Search Result
Results for "
faecalis
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1077
-
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R-16341
|
Calcium Channel
Dopamine Receptor
Autophagy
Apoptosis
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Neurological Disease
Inflammation/Immunology
Cancer
|
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Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 μg/ml .
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- HY-100126
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Tubercidin
Maximum Cited Publications
8 Publications Verification
7-Deazaadenosine
|
Bacterial
DNA/RNA Synthesis
Influenza Virus
Antibiotic
|
Infection
|
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Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .
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- HY-B1256A
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Cefuroxime
Maximum Cited Publications
10 Publications Verification
Kefurox
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Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cancer
|
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Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
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-
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- HY-N8332
-
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Ox bile extract
|
Bacterial
DNA/RNA Synthesis
|
Infection
|
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Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens .
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- HY-B1256
-
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Beta-lactamase
Bacterial
Antibiotic
|
Infection
Cancer
|
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Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
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-
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- HY-N0656A
-
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mTOR
Bacterial
Autophagy
|
Infection
Inflammation/Immunology
Cancer
|
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(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
-
- HY-N10264
-
|
(+)-Avrainvillamide; CJ-17,665
|
Antibiotic
|
Infection
Cancer
|
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Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively .
|
-
-
- HY-N5009
-
|
|
Bacterial
|
Infection
|
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Thermopsine is a quinolone-type alkaloid. Thermopsine exhibits low to moderate anti-E. faecalis activity .
|
-
-
- HY-125733
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively .
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-
- HY-125728
-
|
|
Bacterial
Parasite
HCV
|
Infection
|
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Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM . Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively . Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum .
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-
- HY-N13668
-
|
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Antibiotic
Bacterial
|
Infection
|
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Rhodomyrtone is an antibiotic that can be found in the leaves of Rhodomyrtus tomentosa. Rhodomyrtone kills Gram-positive bacterial cells without causing bacteriolysis. Rhodomyrtone exhibits activity against a variety of Gram-positive bacteria, including Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus salivarius. Rhodomyrtone is applicable to studies related to bacterial infections .
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-
- HY-129434A
-
|
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Bacterial
|
Infection
|
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4aα,7α,7aα-Nepetalactone exhibits antibacterial activity, and inhibits Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Enterococcus faecalis.
|
-
-
- HY-N7652
-
|
|
Bacterial
Interleukin Related
|
Infection
Inflammation/Immunology
Cancer
|
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Terminolic acid is a pentacyclic triterpene glycoside and antibacterial agent. Terminolic acid can be isolated from Combretum racemosum. Terminolic acid inhibits proinflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6. Terminolic acid reduces IL-8. Terminolic acid has antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis with MICs ranging from 64 to 256 μg/mL. Terminolic acid is used in colon cancer research .
|
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- HY-N0129
-
-
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- HY-P5203
-
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EntK1
|
Bacterial
|
Infection
|
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Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets Enterococcus faecalis via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections .
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- HY-120397
-
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PROTAC Linkers
|
Infection
Cancer
|
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Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W587957
-
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Bacterial
Parasite
|
Infection
|
|
Gypsogenic acid is a triterpenoid acid that can be isolated from Miconia stenostachya and has antibacterial and trypanoidal activities. The MICs values of Gypsogenic acid for the oral bacterial pathogens Enterococcus faecalis, Streptococcus salivarius, Streptococcus haematococcus, Streptococcus mutans and sobrinus were 50-200 μg/mL. Gypsogenic acid can induce blood cortensite cleavage in isolated mice with IC50 56.6 μM .
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- HY-W099540
-
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Bacterial
|
Infection
|
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OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC50: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .
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-
- HY-N0983
-
|
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Bacterial
|
Inflammation/Immunology
|
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1,3,7-Trihydroxy-2-prenylxanthone, a xanthone, shows weaker antibacterial activity. 1,3,7-Trihydroxy-2-prenylxanthone exhibits the MIC values of 6.25 mg/ml against VREs strains (E. faecalis, E. faecium, and E. gallinarum) .
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- HY-126461
-
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Bacterial
Fungal
|
Infection
|
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Salazinic acid has antibacterial activity against bacteria and fungi. Salazinic acid does not show antibacterial activity against Listeria monocytogenes, Pseudomonas aeruginosa, Yersinia enterocolitica, and Enterococcus faecalis, but it does have antibacterial activity against Pseudomonas aeruginosa and Salmonella typhimurium .
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-
- HY-133191
-
|
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PROTAC Linkers
|
Infection
Cancer
|
|
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
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-
- HY-143326
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 83 (compound 17h) displays potent antibacterial activity against various vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 83 can significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. Antibacterial agent 83 is metabolically stable in human liver microsomes .
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- HY-175376
-
|
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Antibiotic
Bacterial
|
Infection
|
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QPyN16Th is an N-palmitoylated cationic thiazolidine antibiotic. QPyN16Th is selectively active against the Gram-positive bavteria E. faecalis, S. aureus and MRSA with an MIC of 1.95 μM over gram-negative bacteria. QPyN16Th can induce membrane permeabilization and depolarization and ROS production in MRSA. QPyN16Th increases the survival of zebrafish model of intramuscular MRSA infection .
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- HY-P10996
-
|
Human Neutrophil Peptide-4 TFA
|
Bacterial
SARS-CoV
|
Infection
|
|
Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candida albicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients .
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- HY-W923644
-
|
Aegelinol; (-)-Smyrinol
|
Bacterial
|
Infection
|
|
(-)-Decursinol (Aegelinol; (-)-Smyrinol) is a natural pyranocoumarin compound tant can be isolated from the roots of Apiaceae plants such as Ferulago campestris. (-)-Decursinol inhibits both Gram-positive bacteria (Staphylococcus aureus ATCC 13709, Enterococcus faecalis ATCC 14428) and Gram-negative bacteria (Salmonella typhii ATCC 19430, Enterobacter cloacae ATCC 10699, Enterobacter aerogenes ATCC 13048) with minimum inhibitory concentrations (MIC) ranging from 16 to 64 μg/mL. (-)-Decursinol possesses antioxidant activity. (-)-Decursinol can be used for the study of bacterial infections .
|
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- HY-W145053
-
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Sodium chloro(4-methylbenzenesulfonyl)azanide hydrate
|
Factor Xa
Bacterial
|
Infection
|
|
ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) is a common reagent in various synthetic processes. It has been used as a reagent in aminohydroxylation and allylic amination reactions, a nitrogen source in aziridination reactions of alkenes and alkenes, and deprotection of sulfur groups in sulfur-containing compounds. It has been used as a reagent in the synthesis of factor Xa inhibitors. ChloraMine-T hydrate (Sodium chloro(4-methylbenzenesulfonyl)azanide (hydrate)) (0.2% w/v) is also an antimicrobial agent that kills Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and Enterococcus cloacae.
