2 Results for "

acute splenic injury

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "acute splenic injury" in MCE Product Catalog:

2
Gypenoside XLIX
Gypenoside XLIX
0 Images
2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
Category:  

Cardiovascular Disease Triterpenes Terpenoids Cucurbitaceae Plants Disease Research Fields Gynostemma pentaphyllum (Thunb.) Makino

Target:  

PPAR Sirtuin Keap1-Nrf2 Toll-like Receptor (TLR) NF-κB Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) Apoptosis Pyroptosis Autophagy

Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a Ka value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .
loading...
    loading...
View All Sizes
MNK-IN-4
MNK-IN-4
0 Images
Cat. No.: HY-162260
CAS No.: 3032671-06-7
Target:  

MNK

Research Areas:  

Cancer

MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor for the study of sepsis-related acute splenic injury .
loading...
    loading...
View All Sizes
Assay Types