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glucocorticoid steroid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucocorticoid Receptor (64) ADC Payload (5) Androgen Receptor (6) Antibiotic (3) AP-1 (1) Bacterial (3) Biochemical Assay Reagents (1) Cytochrome P450 (1) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (3) Endogenous Metabolite (20) Enterovirus (4) Environmental Pollutants (1) Estrogen Receptor/ERR (1) Interleukin Related (8) Isotope-Labeled Compounds (14) Mineralocorticoid Receptor (1) NF-κB (2) Phosphatase (1) Progesterone Receptor (6) Reference Standards (12) TGF-β Receptor (4)
By Research Areas:	Cancer (22) Cardiovascular Disease (3) Endocrinology (43) Infection (7) Inflammation/Immunology (55) Metabolic Disease (11) Neurological Disease (10)

By Targets:

Glucocorticoid Receptor (64)

ADC Payload (5)

Androgen Receptor (6)

Antibiotic (3)

AP-1 (1)

Bacterial (3)

Biochemical Assay Reagents (1)

Cytochrome P450 (1)

Drug Derivative (1)

Drug Intermediate (1)

Drug Isomer (1)

Drug Metabolite (3)

Endogenous Metabolite (20)

Enterovirus (4)

Environmental Pollutants (1)

Estrogen Receptor/ERR (1)

Interleukin Related (8)

Isotope-Labeled Compounds (14)

Mineralocorticoid Receptor (1)

NF-κB (2)

Phosphatase (1)

Progesterone Receptor (6)

Reference Standards (12)

TGF-β Receptor (4)

By Research Areas:

Cancer (22)

Cardiovascular Disease (3)

Endocrinology (43)

Infection (7)

Inflammation/Immunology (55)

Metabolic Disease (11)

Neurological Disease (10)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Targets Recommended: Steroid Sulfatase Glucocorticoid Receptor SGK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0583

Hydrocortisone Maximum Cited Publications 85 Publications Verification Cortisol	Environmental Pollutants Endogenous Metabolite Glucocorticoid Receptor	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-B0469

Medroxyprogesterone acetate 30+ Cited Publications Medroxyprogesterone 17-acetate; Farlutin	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Cancer
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-B1829A

Dexamethasone phosphate disodium 10+ Cited Publications Dexamethasone 21-phosphate disodium	Glucocorticoid Receptor TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

HY-13580

Budesonide 5+ Cited Publications	Glucocorticoid Receptor ADC Payload	Inflammation/Immunology Cancer
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-B1402

Hydrocortisone hemisuccinate 1 Publications Verification Hydrocortisone 21-hemisuccinate	Interleukin Related	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .

HY-14648A

Dexamethasone acetate 5+ Cited Publications Dexamethasone 21-acetate; Hexadecadrol acetate	Glucocorticoid Receptor	Inflammation/Immunology
Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery .

HY-77839

Cortodoxone 4 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-N0583R

Hydrocortisone (Standard) Maximum Cited Publications 85 Publications Verification Cortisol (Standard)	Reference Standards Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone (Standard) is the analytical standard of Hydrocortisone. This product is intended for research and analytical applications. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-N0583S2

Hydrocortisone-d4 Cortisol-d₄	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₄ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-132811

Dazucorilant CORT113176	Glucocorticoid Receptor	Neurological Disease Inflammation/Immunology
Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a K_i value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders .

HY-17358

Loteprednol Etabonate	Glucocorticoid Receptor Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology
Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology .

HY-B0154

Fluticasone propionate 1 Publications Verification	Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (K_D) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-B0485

Fluocinonide	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.

HY-N0583S1

Hydrocortisone-d7 Cortisol-d₇	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₇ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-13580S

Budesonide-d8	Glucocorticoid Receptor	Inflammation/Immunology Cancer
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-13571

Betamethasone dipropionate 4 Publications Verification Betamethasone 17,21-dipropionate	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology Cancer
Betamethasone dipropionate is a *glucocorticoid* steroid with anti-inflammatory and immunosuppressive abilities.

HY-14234

Glucocorticoid receptor agonist 1 Publications Verification	Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology Endocrinology
Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC₅₀ values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin .

