Search Result

Results for "

branched-chain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (10) Acetyl-CoA synthetase (2) Aminotransferases (Transaminases) (4) Antibiotic (1) Apoptosis (2) Bacterial (6) Bcl-2 Family (1) Biochemical Assay Reagents (8) CD1 (1) Drug Derivative (2) Endogenous Metabolite (30) Environmental Pollutants (4) Fluorescent Dye (3) Fungal (1) GABA Receptor (2) Herbicide (6) Histone Methyltransferase (1) HIV (2) Insulin Receptor (4) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (7) Lactate Dehydrogenase (1) Ligands for E3 Ligase (1) Lipocalin Family (1) Liposome (2) mTOR (16) PDHK (1) PKC (2) Proteasome (1) Reference Standards (9) RXFP Receptor (4) SOD (2) TNF Receptor (1) Toll-like Receptor (TLR) (1) Wnt (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (11) Infection (7) Inflammation/Immunology (7) Metabolic Disease (35) Neurological Disease (6)
Oligonucleotides:	Phospholipids (1) Cationic Lipids (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Branched Chain Amino Acid Transaminase (BCAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0486

L-Leucine 15+ Cited Publications Leucine	mTOR Endogenous Metabolite Ligands for E3 Ligase	Metabolic Disease Cancer
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0771

L-Isoleucine 5+ Cited Publications	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-114855

BT2 5+ Cited Publications	Bcl-2 Family	Metabolic Disease
BT2 is a BCKDC kinase (BDK) inhibitor with an IC₅₀ of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC) . BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a K_i value of 59 μM .

HY-NP008

β-Lactoglobulin	Lipocalin Family	Inflammation/Immunology
β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-P3479

Insulin (swine)	Insulin Receptor	Metabolic Disease
Insulin (swine) is an orally active insulin derived from pigs. Insulin (swine) when administered orally acts as an antigen to reduce the severity of pancreatic lymphocyte infiltration, but has no metabolic effect on blood glucose levels. Insulin (swine) increases glucose oxidation, stimulates lipogenesis, and lowers blood glucose levels. Insulin (swine) can be used in diabetes research .

HY-W193545A

ERG240 5 Publications Verification	Aminotransferases (Transaminases)	Inflammation/Immunology Cancer
ERG240 is an oral active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor. ERG240 can be used for the research of cancer, rheumatoid arthritis, and bone disease .

HY-B1122

L-Cycloserine 2 Publications Verification (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	GABA Receptor HIV	Neurological Disease Cancer
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .

HY-N0486S9

L-Leucine-d3 3 Publications Verification	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S1

L-Leucine-13C	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-141669

BCAT-IN-2 5 Publications Verification	Aminotransferases (Transaminases)	Metabolic Disease
BCAT-IN-2 is a potent, selective and orally active inhibitor of *mitochondrial branched-chain* aminotransferase (BCATm), with a pIC₅₀ of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC₅₀**=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema .

HY-159648

PF-07328948	Endogenous Metabolite	Cardiovascular Disease
PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC₅₀ of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats .

HY-N0486R

L-Leucine (Standard) 1 Publications Verification Leucine (Standard)	Reference Standards mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-148242

BAY-069 3 Publications Verification	Fluorescent Dye	Cancer
BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC₅₀ values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer .

HY-116044

BCATc Inhibitor 2 5+ Cited Publications	Aminotransferases (Transaminases)	Neurological Disease
BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC₅₀s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm .

HY-B1876

Nicosulfuron	Environmental Pollutants Acetolactate Synthase (ALS)	Others
Nicosulfuron is efficient, harmless, antifungal and selective herbicide belonging to the sulfonylurea family. Nicosulfuron is also a photosynthetic system inhibitor and inhibits acetolactate synthase (ALS) enzyme activity. Nicosulfuron degradation by Plectosphaerella cucumerina AR1 is glucose concentration dependent in planktonic lifestyle. Nicosulfuron enhances the glycolysis pathway and tricarboxylic acid cycle to improve the adaptability of sweet maize. Nicosulfuron reduces the synthesis of branched-chain amino acids (BCAAs), which is proming for maize cultivation .

