326 (hydrochloride) is an active metabolite of the atypical antipsychotic Lurasidone.

HY-129336S

Abemaciclib metabolite M20-d8 LSN3106726-d₈	CDK	Cancer
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor .

HY-G0025

Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine; (-)-β-HTBZ	Monoamine Transporter Drug Metabolite	Neurological Disease
Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (K_i=13.4 nM) . Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders .

HY-70002AS

N-Desmethyl enzalutamide-d6 N-Desmethyl MDV 3100-d₆	Androgen Receptor	Cancer
N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-N8743

Cyclo(Pro-Leu) A 65190; Cyclo-(leucyl-prolyl)	Endogenous Metabolite	Cancer
Cyclo(Pro-Leu) (A 65190) is an active metabolite. Cyclo(Pro-Leu) can be isolated from Streptomyces sp. BM8. Cyclo(Pro-Leu) can be used for the research of cancer .

HY-161795

SP3CHO	Drug Metabolite	Cancer
SP3CHO is an active metabolite generated by the metabolism of SP3N in cell culture by the action of amine oxidase. SP3CHO can induce polyubiquitination of specific proteins by recruiting the SCFFBXO22 E3 ligase complex. SP3CHO can be used in cancer therapy research .

HY-135601

Cinacalcet metabolite M4	Drug Metabolite	Cardiovascular Disease
Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease .

HY-116246

5(S)-HETE lactone	Drug Metabolite	Inflammation/Immunology
5(S)-HETE lactone is an arachidonic acid (AA) metabolite .

HY-100651

Desmethylnortriptyline	Drug Metabolite	Neurological Disease
Desmethylnortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527) , and is used to relieve the symptoms of depression .

HY-137532

7-Hydroxyquetiapine ICI 214227	Drug Metabolite	Neurological Disease
7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine ^{[1] ^.}

HY-133771AS

Nordoxepin-d3 hydrochloride Desmethyldoxepin-d3 hydrochloride	Drug Metabolite	Neurological Disease
Nordoxepin-d₃ (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant .

HY-157338

NHS-Ala-Ala-Asn-active metabolite	ADC Linker Kinesin	Cancer
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .

HY-W662579

N-Desmethyl clotiazepam Desmethylclotiazepam	Drug Metabolite	Metabolic Disease
N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam .

HY-B2124

10,11-Dihydrocarbamazepine	Drug Metabolite	Neurological Disease
10,11-Dihydrocarbamazepine is the active metabolite of Oxcarbazepine. 10,11-Dihydrocarbamazepine also is an intermediate. Oxcarbazepine is rapidly and almost completely converted to 10,11-Dihydrocarbamazepine with probable Anticonvulsant efficacy .

HY-100638

RPR132595A NPC	Drug Metabolite	Cancer
RPR132595A (NPC) is an active metabolite of CPT-11, which is generated by cytochrome P-450 3A4 (CYP3A4) and finally excreted through urine .

Cat. No.	상품명

HY-L084

Microbial Metabolite Library

914 compounds

Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine.

MCE provides a unique collection of 914 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

HY-L123

Human Metabolite Library

6,717 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,717 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

HY-L253

Fungal-Sourced Compound Library

88 compounds

For thousands of years, natural products have always been an important source for drug discovery. Fungi, due to their unique and diverse secondary metabolic capabilities, have become a valuable resource for natural active molecules. Since the discovery of penicillin, natural products derived from fungi have demonstrated significant application value in areas such as anti-infection, anti-tumor, immune regulation, and metabolic disease research. A large number of clinical drugs, such as antibiotics, immunosuppressants, and lipid-lowering drugs, are derived from fungal metabolites or their structurally optimized derivatives.

MCE fungal-derived compound library contains 88 structurally diverse and bioactive fungal natural products and their derivatives. It can be widely applied in various research fields such as antibacterial, anti-tumor, anti-inflammatory, immune regulation, epigenetics, and cell signaling pathways, providing high-quality tools for natural product drug development and high-throughput screening.

HY-L163

FDA-Approved Traditional Chinese Medicine Active Compound Library

308 compounds

Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability.