HY-B1618S

Corticosterone-d8 1 Publications Verification	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-N0583S5

Hydrocortisone-d2 Cortisol-d₂	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology
Hydrocortisone-d₂ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-120012

Mizacorat 5+ Cited Publications AZD9567	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and *selective glucocorticoid* receptor modulator (SGRM), with an IC₅₀** of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation .

HY-14864

Mapracorat 1 Publications Verification ZK-245186; BOL-303242X	Glucocorticoid Receptor	Endocrinology
Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist.

HY-103548

GSK9027	Glucocorticoid Receptor	Endocrinology
GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2×glucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone .

HY-108243

AZD5423 2 Publications Verification	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM) . AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma .

HY-B0154S1

Fluticasone propionate-d5	Isotope-Labeled Compounds Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-136642

Fluocinolone	Glucocorticoid Receptor	Inflammation/Immunology
Fluocinolone is a potent steroid with highly selective glucocorticoid receptor agonist activity. Fluocinolone stabilizes the blood-retinal barrier by enhancing endothelial tight junctions, inhibiting the VEGF pathway and inflammatory factors. Fluocinolone has high lipophilicity, enabling long-term sustained release in the vitreous. Fluocinolone is used in research related to dermatological diseases, diabetic macular edema, uveitis and oral lichen planus .

HY-B1618S1

Corticosterone-d4 17-Deoxycortisol-d₄; 11β,21-Dihydroxyprogesterone-d₄; Kendall's compound B-d₄	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Neurological Disease Endocrinology
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-N0583S3

Hydrocortisone-d3 Cortisol-d₃	Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology Cancer
Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-77839R

Cortodoxone (Standard) 11-Deoxycortisol (Standard); cortexolone (Standard); Reichstein's substance S (Standard)	Reference Standards Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-151876

Glucocorticoid receptor modulator 1	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice .

HY-B0469R

Medroxyprogesterone acetate (Standard) 30+ Cited Publications Medroxyprogesterone 17-acetate(Standard); Farlutin (Standard)	Reference Standards Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite	Endocrinology Cancer
Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-13580R

Budesonide (Standard) 5+ Cited Publications	Reference Standards Glucocorticoid Receptor ADC Payload	Inflammation/Immunology Cancer
Budesonide (Standard) is the analytical standard of Budesonide. This product is intended for research and analytical applications. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-113364

5α-Tetrahydrocorticosterone 5α-THB	Glucocorticoid Receptor Endogenous Metabolite Drug Metabolite	Metabolic Disease Inflammation/Immunology
5α-Tetrahydrocorticosterone (5α-HB), an endogenous steroid, is a glucocorticoid receptor (GR) agonist and a metabolite of Corticosterone (HY-B1618). 5α-Tetrahydrocorticosterone is an effective topical anti-inflammatory agent in vivo. 5α-Tetrahydrocorticosterone reduces metabolites that bind to GR-Corticosterone and its 5α-reduced metabolites in rat hepatocytes, with a K_d of 268 nM. 5α-Tetrahydrocorticosterone can be used for research on inflammatory skin diseases .

HY-B1402R

Hydrocortisone hemisuccinate (Standard) Hydrocortisone 21-hemisuccinate (Standard)	Reference Standards Glucocorticoid Receptor Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate (Standard) is the analytical standard of Hydrocortisone hemisuccinate. This product is intended for research and analytical applications. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a physiological glucocorticoid, is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone hemisuccinate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate can be used for the research of ulcerative colitis (UC).

HY-116691

Hydrocortisone aceponate Hydrocortisone 17-propionate 21-acetate	Glucocorticoid Receptor	Neurological Disease Inflammation/Immunology
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a diester-based topical glucocorticoid. Hydrocortisone aceponate alleviates symptoms such as erythema, dryness/desquamation, pruritus, epidermal exfoliation, and exudation/crusting. Hydrocortisone aceponate causes extremely few adverse reactions. Hydrocortisone aceponate is applicable to various dermatological disease studies .

HY-B1829AR

Dexamethasone phosphate disodium (Standard) Dexamethasone 21-phosphate disodium (Standard)	Glucocorticoid Receptor Reference Standards Interleukin Related TGF-β Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium (Standard) is the analytical standard of Dexamethasone phosphate disodium (HY-B1829A). This product is intended for research and analytical applications. Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease).