HY-W015874

2-Hydroxy-2-methylbutanoic acid	Endogenous Metabolite	Metabolic Disease
2-Hydroxy-2-methylbutanoic acid is a branched-chain fatty acid. 2-Hydroxy-2-methylbutanoic acid accumulates at high levels in the culture supernatants of colorectal cancer-associated bacteria. 2-Hydroxy-2-methylbutanoic acid is also present in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease .

HY-P11285A

LAGIPRA peptide TFA Long acting GIPRA-1 TFA	Insulin Receptor	Metabolic Disease
LAGIPRA peptide TFA is a long-acting GIP1R agonist. LAGIPRA peptide TFA enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide TFA has the potential for the research of type 2 diabetes .

HY-148242A

BAY-252	Fluorescent Dye	Cancer
BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC₅₀s of 2 μM and 2 μM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used for the research of cancer .

HY-N0486S

L-Leucine-d10 1 Publications Verification	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S2

L-Leucine-13C6	mTOR Endogenous Metabolite	Metabolic Disease
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-B0869A

Bispyribac sodium	Environmental Pollutants SOD Acetolactate Synthase (ALS) Herbicide	Metabolic Disease
Bispyribac sodium is a selective, orally active, systemic and post-emergence herbicide. Bispyribac sodium reduces SOD levels and inhibits ALS activity. Bispyribac sodium blocks the biosynthesis of branched-chain amino acids, resulting in growth retardation, chlorosis and necrosis of weeds. Bispyribac sodium exerts herbicidal activity against grass, sedge and broadleaf weeds in rice fields. Bispyribac sodium is hepatotoxic and genotoxic .

HY-W010516

2-Methylvaleric acid 2-Methylpentanoic acid	Endogenous Metabolite	Metabolic Disease
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-156193

PF-07208254	PDHK	Cardiovascular Disease Metabolic Disease
PF-07208254 is a selective, orally active allosteric inhibitor of branched-chain ketoacid dehydrogenase kinase (BDK) (IC₅₀=110 nM, K_i=54 nM, K_D=84 nM). PF-07208254 inhibits BDK-mediated BCKDH phosphorylation and enhances the catabolism of branched-chain amino acids (BCAAs) and branched-chain keto acids (BCKAs) by binding to the allosteric pocket of BDK, reducing BDK binding to BCKDH-E2 and promoting BDK degradation. PF-07208254 inhibits BDK activity in human skeletal muscle cells (IC₅₀=540 nM) and has activity to improve cardiac function and metabolism. PF-07208254 can be used in the study of cardiometabolic diseases (e.g., heart failure, type 2 diabetes) .

HY-N0771R

L-Isoleucine (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Apoptosis	Cancer
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-164093

Isovaleryl-CoA Isovaleryl-coenzyme A	Acetyl-CoA synthetase	Metabolic Disease
Isovaleryl-CoA sodium is a branched-chain acyl-CoA and an inhibitor of succinate-CoA ligase (SCL), with an IC₅₀ of 273 μM in rat liver mitochondria .

HY-N0486S8

L-Leucine-13C6,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S6

L-Leucine-2-13C,15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-155157

PF-07247685	Endogenous Metabolite	Cardiovascular Disease
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC₅₀=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-128371

2-Methylhexanoic acid	Biochemical Assay Reagents	Others
2-Methylhexanoic acid is a saturated branched-chain carboxylic acid with a strong "fatty" or "oily" odor. At high concentrations, it is often described as having the smell of lard, chicken fat or sweat; when diluted, it exhibits a dairy, cream or cheese aroma. Therefore, it is commonly used in the formulation of milk, meat (pork/chicken) and baked food flavors. 2-Methylhexanoic acid occurs naturally in fresh apples, cheese, grape brandy, lamb, potatoes and tea .

HY-W015307

4-Ethyloctanoic acid	Drug Derivative	Others
4-Ethyloctanoic acid is a branched chain aliphatic carboxylic acid that can be found in blue cheeses, various cheese types, and lamb/mutton. 4-Ethyloctanoic acid is a fragrance ingredient .

HY-P11285

LAGIPRA peptide Long acting GIPRA-1	Insulin Receptor	Metabolic Disease
LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes .