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- HY-168960
-
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Reactive Oxygen Species (ROS)
Bacterial
|
Infection
|
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ROS inducer 8 (Compound 11g) is the inhibitor for glutathione (GSH), that induces the ROS accumulation in Enterococcus faecalis, thereby exhibiting antibacterial activity. ROS inducer 8 disrupts the biofilm, inhibits S. aureus and E. faecalis with MIC of 8 μg/mL and 2 μg/mL, exhibits post-antibiotic effect. ROS inducer 8 exhibits low hemolytic toxicity to sheep erythrocytes (HC50 > 1280 μg/mL) .
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- HY-125569
-
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Fungal
Antibiotic
|
Infection
|
|
Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively .
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- HY-N10561
-
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Bacterial
|
Infection
|
|
Wychimicin A is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin A shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
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- HY-170367
-
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Bacterial
|
Infection
|
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Antimicrobial agent-35 (Compound c9) exhibits antibacterial agent, that inhibits S. aureus, E. coli, E. faecalis, and S. maltophilia with MIC of 0.5-2 μg/mL. Antimicrobial agent-35 exhibits cytotoxicity against HT-22 with IC50 of 130.4 μg/mL .
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- HY-155282
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-
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- HY-N10560
-
|
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Bacterial
|
Infection
|
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Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
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-
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- HY-N9477
-
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Betulin-28-oxime
|
Drug Derivative
Bacterial
|
Infection
|
|
Betulinic aldehyde oxime (Compound 31) is a betulin (HY-N0083) derivative that has antimicrobial properties against E. aerogenes, E. coli, E. faecalis, P. aeruginosa, S. aureus, and C. albicans. Betulinic aldehyde oxime displays cytotoxicity towards hepatocytes, with an IC50 of 25 μM .
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- HY-130596
-
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Antibiotic
Bacterial
|
Infection
Cancer
|
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DC-86-M is an antibiotic, which can be isolated from Streptomyces luteogriseus. DC-86-M exhibits antibacterial activities against Bacillus subtilis, Staphylococcus aureus, Enterococcus faecalis, Vibrio anguillarum, and Proteus vulgaris, with MIC <1 μg/mL. DC-86-M exhibits antitumor activity against mouse sarcoma 180 with LD50 of 25 mg/kg .
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- HY-N14367
-
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Bacterial
|
Infection
|
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Fluoropolyoxin L has the inhibitory activity of Escherichia coli and Streptococcus faecalis .
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- HY-126806
-
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Antibiotic
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Cancer
|
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Pyrrofolic acid is a folate antagonist with a low activity as a folate antagonist for Streptococcus faecalis .
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- HY-P5554
-
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Bacterial
|
Infection
|
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cOB1 phermone, a bacterial sex pheromone, effectively inhibits multidrug-resistant Enterococcus faecalis V583 .
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-
-
- HY-N14416
-
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Antibiotic
Bacterial
|
Infection
|
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Parvodicin A is a glycopeptide antibiotic. Parvodicin A has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .
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- HY-129166
-
|
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Bacterial
|
Infection
|
|
UCM53, a FtsZ inhibitor, is an antibacterial agent. UCM53 can inhibit the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis
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-
-
- HY-N5181
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Parvodicin C3 is a glycopeptide antibiotic. Parvodicin C3 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .
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- HY-N15040
-
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|
Antibiotic
Bacterial
|
Infection
|
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Parvodicin C4 is a glycopeptide antibiotic. Parvodicin C4 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis .
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- HY-172109
-
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DNA/RNA Synthesis
|
Infection
|
|
DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis .
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- HY-B1077R
-
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R-16341 (Standard)
|
Reference Standards
Calcium Channel
Dopamine Receptor
Autophagy
Apoptosis
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Penfluridol (Standard) is the analytical standard of Penfluridol. This product is intended for research and analytical applications. Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 μg/ml .
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- HY-P10134
-
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Bacterial
|
Infection
|
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Salivaricin B is a broad-spectrum bacteriocin produced by Lactobacillus salivarius M7, capable of inhibiting the growth of Listeria monocytogenes, Bacillus cereus, Brochothrix thermosphacta, Enterococcus faecalis, and various lactobacilli .
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-
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- HY-W007161
-
|
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Bacterial
|
Infection
|
|
8-Desmethoxy-8-fluoro Moxifloxacin (Compound 07) is an antibacterial agent, and has bactericidal activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis .
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-
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- HY-N5195
-
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Nocathiacine II
|
Bacterial
|
Infection
|
|
Nocathiacin II (Nocathiacine II) is highly resistant to Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF) .
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-
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- HY-N5184
-
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Nocathiacine III
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Bacterial
|
Infection
|
|
Nocathiacin III (Nocathiacine III) is highly resistant to Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF) .
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-
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- HY-N3199
-
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Bacterial
|
Infection
|
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Neorauflavene is a phenolic neorautanenia isoflavanoid isolated from Neorautanenia edulis. Neorauflavene shows antibacterial activities against E. faecalis, S. suis, S. agalactiae, P. aeruginosa, B. subtilis, and R. anatipestifer .
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-
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- HY-123098
-
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Antifolate
Bacterial
DNA/RNA Synthesis
|
Cancer
|
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Tetrahydromethotrexate is a more potent folate antagonist than Methotrexate (HY-14519) in studies against certain bacteria (Streptococcus faecalis, Pediococcus erevisiae) and in animal models. Tetrahydromethotrexate is used in the research of cancer and autoimmune diseases .
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-
-
- HY-P5695
-
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Bacterial
|
Infection
|
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GP-2B is an antimicrobial peptide. GP-2B shows antibacterial activity against Gram-positive strain (MIC: 8-128 μg/mL for S. aureus and Enterococcus faecalis) .
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-
- HY-113687
-
|
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Bacterial
|
Infection
|
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T145 is an oxazolidinone with antibacterial activity that inhibits growth of gram negatives (K. pneumoniae, A. baumannii, P. aeruginosa and E. cloacae), gram positives (E. faecalis and S. aureus) and acid fast pathogens (Mab, Mav and Mtb) .
