Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
genomic nucleic acids
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "genomic nucleic acids" in MCE Product Catalog:
Cat. No.: HY-W440911
Target:
Research Areas:
DSPE-PEG2000-Cy5 is a Cy5 (HY-D0821) fluorophore-labeled conjugate of distearoylphosphatidylethanolamine and polyethylene glycol, as well as a liposome component. The Cy5 fluorophore is commonly used for labeling proteins and nucleic acids in imaging, flow cytometry and genomic applications. DSPE-PEG2000-Cy5 supports cell membrane modification, in vivo tumor targeting research and long-term in vivo circulation of its liposomal formulations (Ex/Em=633/670 nm) .
Cat. No.: HY-D3416
Synonyms: TAMRA-2,4-dinitroaniline
Target:
Research Areas:
TMR-DN (TAMRA-2,4-dinitroaniline) is a fluorescent probe for RNA imaging that consists of a covalently coupled fluorophore (5-carboxy tetramethylrhodamine (TMR)) and quencher (dinitroaniline (DN)). The Kd value of TMR-DN with SRB-2 is 35 nM, and its Kd value with RhoBAST is approximately 30 nM. TMR-DN has a contact quenching function and forms a non-fluorescent intramolecular ground-state dimer in the free state; the excitation/emission wavelengths of the free probe are Ex/Em = 557/579 nm, those of the complex formed by binding to SRB-2 are Ex/Em = 561/587 nm, and those of the probe bound to the DNB aptamer are Ex/Em = 555/582 nm. TMR-DN reduces non-specific binding to genomic nucleic acids via negatively charged carboxyl-functionalized aromatic rings. Fluorescence dequenching occurs when TMR-DN specifically binds to SRB-2, RhoBAST or the DNB aptamer, among which the binding of RhoBAST requires Mg 2+ for proper folding .
Cat. No.: HY-W1061847
Research Areas:
5-VIC Phosphoramidite is a Fluorescent dye and a component of TaqMan probes for nucleic acid detection. 5-VIC Phosphoramidite serves as a 5' reporter dye, which is conjugated to probes targeting the conserved region of the S protein of porcine epidemic diarrhea virus genotype GII, and is used with Eclipse® Dark Quencher for duplex real-time quantitative PCR. 5-VIC Phosphoramidite-labeled probes targeting the Rv0222 gene in the RD4 region specific to Mycobacterium tuberculosis are applied in triplex droplet digital PCR to differentiate mycobacterial strains. During PCR amplification, the 5'→3' exonuclease activity of Taq polymerase mediates the separation of 5-VIC Phosphoramidite from the quencher, thereby generating a detectable fluorescent signal .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