HY-N15936

a15:0-i15:0 PE	Toll-like Receptor (TLR) Interleukin Related	Inflammation/Immunology
a15:0-i15:0 PE is a diacyl phosphatidylethanolamine with two branched chains. a15:0-i15:0 PE is a non-canonical TLR2-TLR1 heterodimer agonist and has immunogenic activity. a15:0-i15:0 PE activates T cells and DC signaling and shows anti-inflammatory activity. a15:0-i15:0 PE induces TNFα and IL-6 production. a15:0-i15:0 PE is a the major component (approximately 50%) of A. muciniphila’s lipid membrane .

HY-164093A

Isovaleryl-CoA sodium	Acetyl-CoA synthetase	Others
Isovaleryl-CoA sodium, a branched-chain acyl CoA, is a succinate:CoA ligase (SCL) inhibitor with an IC₅₀ of 273 μM in rat liver mitochondria .

HY-N0486S4

L-Leucine-d7	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S3

L-Leucine-15N	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-122950

Harzianic acid	Fungal	Infection
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide .

HY-P3432

DfTat	Biochemical Assay Reagents	Others
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .

HY-W015667

Ethyl 2-methylpentanoate Ethyl 2-methylvalerate	Environmental Pollutants Biochemical Assay Reagents	Others
Ethyl 2-methylpentanoate is a class of esters consisting of branched-chain isovaleric acid esterified with ethanol. The compound has a fruity, pungent smell and is commonly used as a flavoring in foods such as baked goods, dairy products and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Ethyl 2-methylpentanoate can be used as a starting material for the synthesis of other organic compounds.

HY-N0486S12

L-Leucine-d2	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S10

L-Leucine-18O2	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W654264

2-Methylbutyrylcarnitine chloride	Endogenous Metabolite Integrin	Cardiovascular Disease
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .

HY-P4668

Valylleucine Val-Leu; H-Val-Leu-OH	Bacterial	Infection
Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .

HY-P4668A

Valylleucine TFA Val-Leu TFA; H-Val-Leu-OH TFA	Bacterial	Infection
Valylleucine (Val-Leu; H-Val-Leu-OH) TFA is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine TFA, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .

HY-121950

18-Methyleicosanoic acid	Biochemical Assay Reagents	Others
18-Methyleicosanoic acid is a branched-chain fatty acid. 18-Methyleicosanoic acid has a hydrophobic surface and can act as a boundary lubricant .

HY-W014206

Isopentyl octanoate	Biochemical Assay Reagents	Others
Isopentyl octanoate is a class of esters formed by the esterification of branched-chain isoamyl alcohol, also known as isoamyl alcohol, with octanoylate. The compound has a fruity smell and is commonly used as a flavoring in foods such as baked goods, candy and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Isopentyl octanoate can be used as a starting material for the synthesis of other organic compounds.

HY-P10204

FZD7 antagonist 1	Wnt	Cancer
FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC₅₀ value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors .

HY-169061

WQQ-345	Histone Methyltransferase Aminotransferases (Transaminases) Lactate Dehydrogenase	Cancer
WQQ-345 is an orally active BCAT1 inhibitor with an IC₅₀ values of 10.8 mM. WQQ-345 reduces cellular α-KG levels, upregulating H3K27me3 expression, decreasing glycolytic enzyme expression, and impairing glycolysis activity. WQQ-345 reduces colony formation, suppresses growth of BCAT1-high TKI-resistant lung cancer cells. WQQ-345 exerts in vitro and in vivo antitumor activity. WQQ-345 can be used for the research of TKI-resistant non-small cell lung cancer and TKI-resistant lung cancer .

