134646-41-6
134646-41-6
Chemical Structure
Clofarabine-5'-triphosphate
Synonym(s): Clofarabine-TP
- CAS No.: 134646-41-6
- Formula:C10H14ClFN5O12P3
- Molecular Weight:543.62
InChIKey: ILZCVFJUTWHERD-AYQXTPAHSA-N
SMILES: NC1=NC(Cl)=NC2=C1N=CN2[C@H]3[C@@H](F)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3
Biological Activity: Clofarabine-5'-triphosphate is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair[1].
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Clofarabine-5'-triphosphate | Clofarabine-5'-triphosphate is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-triphosphate exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair. | |||||||||||||||||||||
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