Halogenated Fatty Acids

2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis.

Sodium dichloroacetate is an orally active pyruvate dehydrogenase kinase (PDK) inhibitor. Sodium dichloroacetate also stimulates pyruvate dehydrogenase (PDH) activity and works as a Na⁺-K⁺-2Cl⁻ cotransporter (NKCC) inhibitor. Sodium dichloroacetate prevents the phosphorylation of the E1α subunit of PDC, promoting the entry of pyruvate into the mitochondria for oxidative metabolism, reducing lactate production, and simultaneously increasing the production of reactive oxygen species (ROS). Sodium dichloroacetate inhibits tumor cell proliferation and induces apoptosis. Sodium dichloroacetate is promising for research of cancers.

9-Bromononanoic acid is a PROTAC linker. 9-Bromononanoic acid can be used in synthesis PROTAC FGFR1 degrader-1 (HY-170869).

2-Fluoropalmitic acid, an acyl-CoA synthetase inhibitor, acts as a candidate anti-glioma agent. 2-Fluoropalmitic acid suppresses the viability and stem-like phenotype of glioma stem cells (GSCs). 2-Fluoropalmitic acid also inhibits proliferation and invasion of glioma cell lines.

2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3.

11-Bromoundecanoic acid is a PROTAC linker that can be used for the synthesis of PROTACs, such as INY-05-040 (HY-160469).

10-Bromodecanoic acid (Decanoic acid, 10-bromo-) is a linker that can be used in the synthesis of PROTACs, such as PROTAC KDM4 degrader-1 (HY-173135).

12-Bromododecanoic acid is a bromo fatty acid. 12-Bromododecanoic acid can be used in the synthesis of clickable forms of myristic acid. 12-Bromododecanoic acid inhibits HIV replication in CEM-SS T cells (EC₅₀ = 38 µM).

16-Bromohexadecanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

18-Bromooctadecanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

Dibromoacetic acid, a haloacetic acid found in drinking water as a disinfection by-product, can cause many adverse effects, including immunotoxicity and apoptosis.

Diiodoacetic acid is a disinfection by-product (DBP) formed during water disinfection.

2,3,3-Tribromopropenoic acid is a 2,3,3-Tribromo product based on propenoic acid. 2,3,3-Tribromopropenoic acid is a polar aromatic brominated disinfection byproduct during chlorination in water and shows cytotoxic potency in mammalian cell chronic cytotoxicity experiments.

3,3-Dibromopropenoic acid is a 3,3-dibromo product based on propenoic acid. 3,3-Dibromopropenoic acid is a polar aromatic brominated disinfection byproduct during chlorination in water.

9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. 9,10-Dichlorostearic acid can cause membrane damage by inducing leakage of adenosine triphosphate (ATP) from mammalian tumour cells in vitro.

4,7,10,13,16,19-Docosahexaenoyl chloride is an ester derivative formed by Iloperidone (HY-17410) metabolite P-88-8991 and polyunsaturated fatty acid (linoleic acid derivative), which acts as a prodrug of P-88-8991. 4,7,10,13,16,19-Docosahexaenoyl chloride can be used for the research of mental disorders (schizophrenia, bipolar disorder).

Undecanoyl chloride is a fatty acid chloride.

cis-Vaccenoyl chloride is a fatty acid chloride.

(E)-3-Chloroacrylic acid is an intermediate. (E)-3-Chloroacrylic acid can be used in the synthesis of Compound 81. (E)-3-Chloroacrylic acid can be used in research on human non-small cell lung cancer with KRAS G12C mutation. (E)-3-Chloroacrylic acid is a substrate of trans-3-chloroacrylic acid dehalogenase (Km = 34 µM).

2-Chlorooctadecanoic acid (2-Chlorostearic acid) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.