452967-14-5
452967-14-5
Chemical Structure
IR415
- CAS. Nr.: 452967-14-5
- Formula:C13H14F2N4S
- Molecular Weight:296.34
IUPAC Name: 1-(3-(1H-imidazol-1-yl)propyl)-3-(2,4-difluorophenyl)thiourea
InChIKey: KRSBPLFMLHNMPU-UHFFFAOYSA-N
SMILES: S=C(NCCCN1C=CN=C1)NC2=CC=C(F)C=C2F
Biological Activity: IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease[1]. HBx: hepatitis B virus X protein.
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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IR415 | 98.11% | IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity. IR415 selectively interacts with HBx (Kd=2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. HBx: hepatitis B virus X protein. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.73
HY-119173PBD-150 -
Similarity Score 0.61
HY-111798AHeme Oxygenase-1-IN-1 hydrochloride -
Similarity Score 0.60
HY-111798Heme Oxygenase-1-IN-1 -
Similarity Score 0.58
HY-W1127311,6-Di(1H-imidazol-1-yl)hexane -
Similarity Score 0.58
HY-105752Loflucarban -
Similarity Score 0.56
HY-16151CR-3294 -
Similarity Score 0.56
HY-W4564481,12-Di(1H-imidazol-1-yl)dodecane -
Similarity Score 0.56
HY-149740WAY-354436 -
Similarity Score 0.56
HY-175345CYP3A4-IN-5 -
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