HY-N0486S11

L-Leucine-d1	mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S5

L-Leucine-2-13C	Isotope-Labeled Compounds mTOR Endogenous Metabolite	Metabolic Disease
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

Cat. No.	Product Name

HY-L227

Amino Acid Metabolite Compound Library

198 compounds

Amino acids are the fundamental components that sustain life activities, playing roles in ATP generation, promoting nucleotide synthesis, and maintaining cellular redox balance. Moreover, dysregulation of amino acid consumption is a significant potential regulatory mechanism leading to impaired anti-tumor immunity in immune cells. The normal functioning of immune cells relies on amino acid metabolic pathways to obtain energy and materials, and upon activation, they reprogram their metabolism to support growth, proliferation, and effector functions. Additionally, metabolic disorders of specific amino acids (such as branched-chain amino acids, glutamine, and arginine) can exacerbate mitochondrial dysfunction and oxidative stress, thereby promoting myocardial fibrosis and cardiac cell damage. Therefore, conducting research related to amino acid metabolism holds promise for discovering potential drugs for diseases related to cancer, immunity, and metabolism.

MCE can provide 198 kinds of metabolites of amino acid metabolic pathways, which can be used for drug screening in various diseases such as cancer, immune disorders, metabolic diseases, mitochondrial-targeted diseases

Cat. No.	Product Name	Type

HY-NP008

β-Lactoglobulin

Biochemical Assay Reagents

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-W015667

Ethyl 2-methylpentanoate

Ethyl 2-methylvalerate

Biochemical Assay Reagents

Ethyl 2-methylpentanoate is a class of esters consisting of branched-chain isovaleric acid esterified with ethanol. The compound has a fruity, pungent smell and is commonly used as a flavoring in foods such as baked goods, dairy products and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Ethyl 2-methylpentanoate can be used as a starting material for the synthesis of other organic compounds.

HY-W127484

Isopalmitic acid 14-Methylpentadecanoic acid	Biochemical Assay Reagents
14-Methylpentadecanoic acid is a branched-chain fatty acid that has been found in soil bacteria. 1,2

HY-W014206

Isopentyl octanoate

Biochemical Assay Reagents

Isopentyl octanoate is a class of esters formed by the esterification of branched-chain isoamyl alcohol, also known as isoamyl alcohol, with octanoylate. The compound has a fruity smell and is commonly used as a flavoring in foods such as baked goods, candy and beverages. It can also be used as a fragrance ingredient in personal care products, and as a solvent or plasticizer in various industrial applications. In addition, Isopentyl octanoate can be used as a starting material for the synthesis of other organic compounds.

Cat. No.	Product Name	Target	Research Area

HY-P3479

Insulin (swine)	Insulin Receptor	Metabolic Disease
Insulin (swine) is an orally active insulin derived from pigs. Insulin (swine) when administered orally acts as an antigen to reduce the severity of pancreatic lymphocyte infiltration, but has no metabolic effect on blood glucose levels. Insulin (swine) increases glucose oxidation, stimulates lipogenesis, and lowers blood glucose levels. Insulin (swine) can be used in diabetes research .

HY-P11285A

LAGIPRA peptide TFA Long acting GIPRA-1 TFA	Insulin Receptor	Metabolic Disease
LAGIPRA peptide TFA is a long-acting GIP1R agonist. LAGIPRA peptide TFA enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide TFA has the potential for the research of type 2 diabetes .

HY-P11285

LAGIPRA peptide Long acting GIPRA-1	Insulin Receptor	Metabolic Disease
LAGIPRA peptide is a long-acting GIP1R agonist. LAGIPRA peptide enhances insulin sensitivity by augmenting glucose disposal and reduces branched-chain amino acids (BCAAs) and ketoacids. LAGIPRA peptide has the potential for the research of type 2 diabetes .

HY-112173

Prolylleucine 4 Publications Verification Z-Pro-D-Leu-OH	Peptides	Cardiovascular Disease Neurological Disease
Prolylleucine (Z-Pro-D-Leu) is a dipeptide containing branched-chain amino acids. Prolylleucine (Z-Pro-D-Leu) can affect the circadian rhythms and behaviour of animals .

HY-P3432

DfTat	Biochemical Assay Reagents	Others
DfTat is a dimer of the prototypical cell-penetrating peptide TAT. DfTat can deliver small molecules, peptides and proteins into live cells with a particularly high efficiency. DfTat labeled with the rhodamine can be used as a tracer for easy detection .

HY-P4668

Valylleucine Val-Leu; H-Val-Leu-OH	Bacterial	Infection
Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .

HY-P4668A

Valylleucine TFA Val-Leu TFA; H-Val-Leu-OH TFA	Bacterial	Infection
Valylleucine (Val-Leu; H-Val-Leu-OH) TFA is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine TFA, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .

