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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
allergic pulmonary inflammation
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "allergic pulmonary inflammation" in MCE Product Catalog:
2
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Nerandomilast (BI 1015550) is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD) .
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Nerandomilast (BI 1015550) dihydrate is an orally active inhibitor of PDE4B with an IC50 value of 7.2 nM. Nerandomilast (dihydrate) has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmonary disease (COPD) .
1
1 Cited Publications
Cat. No.: HY-NP159
Cat. No.: HY-P990260
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Cat. No.: HY-P10854
CAS No.: 2415370-74-8
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Cat. No.: HY-153192B
CAS No.: 1423719-31-6
Synonyms: (S)-BI 1015550
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Research Areas:
(S)-Nerandomilast ((S)-BI 1015550) is the S-isomer of Nerandomilast (HY-153192). Nerandomilast is an orally active PDE4B inhibitor with an IC50 value of 7.2 nM. Nerandomilast has good safety profile and potential applications in inflammation, allergic diseases, pulmonary fibrosis and chronic obstructive pulmonary disease (COPD).
Cat. No.: HY-150101
CAS No.: 1798578-61-6
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Research Areas:
LAS194046 is a selective pan-JAK inhibitor, with an IC50 of 5.46 nM against JAK1, 0.4 nM against JAK2, and 2.07 nM against JAK3. LAS194046 reduces the levels of IL-8 and MMP-9. LAS194046 enhances the activation of glucocorticoid response elements by Fluticasone propionate. LAS194046 inhibits T2-type allergic pulmonary inflammation, allergen-induced airway inflammation, and late-phase asthmatic responses in rats. LAS194046 can be used in research related to non-T2 severe asthma, chronic obstructive pulmonary disease, and asthma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