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- HY-N14420
-
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Antibiotic
Bacterial
|
Infection
|
|
Parvodicin B2 is a glycopeptide antibiotic. Parvodicin B2 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis. Parvodicin B2 acts by inhibiting the synthesis of bacterial cell wall .
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- HY-N14899
-
|
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Bacterial
|
Infection
|
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Oxasetin has medium activity against Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis (MIC is 16 μg/mL). Oxasetin has no activity against Gram-negative bacteria and fungi .
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- HY-N14418
-
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Antibiotic
Bacterial
|
Infection
|
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Parvodicin B1 is a glycopeptide antibiotic. Parvodicin B1 has inhibitory effect on Staphylococcus aureus, Staphylococcus furfur, Staphylococcus hemolyticus and Enterococcus faecalis. Parvodicin B1 acts by inhibiting the synthesis of bacterial cell wall .
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-
- HY-19289
-
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RWJ 54428
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Bacterial
|
Infection
|
|
MC-02479 is a novel cephalosporin. RWJ-54428 has good activity against most of the organisms tested, including methicillin-resistant staphylococci, E. faecalis, and penicillin-resistant pneumococci, and has moderate activity against E. faecium .
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- HY-176750
-
|
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Bacterial
|
Infection
|
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HMRZ-62 is an antibacterial agent. HMRZ-62 exhibits antibacterial activity against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA) and Vancomycin (HY-B0671)-resistant Enterococcus faecalis (VRE) .
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- HY-N7505
-
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Bacterial
|
Infection
|
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Norchelerythrine is an alkaloid isolated from the roots of Zanthoxylum capense with antibacterial activity against gram-positive and gram-negative bacteria. Norchelerythrine exhibits inhibitory activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis and Escherichia coli with MIC values >50 µg/mL .
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- HY-P5690
-
|
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Bacterial
|
Infection
|
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Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .
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-
- HY-169105
-
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DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-12 (Compound 6d) is a DNA gyrase inhibitor. DNA Gyrase-IN-12 has Antibacterial activity and MIC value of vancomycin-intermediate S. aureus (VISA) and Enterococcus faecalis strains is between 0.031 and 0.0625 μg/mL .
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-
- HY-147958
-
|
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Bacterial
|
Infection
|
|
Antibacterial agent 113 (compound 3) is a potent antibacterial agent. Antibacterial agent 113 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values all of 156.25 μM .
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- HY-N7188
-
|
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Bacterial
|
Infection
|
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CJ-21,058 is a potent SecA inhibitor with an IC50 value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria .
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- HY-161922
-
|
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Bacterial
|
Infection
|
|
Antibacterial agent 235 (compound thy2I) shows antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.5 μg/mL to 8 μg/mL. Antibacterial agent 235 could kill both gram-positive and gram-negative bacteria via a membrane-targeting mechanism of action with a low frequency of resistance .
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-
- HY-161263
-
|
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Bacterial
|
Infection
|
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Antibacterial agent 182 (compound 8c) is an antibacterial agent that shows antibacterial activity against various Gram-positive bacteria, particularly against Vancomycin-resistant Enterococcus faecalis (MIC ≤0.125 μg/mL). Antibacterial agent 182 inhibits biofilm formation of Staphylococcus aureus and Pseudomonas aeruginosa at sub-MIC doses .
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-
- HY-147959
-
|
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Bacterial
|
Infection
|
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Antibacterial agent 114 (compound 1) is a potent antibacterial agent. Antibacterial agent 114 shows antibacterial activity against P.aeruginosa, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, S.mutans, and S.aureus microorganisms, with MIC values of 625, 625, 625, 625, 625, 1250 and 1250 μM, respectively .
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- HY-147957
-
|
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Bacterial
|
Infection
|
|
Antibacterial agent 112 (compound 2) is a potent antibacterial agent. Antibacterial agent 112 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values of 625, 625, 1250, 1250, 1250, 1250 and 1250 μM, respectively .
|
-
- HY-155127
-
|
|
Fungal
|
Cancer
|
|
Antiproliferative agent-33 (Compound 2g) is an anti-proliferative, antifungal, and antibacterial agent. Antiproliferative agent-33 inhibits MDA-MB-231 cell proliferation (IC50: 16.38 μM). Antiproliferative agent-33 inhibits gram-negative bacteria growth, and inhibits S. faecalis with an MIC value of 8 μg/mL .
|
-
- HY-N1654
-
|
|
Bacterial
|
Infection
|
|
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
|
-
- HY-P5697
-
|
|
Bacterial
|
Infection
|
|
Tilapia piscidin 3 is an antimicrobial peptide with antibacterial activity against gram-positive and -negative bacteria (MIC: 2.44, 2.44, 9.78, 19.55, 0.61 μg/mL for V. vulnificus 204, V. alginolyticus, S. agalactiae 819, E. faecalis BCRC 10066, S. agalactiae BCRC 10787). Tilapia piscidin 3 has hemolytic activity in fish red blood cells .
|
-
- HY-178056
-
|
|
Carbonic Anhydrase
Bacterial
|
Infection
|
|
Carbonic anhydrase-IN-2 is an orally active carbonic anhydrase inhibitor. Carbonic anhydrase-IN-2 shows antibacterial effect against various vancomycin-resistant Enterococcus (VRE) strains. Carbonic anhydrase-IN-2 can be used for the research of infection, such as E. faecium .
|
-
- HY-N6846
-
|
|
Bacterial
|
Infection
|
|
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .
|
-
- HY-N0129R
-
|
|
Reference Standards
Bacterial
|
Infection
|
|
Sclareolide (Standard) is the analytical standard of Sclareolide. This product is intended for research and analytical applications. Sclareolide is isolated from the flower of Perilla frutescens with antibacterial and cytotoxic activities[1].
|
-
- HY-125388
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Martinomycin is an antibiotic, which inhibits Staphylococcus spp., Streptococcus spp. and Enterococcus spp., with MICs ranging from 0.06 to 0.5 μg/mL .
|
-
- HY-172962
-
|
|
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
DNA Gyrase-IN-17 (Compound 5C) is a DNA Gyrase inhibitor. DNA Gyrase-IN-17 exhibits significant antibacterial activity against a variety of Gram-positive and Gram-negative strains (such as Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, etc.), with a MIC value of 62.5 μg/mL. DNA Gyrase-IN-17 interferes with DNA replication by inhibiting bacterial DNA gyrase. DNA Gyrase-IN-17 can be used in the development of antibacterial drugs, especially for the study of drug-resistant strains .
