36953-37-4
Chemical Structure
4-Bromo-2-hydroxypyridine
Synonym(s): 4-Bromo-2-pyridone
- CAS No.: 36953-37-4
- Formula:C5H4BrNO
- Molecular Weight:174.00
IUPAC Name: 4-bromopyridin-2-ol
InChIKey: SSLMGOKTIUIZLY-UHFFFAOYSA-N
SMILES: OC1=NC=CC(Br)=C1
Biological Activity: 4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Bromo-2-hydroxypyridine | 99.04% | 4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry. | ||||||||||||||||||||
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References
- [1]. Rudra A, et al. Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases. The Journal of organic chemistry. 2015 Nov 06;80(21):10675-85.
- [2]. Mistry SN, et al. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor. Journal of medicinal chemistry. 2016 Jan 14;59(1):388-409. [Content Brief]
- [3]. Jörg M, et al. Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M Muscarinic Acetylcholine Receptor. ChemMedChem. 2021 Jan 08;16(1):216-233. [Content Brief]
