1. Anti-infection
  2. HBV
  3. IR415

IR415 

Cat. No.: HY-116999
Handling Instructions

IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. HBx: hepatitis B virus X protein.

For research use only. We do not sell to patients.

IR415 Chemical Structure

IR415 Chemical Structure

CAS No. : 452967-14-5

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Description

IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease[1]. HBx: hepatitis B virus X protein.

IC50 & Target

Kd: 2 nM (IR415-HBx interaction)[1]

In Vitro

Hepatitis B virus X protein (HBx) as a suppressor of host defenses consisting of RNAi-based silencing of viral genes[1].
IR415 (50-200 μM) has a dose-dependent inhibitory effect on HBx, with a minimal effective concentration of 50 μM in HepG2/GFP-shRNA line transfected with HBx[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

296.34

Formula

C₁₃H₁₄F₂N₄S

CAS No.

452967-14-5

SMILES

S=C(NCCCN1C=CN=C1)NC2=CC=C(F)C=C2F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

IR415IR 415IR-415HBVHepatitis B virusHBXreplicationhepatitis BvirusHepG2cellVSRInhibitorinhibitorinhibit

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IR415
Cat. No.:
HY-116999
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