MCE designs a unique collection of 308 FDA/EMA/NMPA/PMDA etc-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

Cat. No.	상품명	Type

HY-138877

Phosphoglycolic acid	Biochemical Assay Reagents
Phosphoglycolic acid is a metabolite and a bacterial cytoplasmic component. Phosphoglycolic acid acts as a by-product generated during the preparation of phosphoglycolohydroxamic acid via hydrolysis of ethyl phosphoglycolate. Phosphoglycolic acid also functions as an active component of postbiotics .

HY-W011398

Linoleate sodium	Biochemical Assay Reagents
Linoleate sodium is an orally active IL8 regulator via the JNK and NF-κB pathway. Linoleate sodium can change the composition of fatty acids and the production of metabolites in cells. Linoleate sodium has anti-inflammatory, immune-regulating, and tumor cell growth-affecting activities .

HY-W357818

Glycinexylidide GX	Biochemical Assay Reagents
Glycinexylidide (GX) is the active metabolite of Lidocaine. Lidocaine is a local agent that can suppress or relieve pain, that inhibits sodium channels involving complex voltage and dependence. Lidocaine also reduces the growth, migration and invasion of gastric cancer cells. Glycinexylidide has research potential for use in anesthesia, cancer, and cardiovascular disease .

HY-W014841

Sodium hippurate, 98%

1 Publications Verification

N-Benzoylglycine sodium, 98%

Biochemical Assay Reagents

Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research . .

HY-137697

ddCTP

Biochemical Assay Reagents

ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .

HY-128036

ddATP 2',3'-Dideoxyadenosine 5'-triphosphate	Biochemical Assay Reagents
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP can be used for Sanger method for DNA sequencing and research of virus infection .

Cat. No.	상품명	Target	Research Area

HY-13634B

TLK117 1 Publications Verification TER117	Glutathione S-transferase	Inflammation/Immunology Cancer
TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a K_i of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a K_i of 0.56 μM.

HY-105023

Cyclosporin G	Peptides	Inflammation/Immunology
Cyclosporin G is an active metabolite that can be produced from Tolypocladium inflatum. Cyclosporin G has immunosuppressive activity. Cyclosporin G inhibits proliferation of A431 cells .

HY-P10759

DTS-201 sodium	Peptide-Drug Conjugates (PDCs) Aminopeptidase	Cancer
DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer .

HY-P2124R

Cyclo(L-Trp-L-Trp) (Standard)	Reference Standards Antibiotic Bacterial	Infection
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-P10916

Micafungin metabolite M1	Drug Metabolite Fungal	Infection
Micafungin metabolite M1 is an active metabolite of Micafungin (HY-17579), which is metabolized by arylsulfatase and exhibits antifungal activity. Micafungin metabolite M1 can be used for research on deep fungal infections caused by Candida and Aspergillus species .

Cat. No.	상품명	Target	Research Area	Image

HY-P99469

Bentracimab PB 2452; MEDI 2452	Inhibitory Antibodies	Metabolic Disease
Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor (HY-1006) and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-13704

SN-38 Maximum Cited Publications 70 Publications Verification 7-Ethyl-10-hydroxycamptothecin	Alkaloids Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Quinoline Alkaloids Plants Disease Research Fields Source Classification Cancer	Drug Metabolite Topoisomerase ADC Payload Autophagy
SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC₅₀s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254) .

HY-10002

Calcitriol 65+ Cited Publications 1,25-Dihydroxyvitamin D3	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite VD/VDR Endogenous Metabolite
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-N0771

L-Isoleucine 5+ Cited Publications	Classification of Application Fields Endocrine diseases Amino acids Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms other families Disease markers Other Diseases Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-A0132

N-Acetyl-D-glucosamine 2 Publications Verification N-Acetyl-2-amino-2-deoxy-D-glucose	Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Drug Derivative Drug Isomer Interleukin Related
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .

HY-N6979

Crustecdysone 10+ Cited Publications 20-Hydroxyecdysone	Cardiovascular Disease other families Animals Classification of Application Fields Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Disease Research Fields Steroids Source Classification	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-17042

Cetirizine 3 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Histamine Receptor
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-125850

Berberrubine chloride 2 Publications Verification	Alkaloids Phellodendron amurense Rupr. Monophenols Classification of Application Fields Rutaceae Phenols Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite HIV Interleukin Related
Berberrubine chloride is an orally active metabolite of berberine. Berberrubine chloride alleviates mucosal lesions and inflammation in mouse colitis models. Berberrubine chloride has anti-inflammatory, anti-tumor, and antiviral activities .

