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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
dopamine-beta-hydroxylase
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "dopamine-beta-hydroxylase" in MCE Product Catalog:
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3
3 Cited Publications
Synonyms: SYN-117 hydrochloride; RS-25560-197 hydrochloride
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Nepicastat hydrochloride (SYN-117 hydrochloride) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat hydrochloride produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat hydrochloride can cross the blood-brain barrier (BBB) .
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1 Cited Publications
Cat. No.: HY-W017113
CAS No.: 149-30-4
Synonyms: BIA 5-1058
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Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively . Zamicastat reduces high blood pressure .
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Guanoclor is an antihypertensive compound. Guanoclor is an adrenergic neurone-blocking agent, which also interferes with noradrenaline synthesis by inhibition of the enzyme dopamine beta-hydroxylase .
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U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes .
Cat. No.: HY-13289
CAS No.: 173997-05-2
Synonyms: SYN117; RS-25560-197
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Research Areas:
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .
Synonyms: BIA 5-453 hydrochloride
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Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM . Etamicastat can be used in the research of cardiovascular diseases .
Cat. No.: HY-14838
CAS No.: 760173-05-5
Synonyms: BIA 5-453
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Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM . Etamicastat can be used in the research of cardiovascular diseases .
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EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P2 phosphatase and Ins(1,4,5)P3 5-phosphatase. EWP 815 also inhibits enzyme dopamine β-hydroxylase activity .
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Cat. No.: HY-W204613
CAS No.: 1446-24-8
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3-Allylphenol is an inhibitor of dopamine β-hydroxylase with a Ki value of 12 mM .
Cat. No.: HY-W1030828
CAS No.: 95333-81-6
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SKF-102698 is a dopamine β-hydroxylase inhibitor. SKF 102698 increases endogenous dopamine levels. SKF-102698 can be used in hypertension research .
Cat. No.: HY-13289B
CAS No.: 195881-94-8
Synonyms: (R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride
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(R)-Nepicastat hydrochloride is the isomer of Nepicastat (HY-13289). Nepicastat (SYN117) is a selective，potent，and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .
Cat. No.: HY-156989
CAS No.: 55769-65-8
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Butobendine, a double ester of 2-aminobutanol and trimethoxybenzoic acid, is an antiarrhythmic agent . Butobendine is a noncompetitive inhibitor of dopamine β-hydroxylase (DBH) .
Cat. No.: HY-P810788
Synonyms: dopamine beta-hydroxylase, dopamine beta-monooxygenase
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