HY-P10204

FZD7 antagonist 1	Wnt	Cancer
FZD7 antagonist 1 (peptide 34) is a dFz7-21 analogue. FZD7 antagonist 1 is an FZD7 antagonist that inhibits the wnt3a with IC₅₀ value of 9.2 nM. FZD7 antagonist 1 blocks TcdB−FZD interaction via targeting FZD receptors .

HY-P11361

Des B30 Insulin	Peptides	Metabolic Disease
Des B30 Insulin is a bioactive insulin analogue lacking the B30 amino acid residue. Des B30 Insulin can be used for the study of diabetes .

HY-P4890

Relaxin H3 (human)	RXFP Receptor	Neurological Disease
Relaxin H3 (human) is a kind of relaxin peptide. Relaxin H3 (human) exerts antifibrotic actions via RXFP1 .

HY-P10693

CZEN-002	TNF Receptor Bacterial	Infection Inflammation/Immunology
CZEN-002 is a derivative of alpha-melanocyte-stimulating hormone that has anti-inflammatory and antibacterial properties, inhibiting the production of TNF-α .

HY-P11246

A13:B7-24-GG	RXFP Receptor	Metabolic Disease
A13:B7-24-GG is an engineered analogue of insulin-like peptide 5 (INSL5), a selective RXFP4 agonist with a K_i value of 2.29 nM. A13:B7-24-GG has an extremely low binding affinity for RXFP3 (K_i = 602.56 nM) and an inhibitory effect on cAMP (EC₅₀) of 1.17 nM. Activation of RXFP4 by A13:B7-24-GG leads to the recruitment of β-Arrestin2, with an EC₅₀ of 22.39 nM. A13:B7-24-GG can be used for research on chronic constipation .

HY-P10007

Z-Gly-Pro-Phe-Leu-CHO Z-GPFL-CHO	Proteasome	Cancer
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor (K_i = 1.5 µM for branched chain amino acid preferring, 2.3 µM for small neutral amino acid preferring, and 40.5 µM for chymotrypsin-like activities; IC₅₀ = 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity) .

HY-P4062

Insulin peglispro BIL	Insulin Receptor	Metabolic Disease
Insulin peglispro (BIL) is a basal insulin with a flat, prolonged activity profile. Insulin peglispro can exhibit better glycaemic control compared to conventional insulins .

HY-P2124R

Cyclo(L-Trp-L-Trp) (Standard)	Reference Standards Antibiotic Bacterial	Infection
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-P4890A

Relaxin H3 (human) TFA	RXFP Receptor	Neurological Disease
Relaxin H3 (human) (TFA) is a kind of relaxin peptide. Relaxin H3 (human) (TFA) exerts antifibrotic actions via RXFP1 .

HY-P1372

PKC ζ pseudosubstrate	PKC	Others
PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide .

HY-P1371

Pseudo RACK1 KKWKMRRNQFWIKIQRC CSVEIWD*	PKC	Others
Pseudo RACK1, a peptide, is a PKC agonist with homologous sequences of PKC. Pseudo RACK1 interacts selectively with β-PKC at an autoregulatory site (RACK-binding site) and activates it in the absence of PKC activators, following inducing PKC-mediated histone phosphorylation .

HY-P10014

Bibapcitide	Peptides	Cardiovascular Disease
Bibapcitide, a 26 amino acid, inhibits thrombosis .

HY-P11548

Rattusin	Bacterial	Infection
Rattusin is an antimicrobial peptide. Rattusin exerts bactericidal activity by damaging membrane integrity. Rattusin can be used for antimicrobial research .

HY-P11625

R9-13	RXFP Receptor	Cardiovascular Disease
R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0486

L-Leucine 15+ Cited Publications Leucine	Structural Classification Metabolic Disease Amino acids Endogenous metabolite Source Classification	mTOR Endogenous Metabolite Ligands for E3 Ligase
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0771

L-Isoleucine 5+ Cited Publications	Classification of Application Fields Endocrine diseases Amino acids Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms other families Disease markers Other Diseases Nervous System Disorder Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-B1122

L-Cycloserine 2 Publications Verification (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification Cancer	GABA Receptor HIV
L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains .

HY-N0486R

L-Leucine (Standard) 1 Publications Verification Leucine (Standard)	Structural Classification Zea mays L. Endocrine diseases Amino acids Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Gramineae Disease markers Nervous System Disorder Cardiovascular System Disorder Source Classification	Reference Standards mTOR Endogenous Metabolite
L-Leucine (Standard) is the analytical standard of L-Leucine. This product is intended for research and analytical applications. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-W015874

2-Hydroxy-2-methylbutanoic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Hydroxy-2-methylbutanoic acid is a branched-chain fatty acid. 2-Hydroxy-2-methylbutanoic acid accumulates at high levels in the culture supernatants of colorectal cancer-associated bacteria. 2-Hydroxy-2-methylbutanoic acid is also present in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease .

HY-W010516

2-Methylvaleric acid 2-Methylpentanoic acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-156193

PF-07208254	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	PDHK
PF-07208254 is a selective, orally active allosteric inhibitor of branched-chain ketoacid dehydrogenase kinase (BDK) (IC₅₀=110 nM, K_i=54 nM, K_D=84 nM). PF-07208254 inhibits BDK-mediated BCKDH phosphorylation and enhances the catabolism of branched-chain amino acids (BCAAs) and branched-chain keto acids (BCKAs) by binding to the allosteric pocket of BDK, reducing BDK binding to BCKDH-E2 and promoting BDK degradation. PF-07208254 inhibits BDK activity in human skeletal muscle cells (IC₅₀=540 nM) and has activity to improve cardiac function and metabolism. PF-07208254 can be used in the study of cardiometabolic diseases (e.g., heart failure, type 2 diabetes) .

HY-N0771R

L-Isoleucine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Disease markers Endocrine diseases Amino acids Nervous System Disorder Plants Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
L-Isoleucine (Standard) is the analytical standard of L-Isoleucine. This product is intended for research and analytical applications. L-Isoleucine is an orally active branched chain amino acid, which is the L-enantiomer of isoleucine. L-Isoleucine has a role as a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a plant metabolite, a human metabolite, an algal metabolite and a mouse metabolite. L-Isoleucine regulates the inflammatory response to protect against pathogens in vivo and in vitro .

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Classification of Application Fields Leguminosae Glycine max (L.) merr Ketones, Aldehydes, Acids Plants Disease Research Fields Cancer Source Classification	Apoptosis
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-155157

PF-07247685	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC₅₀=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-W015307

4-Ethyloctanoic acid	Structural Classification Nicotiana tabacum L. Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Solanaceae Plants Disease Research Fields Source Classification	Drug Derivative
4-Ethyloctanoic acid is a branched chain aliphatic carboxylic acid that can be found in blue cheeses, various cheese types, and lamb/mutton. 4-Ethyloctanoic acid is a fragrance ingredient .

HY-W654264

2-Methylbutyrylcarnitine chloride	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Integrin
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin α2β1 in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .

HY-155156

PF-07238025	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC₅₀=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-B1122R

L-Cycloserine (Standard) (S)-Cycloserine (Standard); (S)-4-Amino-3-isoxazolidone (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards GABA Receptor HIV
L-Cycloserine (Standard) is the analytical standard of L-Cycloserine. This product is intended for research and analytical applications. L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

HY-W010516R

2-Methylvaleric acid (Standard) 2-Methylpentanoic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-W143057

2-Methylhexadecanoic acid	Structural Classification Natural Products other families Coniogramme japonica (Thunb.) Diels Plants Source Classification	Biochemical Assay Reagents
2-Methylhexadecanoic acid is a C17 branched-chain fatty acid and can be used as a branched fatty acid feedstock for transesterification .

HY-W012346

Geranyl isobutyrate	Structural Classification Natural Products Animals Source Classification	Drug Derivative Bacterial
Geranyl isobutyrate is a synthetic α,β‑unsaturated branched‑chain aliphatic ester and a geraniol derivative. Geranyl isobutyrate acts as a food and feed flavouring agent and a biologically active antimicrobial compound. Geranyl isobutyrate shows antimicrobial activity against Gram‑positive and most Gram‑negative bacteria .