HY-A0019

Paliperidone 3 Publications Verification 9-Hydroxyrisperidone	Natural Products Endogenous metabolite Source Classification	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-N6735

Apicidin 5 Publications Verification OSI 2040	Infection Microorganisms Classification of Application Fields Antibiotics Anti-parasitic Disease Research Anticancer Disease Research Fields Other Antibiotics Source Classification	HDAC Parasite
Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research .

HY-118620

Nortriptyline 3 Publications Verification Desmethylamitriptyline; Desitriptilina	Alkaloids Neurological Disease Classification of Application Fields Pterocarpus santalinus L. f. Other Alkaloids Labiatae Plants Disease Research Fields Cancer Source Classification	Autophagy Drug Metabolite Apoptosis
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline is a potent autophagy inhibitor and has anticancer effects . N

HY-N0227

7-epi-Taxol 4 Publications Verification 7-epi-Paclitaxel	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	Microtubule/Tubulin
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-14925

Lapaquistat 2 Publications Verification T-91485	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Metabolite
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy .

HY-A0115

Ramiprilat HOE 498 diacid; Ramipril diacid	Cardiovascular Disease Structural Classification Alkaloids Pyrrole Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a K_i value of 7 pM. Ramiprilat has acute antlhypertensive effect. Ramiprilat can be used for high blood pressure and heart failure research .

HY-111278

Pyocyanin 2 Publications Verification Pyocyanine; Sanazin; Sanasin	Structural Classification Natural Products Microorganisms Source Classification	Reactive Oxygen Species (ROS) Bacterial Drug Metabolite Endogenous Metabolite
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

HY-W004049

3-Hydroxybenzoic acid	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR)
3-Hydroxybenzoic acid is an orally active endogenous metabolite. 3-Hydroxybenzoic acid is an agonist for GPR81 and GPR109A. 3-Hydroxybenzoic acid acts as stress response desensitizers. 3-Hydroxybenzoic acid can be used for anti-inflammatory and analgesic study .

HY-W012997

Tetrahydro-2H-pyran-2-one δ-valerolactone	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Tetrahydro-2H-pyran-2-one (δ-valerolactone) is an endogenous metabolite with antioxidant capacity. Tetrahydro-2H-pyran-2-one is the small active molecule and can be used as drug intermediate .

HY-N1548

Prunasin 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Rosaceae Plants Disease Research Fields Amygdalus persica L. Source Classification Cancer	DNA/RNA Synthesis
Prunasin is an orally active cyanogenic glucoside and the main metabolite of Amygdalin (HY-N0190). Prunasin can specifically inhibit rat DNA polymerase β (IC₅₀: 98 μM). Prunasin has anti-inflammatory and anti-fibrotic activities. Prunasin can be used in the research of diseases such as liver fibrosis .

HY-N10889

Sominone	Withania somnifera Solanaceae Plants Steroids Source Classification	Drug Metabolite RET
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Classification of Application Fields Disease Research Fields Cancer	Proteasome
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-79593

MRE-269 1 Publications Verification ACT-333679	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Prostaglandin Receptor
MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

HY-113161

L-Octanoylcarnitine	Structural Classification Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-19657

Oxypurinol Oxipurinol	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Drug Metabolite Endogenous Metabolite Xanthine Oxidase
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-118472

Benazeprilat CGS 14831	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite Angiotensin-converting Enzyme (ACE)
Benazeprilat is an orally active and the active metabolite of benazepril, a carboxyl-containing ACE inhibitor with antihypertensive activity. Benazepril is a well-established antihypertensive agent, both in monoresearch and in combination with other classes of drugs including thiazide diuretics and calcium channel blockers. Benazepril is a first-line research in reducing various pathologies associated with CV risk and secondary end-organ damage .

