1798578-61-6
Chemical Structure
LAS194046
- CAS No.: 1798578-61-6
- Formula:C34H41FN10O2
- Molecular Weight:640.75
IUPAC Name: N-((R)-3-(4-(2-(3,5-dichloro-4-((S)-3-chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)-2-hydroxypropyl)methanesulfonamide
InChIKey: IOSNQXYLFHEZTC-AREMUKBSSA-N
SMILES: FC1=C(N=C(C2=C3N(C=CC=C3)N=C2)N=C1N4CCN(CC4)CC5=CC=C(C=C5)OCCN(C)C)N[C@H]6CN(CCC6)C(CC#N)=O
Biological Activity: LAS194046 is a selective pan-JAK inhibitor, with an IC50 of 5.46 nM against JAK1, 0.4 nM against JAK2, and 2.07 nM against JAK3. LAS194046 reduces the levels of IL-8 and MMP-9. LAS194046 enhances the activation of glucocorticoid response elements by Fluticasone propionate. LAS194046 inhibits T2-type allergic pulmonary inflammation, allergen-induced airway inflammation, and late-phase asthmatic responses in rats. LAS194046 can be used in research related to non-T2 severe asthma, chronic obstructive pulmonary disease, and asthma[1][2][3].
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LAS194046 | LAS194046 is a selective pan-JAK inhibitor, with an IC50 of 5.46 nM against JAK1, 0.4 nM against JAK2, and 2.07 nM against JAK3. LAS194046 reduces the levels of IL-8 and MMP-9. LAS194046 enhances the activation of glucocorticoid response elements by Fluticasone propionate. LAS194046 inhibits T2-type allergic pulmonary inflammation, allergen-induced airway inflammation, and late-phase asthmatic responses in rats. LAS194046 can be used in research related to non-T2 severe asthma, chronic obstructive pulmonary disease, and asthma. | |||||||||||||||||||||
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References
- [1]. Milara J, et al. The pan-JAK inhibitor LAS194046 reduces neutrophil activation from severe asthma and COPD patients in vitro. Scientific reports. 2022 Mar 24;12(1):5132.
- [2]. Calbet M, et al. Novel Inhaled Pan-JAK Inhibitor, LAS194046, Reduces Allergen-Induced Airway Inflammation, Late Asthmatic Response, and pSTAT Activation in Brown Norway Rats. The Journal of pharmacology and experimental therapeutics. 2019 Aug;370(2):137-147. [Content Brief]
- [3]. Bach J, et al. Discovery of LAS194046: A Potent and Selective pan-Janus Kinase (JAK) Inhibitor with a Suitable Profile for Inhaled Administration[J]. Journal of Medicinal Chemistry, 2026, 69(16): 19601-19632.