HY-W015307R

4-Ethyloctanoic acid (Standard)	Structural Classification Nicotiana tabacum L. Ketones, Aldehydes, Acids Solanaceae Plants Source Classification	Reference Standards
4-Ethyloctanoic acid (Standard) is the analytical standard of 4-Ethyloctanoic acid (HY-W015307). This product is intended for research and analytical applications. 4-Ethyloctanoic acid is a branched chain aliphatic carboxylic acid that can be found in blue cheeses, various cheese types, and lamb/mutton. 4-Ethyloctanoic acid is a fragrance ingredient .

Species:	Human (8)
Tag:	His (4) Strep (3) Tag Free (3) GST (1)
Source:	Sf9 insect cells (2) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74207

	DBT Protein, Human (sf9, His) Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex; BCKAD-E2; DBT	Human	Sf9 insect cells
	DBT proteins are components of the branched-chain α-keto dehydrogenase complex, which catalyzes the conversion of α-keto acids into acyl-CoA and CO(2). This complex includes branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2), and lipoamide dehydrogenase (E3). DBT Protein, Human (sf9, His) is the recombinant human-derived DBT protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P702948

	BCKDK Protein, Human (sf9, GST) branched-chain alpha-ketoacid dehydrogenase kinase; BCKDH kinase; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase; mitochondrial	Human	Sf9 insect cells
	BCKDK Protein, Human (sf9, GST) is the recombinant human-derived BCKDK, expressed by Sf9 insect cells , with GST labeled tag.

HY-P703609

	BCKDK Protein, Human branched-chain alpha-ketoacid dehydrogenase kinase; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; 2.7.11.4; BCKDK; Homo sapiens; Human; Kinase; Transferase; 2.7.11.1	Human	E. coli
	BCKDK Protein, Human is the recombinant human-derived BCKDK, expressed by E. coli, with tag free labeled tag.

HY-P703610

	BCKDK Protein, Human (His, Strep) branched-chain alpha-ketoacid dehydrogenase kinase; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; 2.7.11.4; BCKDK; Homo sapiens; Human; Kinase; Transferase; 2.7.11.1	Human	E. coli
	BCKDK Protein, Human (His, Strep) is the recombinant human-derived BCKDK, expressed by E. coli, with Strep, His labeled tag.

HY-P701337

	BCAT1 Protein, Human BCAT1; branched-chain-amino-acid aminotransferase; cytosolic; BCAT(c); Protein ECA39	Human	E. coli
	The BCAT1 protein plays a key role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic pathways necessary for energy production and nitrogen balance. BCAT1 Protein, Human is the recombinant human-derived BCAT1 protein, expressed by E. coli , with tag free.

HY-P701338

	BCAT1 Protein, Human (His, StrepⅡ) BCAT1; branched-chain-amino-acid aminotransferase; cytosolic; BCAT(c); Protein ECA39	Human	E. coli
	The BCAT1 protein plays a key role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic pathways necessary for energy production and nitrogen balance. BCAT1 Protein, Human (His, Strep) is the recombinant human-derived BCAT1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P701339

	BCAT2 Protein, Human BCAT2; branched-chain-amino-acid aminotransferase; mitochondrial; BCAT(m); Placental protein 18; PP18	Human	E. coli
	Various studies have demonstrated that the BCAT2 protein plays a critical role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic processes necessary for energy production and nitrogen balance. BCAT2 Protein, Human is the recombinant human-derived BCAT2 protein, expressed by E. coli , with tag free.

