MNK-IN-4
MNK-IN-4 (compound D25) is a potent and selective MNK inhibitor for the study of sepsis-related acute splenic injury.
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- CAS No.: 3032671-06-7
- 화학식: C15H17N5
- 분자량:267.33
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
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Help & FAQs
Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.55 μM
Compound: 36; D25
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
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[PMID: 38315032] |
Chemical Information
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CAS No. 3032671-06-7
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분자량 267.33
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화학식 C15H17N5
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SMILES
C12=NC=CC(C3=CC(C4CCNCC4)=NN3)=C1C=CN2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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LPS-Induced Endotoxemia/Systemic Inflammation
Lipopolysaccharide (LPS)-induced endotoxemia is a widely used in vivo model of acute systemic inflammation in which LPS, a Gram-negative bacterial endotoxin, activates innate immune signaling primarily through TLR4, leading to rapid and transient induction of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β in circulation and tissues. This cytokine surge is commonly used as a measurable readout of systemic inflammatory activation and immune dysregulation, and is typically assessed within hours after intraperitoneal LPS administration in mouse models of endotoxemia. The model captures key features of systemic inflammatory response syndrome, including cytokine release, immune cell activation, and downstream tissue responses, and has been used to evaluate anti-inflammatory interventions such as cytokine modulation, lipid mediators, and immune cell-targeting therapies.
순도&문서
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MNK-IN-4 Related Classifications
HY-162260 Related Classifications
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