|
-
- HY-100126R
-
|
7-Deazaadenosine (Standard)
|
Reference Standards
Bacterial
DNA/RNA Synthesis
Influenza Virus
Antibiotic
|
Infection
|
|
Tubercidin (Standard) is the analytical standard of Tubercidin. This product is intended for research and analytical applications. Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].
|
-
- HY-W781265
-
|
L-755,805
|
Endothelin Receptor
Bacterial
|
Infection
|
|
BE 24566B is a polyketide fungal metabolite originally isolated from S. violaceusniger. It is active against B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus (MICs=1.56, 1.56, 1.56, 1.56, 3.13, and 3.13 μg/mL, respectively). BE 24566B is an endothelin (ET) receptor antagonist (IC50s=11 and 3.9 μM for ETA and ETB receptors, respectively).
|
-
- HY-N0656AR
-
|
|
Reference Standards
mTOR
Bacterial
Autophagy
|
Cancer
|
|
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
- HY-173192
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 272 (Compound Z22) is a potential antimicrobial agent targeting DNA and the DNA-topoisomerase II (DNA-Topo II) complex, exhibiting MIC values of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853, demonstrating potent antibacterial activity. This compound functions by intercalating with DNA base pairs to disrupt normal bacterial DNA function, making it suitable for research on bacterial infectious diseases .
|
-
- HY-B1256AR
-
|
Kefurox (Standard)
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
Cancer
|
|
Cefuroxime (Standard) is the analytical standard of Cefuroxime. This product is intended for research and analytical applications. Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-N16665
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene (Compound 6) is a diterpenoid found in Premna obtusifolia with antibacterial activity. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can significantly inhibit the release of the inflammatory mediator NO, with an IC50 value of 29.1 μM. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can be used for the researches of infection and inflammation .
|
-
- HY-B1256R
-
|
|
Beta-lactamase
Reference Standards
Bacterial
Antibiotic
|
Infection
|
|
Cefuroxime (sodium) (Standard) is the analytical standard of Cefuroxime (sodium). This product is intended for research and analytical applications. Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .
|
-
- HY-E70939
-
|
|
Amino Acid Decarboxylase
|
Metabolic Disease
|
|
L-Phenylalanine decarboxylase, Streptococcus faecalis (EC 4.1.1.53) belongs to the lyase family and is capable of cleaving carbon-carbon bonds. L-Phenylalanine decarboxylase, Streptococcus faecalis is involved in the metabolism of phenylalanine. This enzyme has one substrate, L-phenylalanine, and two products: phenylethylamine and CO2.
|
-
- HY-E71010
-
-
- HY-P2994B
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyrate Dehydrogenase, Alcaligenes faecalis (EC 1.1.1.30) catalyzes the oxidation of 3-hydroxybutyrate to acetoacetate, the first step in the conversion of ketone bodies to citric acid, which is then further metabolized via the tricarboxylic acid cycle (Krebs cycle).
|
-
- HY-P2825A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Tyrosine Decarboxylase, Streptococcus faecalis (EC 4.1.1.25), is a carboxyl lyase capable of cleaving carbon-carbon bonds. L-Tyrosine Decarboxylase Apoenzyme participates in tyrosine metabolism and alkaloid biosynthesis. L-Tyrosine Decarboxylase Apoenzyme uses a cofactor—pyridoxal phosphate. L-Tyrosine Decarboxylase Apoenzyme has one substrate, L-tyrosine, and two products: tyramine and carbon dioxide.
|
-
- HY-E70938
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Tyrosine Decarboxylase Apoenzyme, Streptococcus faecalis (EC 4.1.1.25), is a carboxyl lyase capable of cleaving carbon-carbon bonds. L-Tyrosine Decarboxylase Apoenzyme participates in tyrosine metabolism and alkaloid biosynthesis. L-Tyrosine Decarboxylase Apoenzyme uses a cofactor—pyridoxal phosphate. L-Tyrosine Decarboxylase Apoenzyme has one substrate, L-tyrosine, and two products: tyramine and carbon dioxide.
|
-
- HY-10391
-
|
|
Bacterial
|
Infection
|
|
E3709 is an antibacterial agent. E3709 exhibits significant inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA), Enterococcus faecalis, streptococci, Clostridia, and diphtheroids. E3709 can be used for research related to Gram-positive bacterial infections .
|
-
- HY-124886
-
|
N-Phenylacetylphenylalanine
|
Amino Acid Derivatives
|
Others
|
|
N-(Phenylacetyl)-L-phenylalanine (N-Phenylacetylphenylalanine) is an amino acid analog. N-(Phenylacetyl)-L-phenylalanine is produced via the enantioselective acylation of L-phenylalanine catalyzed by penicillin G acylase from Alcaligenes faecalis. N-(Phenylacetyl)-L-phenylalanine undergoes hydrolysis in aqueous media .
|
-
- HY-181686
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 326 is a bactericide that inhibits the growth of various bacterial strains. Antibacterial agent 326 inhibits biofilm formation in Escherichia coli, disrupts bacterial cell membranes, induces oxidative stress and lipid peroxidation in Escherichia coli, increases ROS levels, and reduces GSH activity. Antibacterial agent 326 can be used in studies of bacterial infections, including those caused by Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Listeria spp., Bacillus subtilis, Serratia marcescens, Salmonella enteritidis and Acinetobacter calcoaceticus .
|
-
- HY-N14392
-
|
|
Bacterial
|
Infection
|
|
Fluoropolyoxin M has the inhibitory activity of Escherichia coli and Streptococcus faecalis .
|
-
- HY-W039699
-
|
2-(4-Methylphenyl)propionic acid
|
COX
Bacterial
Drug Intermediate
|
Infection
|
|
2-(p-Tolyl) propanoic acid (2-(4-methylphenyl) propionic acid) acts as an Antimicrobial agent intermediate. 2-(p-Tolyl) propanoic acid inhibits COX-1 and COX-2 enzymes, with IC50 values of 38.23 μM and 64.30 μM, respectively. 2-(p-Tolyl) propanoic acid is applicable to research on E. coli, Enterococcus faecalis, Listeria monocytogenes, and Staphylococcus aureus .