HY-N0179

Ecdysone 1 Publications Verification α-Ecdysone	Animals Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Apoptosis
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-N6807

Elemicin 1 Publications Verification	Infection Asarum sieboldii Miq. Classification of Application Fields Simple Phenylpropanols Phenylpropanoids Plants Disease Research Fields Aristolochiaceae Source Classification	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N0771R

L-Isoleucine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Disease markers Endocrine diseases Amino acids Nervous System Disorder Plants Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-107494A

all-trans-4-Oxoretinoic acid 1 Publications Verification all-trans 4-Keto Retinoic Acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-101417

Diethyl phosphate Diethyl phosphoric acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Interleukin Related
Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats .

HY-N0929

Hexahydrocurcumin	Classification of Application Fields Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae Cancer	COX Reactive Oxygen Species (ROS)
Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .

HY-128744

Phosphonoacetic acid 2 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Orthopoxvirus HSV DNA/RNA Synthesis
Phosphonoacetic acid is an endogenous metabolite and antiviral agent. Phosphonoacetic acid is active against orthopoxviruses and herpes viruses. Phosphonoacetic acid can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, and affect the synthesis of late viral proteins .

HY-126996

Triiodothyronine sulfate	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone, which binds to β1 thyroid hormone receptor (TRβ1), and activates its activity .

HY-N0894

Octahydrocurcumin 1 Publications Verification Hexahydrobisdemethoxycurcumin	Structural Classification Classification of Application Fields Other Diseases Phenols Polyphenols Plants Curcuma longa Disease Research Fields Source Classification Zingiberaceae	Apoptosis MAP4K NF-κB COX
Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively .

HY-N6786

Ochratoxin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Coumarins Phenols Phenylpropanoids Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos .

HY-128447

Allyl methyl sulfide 1 Publications Verification	Infection Natural Products Liliaceae Classification of Application Fields Plants Endogenous metabolite Disease Research Fields A．Sativam L. var．Viviparum Regel Source Classification	Endogenous Metabolite SOD NF-κB GLUT
Allyl methyl sulfide is an orally active organic sulfide. Allyl methyl sulfide is one of the main active ingredients in garlic volatile metabolites. Allyl methyl sulfide can be extracted from garlic. Allyl methyl sulfide enhances SOD activity, inhibits NF-κB signaling pathway, and upregulates pancreatic GLUT2 expression. Allyl methyl sulfide has significant antioxidant, anti-inflammatory and hypoglycemic activities. Allyl methyl sulfide can be used in the research of diabetes and its complications .

HY-113352

7-Methylguanine	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite PARP
7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a K_i value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions .

HY-B1746

Pyridoxamine 5′-phosphate	Alkaloids Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of Pyridoxal 5'-?phosphate monohydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-30216

(R)-Leucic acid D-α-Hydroxyisocaproic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Amino Acid Derivatives Endogenous Metabolite
(R)-Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics .

HY-W354498

L-Octanoylcarnitine hydrochloride	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
L-Octanoylcarnitine hydrochloride is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine hydrochloride can be used for the research of breast cancer .

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker in diabetic kidney disease .

HY-B0652

Etonogestrel 3-Oxodesogestrel; 3-keto-Desogestrel	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Drug Metabolite Estrogen Receptor/ERR Progesterone Receptor Endogenous Metabolite FKBP
Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .

HY-N1867

trans-Cinnamyl alcohol	Natural Products Rosaceae Plants Source Classification	PPAR
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. Cinnamyl Alcohol is an active component from chestnut flower, inhibits increased PPARγ expression, with anti-obesity activity. trans-Cinnamyl alcohol, belongs to the class of organic compounds known as cinnamyl alcohols, is a primary metabolite .

HY-N6039

Gentianine 1 Publications Verification	Gentiana macrophylla Pall. Iridoids Classification of Application Fields Terpenoids Gentianaceae Plants Disease Research Fields Inflammation/Immunology Source Classification	Others
Gentianine, an active metabolite of Swertiamarin, has anti-diabetic effect and anti-inflammatory property .

HY-135556

Norfluoxetine	Natural Products Animals Endogenous metabolite Source Classification	Drug Metabolite
Norfluoxetine is the active metabolite of antidepressant Fluoxetine (HY-B0102). Norfluoxetine is a selective inhibitor for serotonin uptake .

