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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
endoribonuclease
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "endoribonuclease" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM) .
1
1 Cited Publications
Cat. No.: HY-U00460
3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer .
1
1
IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease . HBx: hepatitis B virus X protein.
Cat. No.: HY-U00460B
CAS No.: 2226511-77-7
3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer .
Cat. No.: HY-151113
CAS No.: 1135190-41-8
ZINC000104379474 is a compound that targets SARS-CoV-2 endoribonuclease .
Cat. No.: HY-162956
CAS No.: 364338-71-6
SARS-CoV-2-IN-97 (Compound CO-01) is an inhibitor for SARS-CoV-2 Nsp15 endoribonuclease with an IC50 of 53.5 μM. SARS-CoV-2-IN-97 exhibits low cytotoxicity in A549-AT cell with IC50 of 134 μM .
Cat. No.: HY-121492
CAS No.: 1414586-62-1
Target:
Research Areas:
NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC50 value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer .
Cat. No.: HY-183761
Target:
Research Areas:
Antiviral agent 86 is an anti-coronavirus agent. Antiviral agent 86 acts as a binder of coronavirus non-structural protein 15 (nsp15), with a Kd value of 67 μM against human targets. Antiviral agent 86 inhibits the replication of HCoV-229E and SARS-CoV-2. Antiviral agent 86 exerts inhibitory effects at the post-entry lifecycle stage of coronaviruses in host cells and inhibits the formation of viral double-stranded RNA (dsRNA). Antiviral agent 86 exhibits an additive antiviral effect when used in combination with GS-441524. Antiviral agent 86 can be used in studies related to coronavirus infections .
Cat. No.: HY-P706002
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ZC3H12A; Zinc Finger CCCH‑Type Containing 12A; Regnase‑1; MCPIP1; Monocyte Chemotactic Protein‑Induced Protein 1; Zinc Finger CCCH Domain‑Containing Protein 12A; endoribonuclease ZC3H12A; MCP‑Induced Protein 1; FLJ23231; MCPIP‑1; MCPIP; Reg1; Bifunctional endoribonuclease And Deubiquitinase ZC3H12A; MCP‑1 Treatment‑Induced Protein; MCP Induced Protein 1; Ribonuclease ZC3H12A; DJ423B22.1
Species:
Human
Source:
E. coli
Cat. No.: HY-P80828A
Synonyms: ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
Cat. No.: HY-P73858
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ERN1; Ire1-Alpha; Endoplasmic Reticulum To Nucleus Signaling 1; HIRE1p; IRE1; IRE1a; Serine/Threonine-Protein Kinase/endoribonuclease IRE1; Endoplasmic Reticulum-To-Nucleus Signaling 1; IRE1P; Non-Specific Serine/Threonine Protein Kinase; Inositol-Requiri
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703611
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: ERN2; HIRE2p; Endoplasmic Reticulum To Nucleus Signaling 2; Endoplasmic Reticulum To Nucleus Signalling 2; IRE1b; IRE1, S. Cerevisiae, Homolog Of; Serine/Threonine-Protein Kinase/endoribonuclease IRE2; Inositol-Requiring 1 Beta; Inositol-Requiring Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71462
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ZC3H12A; MCPIP-1; Zinc Finger CCCH-Type Containing 12A; MCPIP; Regnase-1; Reg1; MCPIP1; Bifunctional endoribonuclease And Deubiquitinase ZC3H12A; Monocyte Chemotactic Protein-Induced Protein 1; MCP-1 Treatment-Induced Protein; Zinc Finger CCCH Domain-Cont
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P73256
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ERN1; Ire1-Alpha; Endoplasmic Reticulum To Nucleus Signaling 1; HIRE1p; IRE1; IRE1a; Serine/Threonine-Protein Kinase/endoribonuclease IRE1; Endoplasmic Reticulum-To-Nucleus Signaling 1; IRE1P; Non-Specific Serine/Threonine Protein Kinase; Inositol-Requiri
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P77173
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ZC3H12A; MCPIP-1; Zinc Finger CCCH-Type Containing 12A; MCPIP; Regnase-1; Reg1; MCPIP1; Bifunctional endoribonuclease And Deubiquitinase ZC3H12A; Monocyte Chemotactic Protein-Induced Protein 1; MCP-1 Treatment-Induced Protein; Zinc Finger CCCH Domain-Cont
Species:
Rat
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