|
-
- HY-N5196
-
|
Nocathiacine I
|
Bacterial
|
Infection
|
|
Nocathiacin I (Nocathiacine I) is highly resistant to Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP) and multidrug resistant Enterococcus faecalis (MREF) .
|
-
- HY-182798
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 337 is an antibacterial agent. Antibacterial agent 337 specifically interacts with PG in bacterial cell membranes, triggering membrane disruption, membrane depolarization, increased permeability, cytoplasmic leakage, ROS accumulation and rapid bacterial death. Antibacterial agent 337 inhibits biofilm formation and disrupts mature biofilms. Antibacterial agent 337 exhibits potent in vivo antibacterial efficacy in a mouse model of Staphylococcus aureus skin abscess. Antibacterial agent 337 can be used in studies of Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus infections, vancomycin-resistant Enterococcus faecalis infections and bacterial biofilm infections .
|
-
- HY-112027
-
|
Ciprofloxacin impurity E
|
Bacterial
|
Infection
|
|
Decarboxy ciprofloxacin (Decarboxylated ciprofloxacin) is an antibacterial agent. Decarboxy ciprofloxacin displays antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus subtilis, Enterobacter cloacae, Serratia marcescens and especially potent activity against Escherichia coli .
|
-
- HY-N12229
-
|
|
Endogenous Metabolite
Bacterial
|
Infection
|
|
Penipurdin A (Compound 1), an anthraquinone, is a microbial secondary metabolite. Penipurdin A can be isolated from the soil fungus Penicillium purpurogenum SC0070. Penipurdin A has no significant cytotoxicity against cancer cells, such as A549, HepG2 and Hela cells. Penipurdin A has antibacterial activity against Enterococcus faecalis and Staphylococcus aureus .
|
-
- HY-N8316
-
|
|
Others
|
Infection
|
|
Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/mL, respectively.1 Rugulotrosin A is inactive against Gram-negative bacteria.
|
-
- HY-108939R
-
|
IleSA (Standard)
|
Reference Standards
Bacterial
Aminoacyl-tRNA Synthetase
|
Infection
|
|
Aminoacyl tRNA synthetase-IN-1 (Standard) is the analytical standard of Aminoacyl tRNA synthetase-IN-1 (HY-108939). This product is intended for research and analytical applications. Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-1 has inhibitory activity against S. aureus, E. faecalis and E.coli .
|
-
- HY-172390
-
|
|
Bacterial
|
Infection
|
|
Florfenicol-propanoate-piperidin (Compound 1) is the derivative of Florfenicol (HY-B1374). Florfenicol-propanoate-piperidin exhibits antibacterial activity, inhibits E. coli ATCC25922, Salmonella CICC110420, S. aureus ATCC29213, B. subtilis CMCC(B)63501, E. faecalis ATCC29212, S. suis CVCC606, and Haemophilus parasuis with MIC of 2-8 μM .
|
-
- HY-183291
-
|
|
Bacterial
DNA/RNA Synthesis
DNA Alkylator/Crosslinker
Reactive Oxygen Species (ROS)
Penicillin-binding protein (PBP)
|
Infection
|
|
Antibacterial agent 343 (Compound 47) is an Antibacterial agent. Antibacterial agent 343 binds to the allosteric site of PBP2a to open its active site. Antibacterial agent 343 disrupts bacterial cell membranes, leading to protein leakage. Antibacterial agent 343 interacts with DNA and inhibits replication and transcription. Antibacterial agent 343 induces ROS accumulation. Antibacterial agent 343 exhibits antibacterial activity against MRSA, Staphylococcus aureus, and Enterococcus faecalis. Antibacterial agent 343 can be used for the research of methicillin-resistant Staphylococcus aureus infections .
|
-
- HY-182022
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
Drug Derivative
DNA/RNA Synthesis
|
Infection
|
|
ZLWH-67 is a β-Carboline derivative and Antibacterial agent. ZLWH-67 inhibits DNA synthesis, suppresses biofilm formation, and increases reactive oxygen species (ROS) levels. ZLWH-67 exhibits potent in vitro antibacterial activity against MRSA (MIC = 0.5-4 μg/mL), S. epidermidis (MIC = 4 μg/mL), E. faecalis (MIC = 4-8 μg/mL), and S. pneumoniae (MIC = 16 μg/mL). ZLWH-67 displays anti-MRSA effects in murine skin and pneumonia infection models .
|
-
- HY-111034
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
CGP 31523A is a broad-spectrum aminothiazole cephalosporin. CGP 31523A exhibits potent inhibitory effects on Enterobacteriaceae, Neisseria, Haemophilus influenzae, and Streptococcus (except Enterococcus faecalis), among others. CGP 31523A can be hydrolyzed by the common Escherichia coli type Ic β-lactamase, but is stable against the Ia type enzyme. CGP 31523A is neither an effective β-lactamase inhibitor nor does it induce the production of β-lactamase. CGP 31523A can be used for studying infections caused by Gram-negative bacteria (including drug-resistant strains) .
|
-
- HY-146470
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 103 (compound 7) has highly antibacterial activity against kinds of Gram-positive and -negative bacteria. Antibacterial agent 103 can be used for researching inhibition of resistance bacterial strains .
|
-
- HY-108939
-
|
IleSA
|
Bacterial
Aminoacyl-tRNA Synthetase
|
Infection
|
|
Aminoacyl tRNA synthetase-IN-1 (IleSA) is an inhibitor of bacterial aminoacyl-tRNA synthetase (aaRS). Aminoacyl tRNA synthetase-IN-1 is applicable to studies on bacterial infections .
|
-
- HY-168729
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I). Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model .
|
-
- HY-151458
-
|
|
VEGFR
Bacterial
Dihydrofolate reductase (DHFR)
Fungal
|
Infection
Cancer
|
|
VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer .
|
-
- HY-178952
-
|
|
Bacterial
|
Infection
|
|
Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC50 of 4.475 μM and a Kd of 16.3 μM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 μg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 μg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models .
|
-
- HY-181075
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 318 is an antibacterial agent that binds to bacterial DNA, blocks its replication, and forms supramolecular complexes. Antibacterial agent 318 acts as an oxidative stress inducer, elevating intracellular reactive oxygen species (ROS) levels, oxidizing glutathione (GSH) to glutathione disulfide (GSSG), depleting cellular GSH reserves, and inducing bacterial cell death through oxidative damage. Antibacterial agent 318 disrupts the bacterial cell membrane and reduces bacterial metabolic activity. Antibacterial agent 318 exhibits rapid bactericidal activity, inhibits bacterial biofilm formation, and displays minimal cytotoxicity toward non-cancerous mammalian cells. Antibacterial agent 318 is applicable in research on drug-resistant bacterial infections .