HY-10002R

Calcitriol (Standard) 1,25-Dihydroxyvitamin D3 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Drug Metabolite Reference Standards VD/VDR Endogenous Metabolite
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-N13292

Actinorhodin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Actinorhodin is a blue-pigmented, redox-active microbial secondary metabolite. Actinorhodin is a potent, bacteriostatic, pH-responsive antibiotic. Actinorhodin exhibits antimicrobial activity against Gram-positive bacteria .

HY-133154

Carboxyaminoimidazole ribotide 2 Publications Verification CAIR; 4-Carboxy-AIR	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Carboxyaminoimidazole ribotide (CAIR) is a metabolite of E. coli. Carboxyaminoimidazole ribotide can be used to detect distinctive features of E. coli PurE active site and synthesis fungal de novo purine .

HY-W017511

5,6-Dimethyl-1H-benzo[d]imidazole	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
5,6-Dimethyl-1H-benzo[d]imidazole is an endogenous metabolite. 5,6-Dimethyl-1H-benzo[d]imidazole is also a benzimidazole derivative and can be used in the synthesis of other active compounds .

HY-122439

Lovastatin acid Mevinolinic acid; MSD803	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	HMG-CoA Reductase (HMGCR) Drug Metabolite
Lovastatin acid (Mevinolinic acid; MSD803), an active metabolite of Lovastatin (HY-N0504), is a potent competitive HMG-CoA reductase inhibitor with a K_i of 0.6 nM. Lovastatin acid acts as a competitive inhibitor with respect to substrate HMG-CoA, interfering cholesterol synthesis. Lovastatin acid can be used for the research of hypercholesterolemia .

HY-Y1097

Monomethyl phthalate 2-(Methoxycarbonyl)benzoic acid	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Reactive Oxygen Species (ROS)
Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats .

HY-W017445

Homogentisic acid lactone	Monophenols Microorganisms Phenols Source Classification	Fungal
Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .

Cat. No.	상품명	Chemical Structure

HY-76814

Calcitriol-d6
Calcitriol-d₆ is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 and an agonist of the vitamin D receptor (VDR) .

HY-128554S

N-Desethyl amodiaquine-d5
N-Desethyl amodiaquine-d₅ is the deuterium labeled N-Desethyl amodiaquine. N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC₅₀ values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively .

HY-12772S

Hydroxy Itraconazole-d8
Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-15895S

Aprocitentan-d4
Aprocitentan-d₄ is a deuterium labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. Aprocitentan is an antihypertensive agent .

HY-B1417S

Nortriptyline-d3 hydrochloride
Nortriptyline-d₃ (hydrochloride) is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression .

HY-B0016S

Capecitabine-d11
Capecitabine-d₁₁ is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase .

HY-10002S

Calcitriol-13C3
Calcitriol- ¹³C₃ is the ¹³C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-12753S1

Debutyldronedarone-d6 hydrochloride
Debutyldronedarone-d₆ (hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent .

HY-B0559S

Nabumetone-d3
Nabumetone-d₃ is the deuterium labeled Nabumetone (HY-B0559). Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metaboliteα-Demethylnaproxen (HY-W086896). Nabumetone can inhibit cancer cells proliferation and relieve gastric ulcers .

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-17042S1

Cetirizine-d8
Cetirizine-d₈ is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .

HY-129336S

Abemaciclib metabolite M20-d8
Abemaciclib metabolite M20-d₈ is the deuterium labeled Abemaciclib metabolite M20. Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor .

HY-70002AS

N-Desmethyl enzalutamide-d6

N-desmethyl Enzalutamide-d₆ is a deuterium labeled N-desmethyl Enzalutamide. N-desmethyl Enzalutamide is an active metabolite of Enzalutamide. N-desmethyl Enzalutamide is the active metabolite of Enzalutamide. N-desmethyl Enzalutamide demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as enzalutamide .

HY-A0115S1

Ramiprilat-d5
Ramiprilat-d₅ is deuterium labeled Ramiprilat. Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a K_i value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research .

HY-10002S1

Calcitriol-d3
Calcitriol-d₃ is the deuterium labeled Calcitriol . Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist .

HY-101417S1

Diethyl phosphate-d10-1
Diethyl phosphate-d₁₀-1 is the deuterium labeled Diethyl phosphate. Diethylphosphate (Diethyl phosphoric acid) is an orally active organophosphorus pesticides metabolite. Diethylphosphate can interfere with thyroid hormone-related mechanisms and affect intestinal microbes in rats .

HY-18719ES

Endoxifen-d5
Endoxifen-d₅ is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study .

HY-130321S

Lauroyl-L-carnitine-d3 chloride
Lauroyl-L-carnitine-d₃ (chloride) is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene IL-10. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-128554S1

N-Desethyl amodiaquine-d5 dihydrochloride
N-Desethyl amodiaquine-d₅ dihydrochloride is the deuterium labeled N-Desethyl amodiaquine dihydrochloride. N-Desethyl amodiaquine dihydrochloride is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent. IC₅₀ values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively .

HY-133771AS

Nordoxepin-d3 hydrochloride
Nordoxepin-d₃ (hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride (HY-B0725), which is an orally active tricyclic antidepressant .

HY-79593S1

MRE-269-d6
MRE-269-d₆ is deuterium labeled MRE-269. MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.

HY-135391S

Ezetimibe phenoxy glucuronide-d4
Ezetimibe phenoxy glucuronide-d₄ is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity . Ezetimibe is a potent cholesterol absorption inhibitor .

HY-133794S

Dasatinib N-oxide-d8
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .

HY-100659S

Dihydrodiol-Ibrutinib-d5
Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active *metabolite* of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib .

HY-103252S2

Monomethyl fumarate-d2
Monomethyl fumarate-d₂ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-A0019S

Paliperidone-d4
Paliperidone-d₄ is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-130321S1

Lauroyl-L-carnitine-d9 chloride
Lauroyl-L-carnitine-d₉ chloride is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene IL-10. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-B0539S3

Desloratadine-d5
Desloratadine-d₅ is deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities .

HY-131606S

Cidofovir diphosphate-13C3

Cidofovir diphosphate- ¹³C₃ is the ¹³C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is the intracellular active metabolite of Cidofovir (HY-17438) and its oral prodrug Brincidofovir (HY-14532). By inhibiting viral DNA polymerase (Ki ≈ 76.3 μM), cidofovir diphosphate is widely used in studies on double-stranded DNA virus infections, including cytomegalovirus (CMV), adenovirus (AdV), and poxviruses (such as monkeypox and molluscum contagiosum virus, MCV) .

HY-B0806S1

Proguanil-d4
Proguanil-d₄ is the deuterium labeled Proguanil . Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .

HY-13609S

Deflazacort-d5
Deflazacort-d₅ is the deuterium labeled Deflazacort. Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-12785S1

Albendazole sulfoxide-d7
Albendazole sulfoxide-d₇ is the deuterium labeled Albendazole sulfoxide. Albendazole sulfoxide (Ricobendazole), the main active metabolite of Albendazole, exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes .

HY-79593S2

MRE-269-d7
MRE-269-d₇ is deuterium labeled MRE-269 (HY-79593). MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist .

HY-10003S

Alfacalcidol-d7
Alfacalcidol-d₇ is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis .

HY-12687S

Tizoxanide-d4
Tizoxanide-d₄ is the deuterium labeled Tizoxanide. Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide has anti-HIV-1 activities .

HY-130353S

Desethyl Amiodarone-d4 hydrochloride

Desethyl Amiodarone-d₄ (hydrochloride) is the deuterium labeled Desethylamiodarone hydrochloride. Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC₅₀ of 19.1 μM .

HY-19657S

Oxypurinol-13C,15N2
Oxypurinol- ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride
O-Desmethyltramadol-d6 hydrochloride is a deuterated labeled O-Desmethyltramadol hydrochloride. O-Desmethyltramadol hydrochloride is the main active metabolite of tramadol (Tramadol) and can cross the blood-brain barrier. O-Desmethyltramadol hydrochloride mainly exerts its analgesic effect by activating the µ-opioid receptor (µ-OR) .

HY-B0602S2

Desvenlafaxine-d6

Desvenlafaxine-d₆ is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC₅₀ values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter .

HY-W013378S

Carbamazepine 10,11 epoxide-d2
Carbamazepine 10,11 epoxide-d₂ is the deuterium labeled Carbamazepine 10,11 epoxide . Carbamazepine 10,11-epoxide is an orally active metabolite of Carbamazepine (HY-B0246). Carbamazepine has anticonvulsant effect. Carbamazepine can be used for the research of seizures .

HY-108251S

Methotrexate metabolite-d3
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .

HY-G0003S1

Iloperidone metabolite Hydroxy Iloperidone-d3
Iloperidone metabolite Hydroxy Iloperidone-d₃ is the deuterium labeled Iloperidone metabolite Hydroxy Iloperidone (HY-G0003). Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia .

HY-12772S3

Hydroxy Itraconazole-d6
Hydroxy Itraconazole-d₆ (R-63373-d₆) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-U00050S

(E)-10-Hydroxynortriptyline-d3
(E)-10-Hydroxynortriptyline-d₃ is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-W759719

21-Desacetyldeflazacort-d4

21-Desacetyldeflazacort-d₄ (21-desDFZ-d₄) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-100646AS

(Z)-10-Hydroxynortriptyline-d3
(Z)-10-Hydroxynortriptyline-d₃ is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-W654397

Deflazacort-d3
Deflazacort-d3 is a isotope of Deflazacort. Deflazacort is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant .

HY-119223S

Desmethylmirtazapine-d6 hydrochloride
Desmethylmirtazapine-d₆ hydrochloride (Normirtazapine-d₆ hydrochloride) is the deuterium labeled Desmethylmirtazapine (HY-119223). Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects .

HY-135400S

Glyco-obeticholic acid-d5
Glyco-obeticholic acid-d₅ is the deuterium labeled Glyco-Obeticholic acid. Glyco-obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is a farnesoid X receptor (FXR) agonist .

HY-B0806AS

Proguanil-d4 hydrochloride
Proguanil-d₄ (hydrochloride) is the deuterium labeled Proguanil hydrochloride. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor .

Cat. No.	상품명		Classification

HY-13256

Desmethyl Erlotinib hydrochloride 3 Publications Verification OSI-420; CP-373420 hydrochloride		Alkynes
Desmethyl Erlotinib hydrochloride (OSI-420) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor . Desmethyl Erlotinib (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13256A

Desmethyl Erlotinib 3 Publications Verification OSI-420 free base; CP-373420		Alkynes
Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor . Desmethyl Erlotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13256AS

Desmethyl Erlotinib-d4		Alkynes
Desmethyl Erlotinib-d₄ is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor . Desmethyl Erlotinib-d₄ is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	상품명		Classification

HY-113161

L-Octanoylcarnitine		Cationic Lipids
L-Octanoylcarnitine is a plasma metabolite and a physiologically active form of octanoylcarnitine. L-Octanoylcarnitine can be used for the research of breast cancer .

HY-137697D

ddCTP trisodium solution (100 mM)		Nucleotide Analogs
ddCTP trilithium solution (100 mM) is a chain-terminating dideoxynucleotide. ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .

HY-119499

6-Thioguanosine 6-Mercaptoguanosine		Nucleoside Analogs Guanosine
6-Thioguanosine (6-Mercaptoguanosine), an active nucleoside, is an Azathioprine metabolite. 6-Thioguanosine has immunosuppressive effects .

HY-137697

ddCTP		Nucleotide Analogs
ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .

HY-127137A

Adenylosuccinic acid tetraammonium Adenylosuccinate tetraammonium; Aspartyl adenylate tetraammonium		Nucleotide Analogs
Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is an orally active purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD) .

HY-128036

ddATP 2',3'-Dideoxyadenosine 5'-triphosphate		Nucleotide Analogs
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP can be used for Sanger method for DNA sequencing and research of virus infection .

HY-19514

Fosfluridine tidoxil		Nucleoside Analogs Uridine
Fosfluridine Tidoxil is comprised of a specific carrier molecule, coupled through a phosphate group to 5-Fluorouridine (5-FUrd), a metabolite of 5- Fluorouracil (5-FU). Fosfluridine Tidoxil is a oral active anticancer agent .

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