HY-P701340

	BCAT2 Protein, Human (His, StrepII) BCAT2; branched-chain-amino-acid aminotransferase; mitochondrial; BCAT(m); Placental protein 18; PP18	Human	E. coli
	Various studies have demonstrated that the BCAT2 protein plays a critical role in cellular processes as it catalyzes the initial reactions in the catabolism of the essential branched-chain amino acids leucine, isoleucine, and valine. This enzyme activity is essential for the breakdown of these amino acids, contributing to metabolic processes necessary for energy production and nitrogen balance. BCAT2 Protein, Human (His, Strep) is the recombinant human-derived BCAT2 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

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Source
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Cat. No.	Product Name	Chemical Structure

HY-N0486S9

L-Leucine-d3 3 Publications Verification
L-Leucine-d₃ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S1

L-Leucine-13C
L-Leucine- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S

L-Leucine-d10 1 Publications Verification
L-Leucine-d₁₀ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S2

L-Leucine-13C6
Leucine- ¹³C₆ is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S8

L-Leucine-13C6,15N
L-Leucine- ¹³C₆, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S6

L-Leucine-2-13C,15N
L-Leucine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S4

L-Leucine-d7
L-Leucine-d₇ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S3

L-Leucine-15N
L-Leucine- ¹⁵N is the ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S12

L-Leucine-d2
L-Leucine-d₂ is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S10

L-Leucine-18O2
L-Leucine- ¹⁸O₂ is the ¹⁸O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S11

L-Leucine-d1
L-Leucine-d is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S5

L-Leucine-2-13C
L-Leucine-2- ¹³C is the ¹³C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S7

L-Leucine-1-13C,15N
L-Leucine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N0486S13

L-Leucine-15N,d10
L-Leucine- ¹⁵N,d₁₀ is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-131503S

13-Methyltetradecanoic acid-d6
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-I1060S

L-Alloisoleucine-d10
L-Alloisoleucine-d₁₀ is the deuterium labeled L-Alloisoleucine. L-Alloisoleucine is a branched chain amino acid and is a stereo-isomer of L-isoleucine. L-Alloisoleucine is a common constituent of human plasma (albeit at low levels).

HY-W015307S

4-Ethyloctanoic acid-13C2
4-Ethyloctanoic acid- ¹³C₂ is ¹³C labeled 4-Ethyloctanoic acid (HY-W015307). 4-Ethyloctanoic acid is a branched chain aliphatic carboxylic acid that can be found in blue cheeses, various cheese types, and lamb/mutton. 4-Ethyloctanoic acid is a fragrance ingredient .

HY-W721637

Foramsulfuron-d6-1
Foramsulfuron-d₆-1 is the deuterium labeled Foramsulfuron (HY-W422402). Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .

Host:	Rabbit (2)
Reactivity:	Human (2) mouse (1) Rat (1) Mouse (1) rat (1) Monkey (1)
Application:	WB IHC-P (1) WB (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Phosphorylated (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810471

	BCKDK Antibody BCKDK, branched chain Keto Acid Dehydrogenase Kinase, [3-Methyl-2-Oxobutanoate Dehydrogenase [Lipoamide]] Kinase, Mitochondrial, branched-chain Alpha-Ketoacid Dehydrogenase Kinase, BCKDH Kinase, EC 2.7.11.4, BCKDHKIN, BDK, 3-Methyl-2-Oxobutanoate Dehydrogenase [Lipoamide] Kinase, Mitochondrial, branched chain Alpha-Ketoacid Dehydrogenase Kinase, branched chain Ketoacid Dehydrogenase Kinase, BCKD-Kinase, EC 2.7.11.1, EC 2.7.11, BCKDKD	WB IHC-P	Human, mouse, rat
	BCKDK Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to BCKDK.

HY-P87194

	Phospho-BCKDHA (S293) Antibody (YA6882) branched chain alpha keto acid dehydrogenase E1 component alpha polypeptide antibody	WB	Human, Mouse, Rat, Monkey
	Phospho-BCKDHA (S293) Antibody (YA6882) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-BCKDHA (S293).

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-N0486

L-Leucine 15+ Cited Publications Leucine		Others
L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .

HY-N15936

a15:0-i15:0 PE		Phospholipids
a15:0-i15:0 PE is a diacyl phosphatidylethanolamine with two branched chains. a15:0-i15:0 PE is a non-canonical TLR2-TLR1 heterodimer agonist and has immunogenic activity. a15:0-i15:0 PE activates T cells and DC signaling and shows anti-inflammatory activity. a15:0-i15:0 PE induces TNFα and IL-6 production. a15:0-i15:0 PE is a the major component (approximately 50%) of A. muciniphila’s lipid membrane .

HY-160569

C14-SPM		Cationic Lipids
C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA .

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