|
-
- HY-180767
-
|
|
Drug Derivative
Bacterial
Topoisomerase
|
Infection
Cancer
|
|
Azithromycin-amide-C3-amide-quinoxaline (Compound 5f) is an Azithromycin (HY-17506) derivative and antibacterial agent. Azithromycin-amide-C3-amide-quinoxaline inhibits topoisoisomerase I with an IC50 of 120.7 μM. Azithromycin-amide-C3-amide-quinoxaline interacts with 70S E. coli ribosome with a Kd of 0.8 nM. Azithromycin-amide-C3-amide-quinoxaline inhibits bacterial translation with an IC50 of 0.7 μM. Azithromycin-amide-C3-amide-quinoxaline shows antibacterial potency against S. pneumonia ATCC 49619, S. aureus ATCC 29213, E. faecalis ATCC 29212 with MICs of 0.06 μg/mL, 2 μg/mL, 0.5 μg/mL, respectively. Azithromycin-amide-C3-amide-quinoxaline exhibits anticancer activity against prostate cancer, colon cancer .
|
-
- HY-N15140
-
|
|
Drug Isomer
Bacterial
Fungal
Carboxypeptidase
|
Infection
Cancer
|
|
α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .
|
-
- HY-W012346
-
|
|
Drug Derivative
Bacterial
|
Infection
|
|
Geranyl isobutyrate is a synthetic α,β‑unsaturated branched‑chain aliphatic ester and a geraniol derivative. Geranyl isobutyrate acts as a food and feed flavouring agent and a biologically active antimicrobial compound. Geranyl isobutyrate shows antimicrobial activity against Gram‑positive and most Gram‑negative bacteria .
|
-
- HY-W154247
-
|
|
Bacterial
|
Infection
|
IP6C is a specific inhibitor and phage sensitizer targeting type II Thoeris systems. IP6C competitively binds to histidine in the catalytic pocket of ThsB, blocks the production of the His-ADPR alarm signal and inhibits ThsA activation, thereby relieving bacterial stasis of phage replication. IP6C selectively resensitizes drug-resistant bacteria carrying type II Thoeris systems (such as Pseudomonas aeruginosa) to phage lysis, without affecting other bacteria, and shows no toxicity to mice and human cell lines. IP6C significantly improves the survival rate of infected mice, and can be used to overcome bacterial phage defense mechanisms and study Pseudomonas aeruginosa infections .
Thoeris system: (named after the Egyptian goddess of fertility and protection), is a widespread anti-phage immune defense system in bacteria and archaea. Thoeris system belongs to the "Abortion Infection (Abi)" mechanism of bacteria: when an individual bacterium detects phage invasion, it initiates a suicide program and dies, thereby blocking phage replication and spread, and protecting the surrounding bacterial population from infection.
|
-
- HY-116558
-
|
|
Bacterial
|
Infection
|
|
E-4441 is an orally active Antibacterial agent. E-4441 exerts broad-spectrum in vitro antibacterial activity against Gram-positive bacteria and aerobic bacteria. E-4441 exhibits protective effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections. E-4441 can be used in the research of systemic bacterial infections (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections) .
|
-
- HY-181264
-
|
|
|
Infection
|
|
Antifungal agent 153, a derivative of Blasticidin S (HY-103401A), is an antibacterial agent. Antifungal agent 153 retains the antibacterial activity of Blasticidin S, exhibits potent inhibitory effects against multidrug-resistant Gram-positive bacteria, and significantly reduces mammalian cytotoxicity. Antifungal agent 153 can be used in studies related to bacterial infections .
|
-
- HY-P11659
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
B26 peptoid is a ptoid antibiotic. B26 peptoid exhibits excellent broad-spectrum activity and high selectivity toward a panel of Gram-positive and Gram-negative bacterial strains. B26 peptoid disrupts bacterial membranes and has bactericidal activity. B26 peptoid shows low propensity for bacterial drug resistance. B26 peptoid can be used for the research of bacterial infection .
|
-
- HY-165460
-
|
|
Antibiotic
Beta-lactamase
Bacterial
Penicillin-binding protein (PBP)
|
Infection
|
|
AM-112 is a β-lactamase (β-lactamase) inhibitor and antibacterial agent, with IC50 values ranging from 0.0002 μg/mL to 0.67 μg/mL against class A, C, and D β-lactamase. By inhibiting PBP2, the penicillin-binding protein of E. coli, and protecting Ceftazidime (HY-B0593) from enzymatic hydrolysis, AM-112 significantly enhances the antibacterial efficacy of Ceftazidime against Gram-negative bacteria, enterococci, and staphylococci. AM-112 exhibits favorable pharmacokinetic properties and acid-base stability. AM-112 can be used for the research of bacterial infections .
|
-
- HY-126387
-
|
|
Bacterial
Antibiotic
Penicillin-binding protein (PBP)
|
Infection
|
|
Moenomycin complex is a class of antibacterial agents and PBP inhibitors, with Kd values ranging from 94 nM to 1690 nM against various bacterial PBPs. Moenomycin complex inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs). Moenomycin complex is used in the research of bacterial infections .
|
-
- HY-B0771
-
|
SCE-2787
|
Antibiotic
Bacterial
Penicillin-binding protein (PBP)
|
Infection
|
|
Cefozopran (SCE-2787) is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran can be used for the research of bacterial infections .
|
-
- HY-W740077
-
|
SCE-2787 dihydrochloride
|
Antibiotic
Bacterial
Penicillin-binding protein (PBP)
|
Infection
|
|
Cefozopran (SCE-2787) dihydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran dihydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran dihydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran dihydrochloride can be used for the research of bacterial infections .
|
-
- HY-B0771A
-
|
SCE-2787 hydrochloride
|
Antibiotic
Bacterial
Penicillin-binding protein (PBP)
|
Infection
|
|
Cefozopran (SCE-2787) hydrochloride is a potent antibiotic with broad-spectrum antibacterial activity. Cefozopran hydrochloride binds PBPs, induces cell wall destruction, cell elongation, filamentation, irregular septa formation, and bactericidal, bacteriolytic activity. Cefozopran hydrochloride reduces bacterial counts and eradicates bacteria in mouse respiratory, urinary, and thigh muscle infections. Cefozopran hydrochloride can be used for the research of bacterial infections .
