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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
deoxycytidine kinase
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "deoxycytidine kinase" in MCE Product Catalog:
Cat. No.: HY-16496
CAS No.: 26599-17-7
Synonyms: OSI-7836
Target:
Research Areas:
Thiarabine (OSI-7836) is an orally active cytotoxic antitumor agent that acts as a deoxycytidine kinase substrate and a DNA chain terminator. Thiarabine is metabolized to form its major active metabolite T-araCTP, which potently inhibits DNA synthesis and exhibits a long retention time in tumor cells. Thiarabine is widely applicable to research related to leukemia, lymphoma, hematologic malignancies, acute myeloid leukemia, and advanced solid malignancies .
Cat. No.: HY-164840A
Target:
Research Areas:
Clofarabine-5'-triphosphate trisodium is the trisodium salt form of Clofarabine-5'-triphosphate (HY-164840). Clofarabine-5'-triphosphate trisodium is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate trisodium exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .
Cat. No.: HY-W009216R
CAS No.: 1032-65-1
Synonyms: 5'-dCMP (Standard); Deoxy-CMP (Standard); 2'-deoxycytidine-5'-monophosphoric acid (Standard)
Cat. No.: HY-14509
CAS No.: 1034174-88-3
Target:
Research Areas:
LP-661438 (Compound 10) is an orally active DCK inhibitor (IC50 = 1.7 nM). LP-661438 inhibits deoxycytidine kinase in T cells and in vivo .
Cat. No.: HY-65036
CAS No.: 36953-37-4
Synonyms: 4-Bromo-2-pyridone
Research Areas:
4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry .
Cat. No.: HY-E70630
Target:
Research Areas:
Deoxycytidine Kinase, Human (EC 2.7.1.74) is a rate-limiting enzyme in the de novo pathway. Deoxycytidine Kinase, Human captures extracellular deoxyribonucleosides for use in intracellular deoxyribonucleotide metabolism. Deoxycytidine Kinase, Human functions as a dimer in cells to phosphorylate deoxycytidine as its major substrate as well as deoxyadenosine and deoxyguanosine and can activate various nucleoside analogue therapeutics .
Cat. No.: HY-164840
CAS No.: 134646-41-6
Synonyms: Clofarabine-TP
Target:
Research Areas:
Clofarabine-5'-triphosphate is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .
Cat. No.: HY-W194107
CAS No.: 1209784-87-1
Target:
Research Areas:
Antitumor agent-152 (Compound 5) is a specific substrate and inhibitor of deoxycytidine kinase (dCK) with anticancer activity. Antitumor agent-152 can inhibit the uptake of 3H-dC in L1210 leukemia cells with an IC50 value of 1.12 μM .
Cat. No.: HY-164839
CAS No.: 167620-89-5
Synonyms: Clofarabine-DP
Target:
Research Areas:
Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .
Cat. No.: HY-164839A
Synonyms: Clofarabine-DP trisodium
Target:
Research Areas:
Clofarabine-5'-diphosphate trisodium (Clofarabine-DP trisodium) is the trisodium salt form of Clofarabine-5'-diphosphate (HY-164839). Clofarabine-5'-diphosphate trisodium is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate trisodium can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair .
Cat. No.: HY-W344074
CAS No.: 7075-11-8
Target:
Research Areas:
Cytarabine 5′-monophosphate is a metabolite of the nucleoside analog Cytarabine (HY-13605), catalyzed by deoxycytidine kinase. Cytarabine 5′-monophosphate is incorporated into DNA by DNA polymerase α, which reduces the rate of DNA synthesis. At a concentration of 15 mM, Cytarabine 5′-monophosphate inhibits nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae (S. cerevisiae). Additionally, Cytarabine 5′-monophosphate (3.5-75.1 mg/kg) improves survival in leukemia mice (L1210 mice). Cytarabine 5′-monophosphate can be used in cancer research .
Cat. No.: HY-P700584
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DCK; Deoxyadenosine kinase; deoxycytidine kinase; Deoxyguanosine kinase; Deoxynucleoside kinase
Species:
Human
Source:
P. pastoris
Cat. No.: HY-16496A
CAS No.: 1060763-87-2
Synonyms: OSI-7836 hydrochloride
Target:
Research Areas:
Thiarabine (OSI-7836) hydrochloride is an orally active cytotoxic antitumor agent that acts as a deoxycytidine kinase substrate and a DNA chain terminator. Thiarabine hydrochloride is metabolized to form its major active metabolite T-araCTP, which potently inhibits DNA synthesis and exhibits a long retention time in tumor cells. Thiarabine hydrochloride is widely applicable to research related to leukemia, lymphoma, hematologic malignancies, acute myeloid leukemia, and advanced solid malignancies .
Cat. No.: HY-P991883
Synonyms: Licartin; Metuximab; Mehuzumab
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