|
-
- HY-180125
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 307 is an antibacterial agent. Antibacterial agent 307 shows MICs of 1-4 μg/mL against Gram-positive bacteria, moderate activity against Gram-negative bacteria, low hemolytic toxicity, and excellent plasma stability. Antibacterial agent 307 compromises bacterial membrane integrity via increased permeability and depolarization, induces endogenous ROS accumulation, causes cytoplasmic protein and nucleic acid leakage, and drives rapid bacterial cell death. Antibacterial agent 307 can be used for the research of bacterial infection .
|
-
- HY-124617
-
AMXT-1501
Maximum Cited Publications
10 Publications Verification
|
Apoptosis
Bacterial
|
Infection
Cancer
|
|
AMXT-1501 is a Bacterial agent and polyamine transport system inhibitor. AMXT-1501 targets membrane phospholipids and exhibits antibacterial activity against a variety of Gram-positive and Gram-negative multidrug-resistant bacteria . AMXT-1501 inhibits capsular biosynthesis in Streptococcus pneumoniae . AMXT-1501 targets ornithine decarboxylase and polyamines to inhibit the proliferation of neuroblastoma cells . AMXT-1501 in combination with DFMO (HY-B0744) induces Apoptosis in neuroblastoma cells. AMXT-1501 is applicable to research related to multidrug-resistant bacterial infections, pneumococcal infections, Streptococcus pneumoniae infections, and neuroblastoma .
|
-
- HY-N19290
-
|
|
Bacterial
|
Infection
|
|
Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections .
|
-
- HY-182027
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
Lactate Dehydrogenase
DNA/RNA Synthesis
|
Infection
|
Antibacterial agent 330 is an antibacterial agent. Antibacterial agent 330 triggers ROS accumulation, forms DNA supramolecular complex by intercalation to block DNA replication and inhibits LDH to
disturb metabolism, and further prompts bacterial cell rupture to induce the leakage of intracellular content, ultimately causing bacterial death. Antibacterial agent 330 displays antibacterial activity and promotes wound healing in both G. Mellonella larval and murine wound infection models. Antibacterial agent 330 can be used for the research of bacterial infections .
|
-
- HY-182056
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 331 is an antibacterial agent with anti-biofilm activity. Antibacterial agent 331 exhibits activity against a variety of Gram-positive and Gram-negative bacteria. Antibacterial agent 331 eliminates MRSE 62 and promotes the repair of infected wounds in mouse models. Antibacterial agent 331 can be used for research on infections .
|
-
- HY-P11583
-
|
|
Bacterial
|
Infection
|
|
N2W2 is a tryptophan- and lysine-rich β-hairpin antimicrobial peptide. N2W2 exhibits potent antimicrobial activity but also high toxicity. N2W2 is highly susceptible to trypsin or chymotrypsin. N2W2 can be used for the research of bacterial infection .
|
-
- HY-105213
-
|
MC-352
|
Antibiotic
Bacterial
|
Infection
|
|
YM-17K (MC-352) is a macrolide antibiotic. YM-17K exhibits antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and anaerobic bacteria. YM-17K exhibits stable activity in serum and is less affected by pH values .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-N8332
-
|
Ox bile extract
|
Biochemical Assay Reagents
|
|
Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens .
|
-
- HY-125569
-
|
|
Biochemical Assay Reagents
|
|
Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P5203
-
|
EntK1
|
Bacterial
|
Infection
|
|
Enterocin K1 (EntK1) is a bacteriocin. Enterocin K1 is a ribosomal synthetic peptide. Enterocin K1 specifically targets Enterococcus faecalis via the Eep protein on the bacterial membrane. Enterocin K1 displays a potent antibacterial activity against VRE. Enterocin K1 can be used for related studies of VRE infections .
|
-
- HY-P10996
-
|
Human Neutrophil Peptide-4 TFA
|
Bacterial
SARS-CoV
|
Infection
|
|
Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candida albicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients .
|
-
- HY-P5554
-
|
|
Bacterial
|
Infection
|
|
cOB1 phermone, a bacterial sex pheromone, effectively inhibits multidrug-resistant Enterococcus faecalis V583 .
|
-
- HY-P10134
-
|
|
Bacterial
|
Infection
|
|
Salivaricin B is a broad-spectrum bacteriocin produced by Lactobacillus salivarius M7, capable of inhibiting the growth of Listeria monocytogenes, Bacillus cereus, Brochothrix thermosphacta, Enterococcus faecalis, and various lactobacilli .
|
-
- HY-P5695
-
|
|
Bacterial
|
Infection
|
|
GP-2B is an antimicrobial peptide. GP-2B shows antibacterial activity against Gram-positive strain (MIC: 8-128 μg/mL for S. aureus and Enterococcus faecalis) .
|
-
- HY-P5690
-
|
|
Bacterial
|
Infection
|
|
Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .
|
-
- HY-P5697
-
|
|
Bacterial
|
Infection
|
|
Tilapia piscidin 3 is an antimicrobial peptide with antibacterial activity against gram-positive and -negative bacteria (MIC: 2.44, 2.44, 9.78, 19.55, 0.61 μg/mL for V. vulnificus 204, V. alginolyticus, S. agalactiae 819, E. faecalis BCRC 10066, S. agalactiae BCRC 10787). Tilapia piscidin 3 has hemolytic activity in fish red blood cells .
|
-
- HY-P11659
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
B26 peptoid is a ptoid antibiotic. B26 peptoid exhibits excellent broad-spectrum activity and high selectivity toward a panel of Gram-positive and Gram-negative bacterial strains. B26 peptoid disrupts bacterial membranes and has bactericidal activity. B26 peptoid shows low propensity for bacterial drug resistance. B26 peptoid can be used for the research of bacterial infection .
|
-
- HY-P11583
-
|
|
Bacterial
|
Infection
|
|
N2W2 is a tryptophan- and lysine-rich β-hairpin antimicrobial peptide. N2W2 exhibits potent antimicrobial activity but also high toxicity. N2W2 is highly susceptible to trypsin or chymotrypsin. N2W2 can be used for the research of bacterial infection .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-100126
-
-
-
- HY-N0656A
-
|
|
other families
Classification of Application Fields
Ketones, Aldehydes, Acids
Plants
Lichen
Disease Research Fields
Cancer
|
mTOR
Bacterial
Autophagy
|
|
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
-
- HY-N10264
-
|
(+)-Avrainvillamide; CJ-17,665
|
Infection
Alkaloids
Microorganisms
Pyrrole Alkaloids
Classification of Application Fields
Disease Research Fields
Indole Alkaloids
Source Classification
|
Antibiotic
|
|
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively .
|
-
-
- HY-N5009
-
-
-
- HY-125733
-
-
-
- HY-N13668
-
|
|
Structural Classification
Phenols
Polyphenols
Myrtaceae
Rhodomyrtus tomentosa
Plants
Source Classification
|
Antibiotic
Bacterial
|
|
Rhodomyrtone is an antibiotic that can be found in the leaves of Rhodomyrtus tomentosa. Rhodomyrtone kills Gram-positive bacterial cells without causing bacteriolysis. Rhodomyrtone exhibits activity against a variety of Gram-positive bacteria, including Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus salivarius. Rhodomyrtone is applicable to studies related to bacterial infections .
|
-
-
- HY-129434A
-
-
-
- HY-N7652
-
-
-
- HY-N0129
-
-
-
- HY-N0983
-
-
-
- HY-126461
-
-
-
- HY-W923644
-
|
Aegelinol; (-)-Smyrinol
|
Structural Classification
Wyethia glabra A.Gray
Coumarins
Phenylpropanoids
Umbelliferae
Plants
Source Classification
|
Bacterial
|
|
(-)-Decursinol (Aegelinol; (-)-Smyrinol) is a natural pyranocoumarin compound tant can be isolated from the roots of Apiaceae plants such as Ferulago campestris. (-)-Decursinol inhibits both Gram-positive bacteria (Staphylococcus aureus ATCC 13709, Enterococcus faecalis ATCC 14428) and Gram-negative bacteria (Salmonella typhii ATCC 19430, Enterobacter cloacae ATCC 10699, Enterobacter aerogenes ATCC 13048) with minimum inhibitory concentrations (MIC) ranging from 16 to 64 μg/mL. (-)-Decursinol possesses antioxidant activity. (-)-Decursinol can be used for the study of bacterial infections .
|
-
-
- HY-125569
-
-
-
- HY-N10561
-
|
|
Microorganisms
Antibiotics
Antibacterial
Disease Research
|
Bacterial
|
|
Wychimicin A is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin A shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
|
-
-
- HY-N10560
-
|
|
Microorganisms
Antibiotics
Antibacterial
Disease Research
|
Bacterial
|
|
Wychimicin C is a spirotetronate polyketide, can be isolated from the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicin C shows strong antibacterial activity against methicillin-resistant Staphylococcus. aureus (IC50=0.125-0.5 μg/mL) and Enterococcus. faecalis/faecium (IC50=0.125-0.25 μg/mL) .
|
-
-
- HY-N9477
-
-
-
- HY-130596
-
-
-
- HY-N14367
-
-
-
- HY-N14416
-
-
-
- HY-N5181
-
-
-
- HY-N15040
-
-
-
- HY-N5195
-
-
-
- HY-N5184
-
-
-
- HY-N3199
-
-
-
- HY-P5695
-
-
-
- HY-N14420
-
-
-
- HY-N14899
-
-
-
- HY-N14418
-
-
-
- HY-N7505
-
-
-
- HY-N7188
-
|
|
Natural Products
Microorganisms
Source Classification
|
Bacterial
|
|
CJ-21,058 is a potent SecA inhibitor with an IC50 value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria .
|
-
-
- HY-N1654
-
|
|
Infection
Natural Products
Classification of Application Fields
Azadirachta indica A. Juss.
Plants
Meliaceae
Disease Research Fields
Source Classification
|
Bacterial
|
|
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .
|
-
-
- HY-N6846
-
|
|
Infection
Natural Products
Classification of Application Fields
Inula helenium L.
Plants
Compositae
Disease Research Fields
Source Classification
|
Bacterial
|
|
10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures. 10-Isobutyryloxy-8,9-epoxythymol isobutyrate shows moderate antimicrobial activity against Staphylococcus aureus FDA 209 P, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Pseudomonas aeruginosa with MICs of 50, 250, 250, 250, and 1000 μg/mL, respectively .
|
-
-
- HY-N0129R
-
-
-
- HY-125388
-
-
-
- HY-100126R
-
-
-
- HY-N0656AR
-
|
|
Structural Classification
other families
Ketones, Aldehydes, Acids
Plants
Lichen
|
Reference Standards
mTOR
Bacterial
Autophagy
|
|
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
-
- HY-N16665
-
|
|
Structural Classification
Premna IntegrifoliaL.
Terpenoids
Verbenaceae
Diterpenoids
Plants
Source Classification
|
Bacterial
|
|
6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene (Compound 6) is a diterpenoid found in Premna obtusifolia with antibacterial activity. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can significantly inhibit the release of the inflammatory mediator NO, with an IC50 value of 29.1 μM. 6α,11,12-Trihydroxy-7β,20-epoxy-8,11,13-abietatriene can be used for the researches of infection and inflammation .
|
-
-
- HY-N14392
-
-
-
- HY-N5196
-
-
-
- HY-N12229
-
|
|
Quinones
Microorganisms
Anthraquinones
Source Classification
|
Endogenous Metabolite
Bacterial
|
|
Penipurdin A (Compound 1), an anthraquinone, is a microbial secondary metabolite. Penipurdin A can be isolated from the soil fungus Penicillium purpurogenum SC0070. Penipurdin A has no significant cytotoxicity against cancer cells, such as A549, HepG2 and Hela cells. Penipurdin A has antibacterial activity against Enterococcus faecalis and Staphylococcus aureus .
|
-
-
- HY-N8316
-
-
-
- HY-N15140
-
|
|
Structural Classification
Natural Products
Cupressaceae
Ketones, Aldehydes, Acids
Plants
Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc.
Source Classification
|
Drug Isomer
Bacterial
Fungal
Carboxypeptidase
|
|
α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC50: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .
|
-
-
- HY-W012346
-
-
-
- HY-N19290
-
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-120397
-
|
|
|
PROTAC Synthesis
Alkynes
|
|
Bis-propargyl-PEG4 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG4 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-133191
-
|
|
|
PROTAC Synthesis
Alkynes
|
|
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
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