HY-B0469S

Medroxyprogesterone acetate-d3 1 Publications Verification Medroxyprogesterone 17-acetate-d₃; Farlutin-d₃	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor	Endocrinology Cancer
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-B0154S

Fluticasone propionate-d3	Isotope-Labeled Compounds Glucocorticoid Receptor Enterovirus Endogenous Metabolite	Infection Inflammation/Immunology Endocrinology
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-113155A

17-Hydroxypregnenolone sulfate sodium	Drug Intermediate	Neurological Disease
17-Hydroxypregnenolone sulfate sodium is a key intermediate in adrenal and gonadal steroidogenesis. 17-Hydroxypregnenolone sulfate sodium acts as a precursor in the biosynthesis of steroid hormones (e.g., glucocorticoids, sex hormones). 17-Hydroxypregnenolone sulfate sodium is promising for research of adrenal function development and neurosteroid-related diseases (e.g., cognitive impairment, neurodegenerative diseases) .

HY-B1829

Dexamethasone phosphate 10+ Cited Publications Dexamethasone 21-phosphate	Glucocorticoid Receptor TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

HY-110408

Flurandrenolone Acetate	Drug Derivative	Inflammation/Immunology
Flurandrenolone Acetate is a derivative of Flurandrenolide (HY-B1013). Flurandrenolone Acetate is a synthetic glucocorticoid steroid, can be used for the research of skin disorders such as eczema and psoriasis .

HY-B1754

Rimexolone Org 6216; Rimexel	Glucocorticoid Receptor	Inflammation/Immunology
Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation .

HY-B1402A

Hydrocortisone hemisuccinate hydrate 1 Publications Verification Hydrocortisone 21-hemisuccinate hydrate	Interleukin Related	Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate hydrate (Hydrocortisone 21-hemisuccinate hydrate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate hydrate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate hydrate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .

HY-77839S1

Cortodoxone-d2 11-Deoxycortisol-d₂; cortexolone-d₂; Reichstein's substance S-d₂	Isotope-Labeled Compounds Glucocorticoid Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone) .

HY-125265

JTP-117968	Glucocorticoid Receptor	Metabolic Disease
JTP-117968, a novel selective glucocorticoid receptor modulator (a non-steroidal SGRM, IC₅₀ of 6.8 nM), exhibits improved transrepression/transactivation dissociation .

HY-136340

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione	Glucocorticoid Receptor NF-κB	Metabolic Disease Inflammation/Immunology
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization .

HY-144397

LEO 134310	Glucocorticoid Receptor	Inflammation/Immunology
LEO 134310 is a selective, non-steroidal glucocorticoid receptor (GR) agonist optimized for topical research., LEO 134310 showed high affinity (EC₅₀ of 14 nM) in a GR binding assay. LEO 134310 can be used for skin diseases .

HY-125839

OP-3633	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC₅₀ of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism .

HY-157294B

(Rac)-GSK866 GSK47866A	Glucocorticoid Receptor	Others
(Rac)-GSK866 (GSK47866A) is a non-steroidal glucocorticoid receptor (GR) ligand. The crystal structure of (Rac)-GSK866 bound to the GR LBD (3E7C) can be used as a model to study the mechanism of action of ligands of the same class .

HY-17358S1

Loteprednol Etabonate-d3	Isotope-Labeled Compounds Glucocorticoid Receptor Bacterial Antibiotic	Infection Inflammation/Immunology Endocrinology
Loteprednol Etabonate-d₃ is the deuterium labeled Loteprednol Etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology .

HY-W742981

Budesonide-d6	Isotope-Labeled Compounds Glucocorticoid Receptor ADC Payload	Inflammation/Immunology Cancer
Budesonide-d₆ is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

Cat. No.	Product Name	Type

HY-B1402G

Hydrocortisone hemisuccinate

Hydrocortisone 21-hemisuccinate

Fluorescent Dyes

Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) is a GMP-grade version of Hydrocortisone hemisuccinate (HY-B1402). GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers . .

Cat. No.	Product Name	Type

HY-B1402G

Hydrocortisone hemisuccinate

Hydrocortisone 21-hemisuccinate

Biochemical Assay Reagents

HY-NP0209

Hydrocortisone-OVA	Biochemical Assay Reagents
Hydrocortisone-OVA is a conjugate of Hydrocortisone (HY-N0583) and OVA peptide. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0583

Hydrocortisone Maximum Cited Publications 85 Publications Verification Cortisol	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification Cancer	Environmental Pollutants Endogenous Metabolite Glucocorticoid Receptor
Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-B0469

Medroxyprogesterone acetate 30+ Cited Publications Medroxyprogesterone 17-acetate; Farlutin	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite
Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-77839

Cortodoxone 4 Publications Verification 11-Deoxycortisol; cortexolone; Reichstein's substance S	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-N0583R

Hydrocortisone (Standard) Maximum Cited Publications 85 Publications Verification Cortisol (Standard)	Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification Cancer	Reference Standards Glucocorticoid Receptor Endogenous Metabolite
Hydrocortisone (Standard) is the analytical standard of Hydrocortisone. This product is intended for research and analytical applications. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-77839R

Cortodoxone (Standard) 11-Deoxycortisol (Standard); cortexolone (Standard); Reichstein's substance S (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards Glucocorticoid Receptor Endogenous Metabolite
Cortodoxone (Standard) is the analytical standard of Cortodoxone. This product is intended for research and analytical applications. Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-B0469R

Medroxyprogesterone acetate (Standard) 30+ Cited Publications Medroxyprogesterone 17-acetate(Standard); Farlutin (Standard)	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Reference Standards Progesterone Receptor Androgen Receptor Glucocorticoid Receptor Endogenous Metabolite
Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-B0154R

Fluticasone propionate (Standard)	Structural Classification Steroids Source Classification	Reference Standards Glucocorticoid Receptor Enterovirus Endogenous Metabolite ADC Payload
Fluticasone propionate (Standard) is the analytical standard of Fluticasone propionate. This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-N8550

Cortolone α-Cortolone	Structural Classification Endogenous metabolite Steroids Source Classification	Glucocorticoid Receptor
Cortolone (α-Cortolone) is a metabolite of the glucocorticoid cortisol (Hydrocortisone (HY-N0583)). Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.

Cat. No.	Product Name	Chemical Structure

HY-N0583S2

Hydrocortisone-d4
Hydrocortisone-d₄ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-N0583S1

Hydrocortisone-d7
Hydrocortisone-d₇ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-13580S

Budesonide-d8
Budesonide-d₈ is the deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-B1618S

Corticosterone-d8 1 Publications Verification
Corticosterone-d₈ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-N0583S5

Hydrocortisone-d2
Hydrocortisone-d₂ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-B0154S1

Fluticasone propionate-d5
Fluticasone propionate-d₅ is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-B1618S1

Corticosterone-d4
Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

HY-N0583S3

Hydrocortisone-d3
Hydrocortisone-d₃ is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .

HY-B0469S

Medroxyprogesterone acetate-d3 1 Publications Verification
Medroxyprogesterone acetate-d₃ is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

HY-B0154S

Fluticasone propionate-d3
Fluticasone propionate-d₃ is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity .

HY-77839S1

Cortodoxone-d2
Cortodoxone-d₂ is the deuterium labeled Cortodoxone. Cortodoxone is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone) .

HY-17358S1

Loteprednol Etabonate-d3
Loteprednol Etabonate-d₃ is the deuterium labeled Loteprednol Etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology .

HY-W742981

Budesonide-d6
Budesonide-d₆ is deuterium labeled Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma .

HY-13571S

Betamethasone dipropionate-d10
Betamethasone dipropionate-d₁₀ is the deuterium labeled Betamethasone dipropionate. Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-W740773

Betamethasone-d10 Dipropionate
Betamethasone-d₁₀ Dipropionate is the deuterium labeled Betamethasone dipropionate (HY-13571). Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.

HY-157568S

Budesonide acid-d8
Budesonide acid-d8 is a deuterium labeled Budesonide acid. Budesonide acid is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist .

HY-W653985

Cortodoxone-d7
Cortodoxone-d₇ (11-Deoxycortisol-d₇) is a deuterium labeled Cortodoxone (HY-77839). Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation .

HY-17358S

Loteprednol Etabonate-d5
Loteprednol Etabonate-d₅ is a deuterium labeled Loteprednol etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology .

HY-B0469S1

Medroxyprogesterone acetate-d7
Medroxyprogesterone acetate-d₇ (Medroxyprogesterone 17-acetate-d₇) is the deuterium labeled Medroxyprogesterone acetate (HY-B0469) . Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors .

Targets Recommended: Steroid Sulfatase Glucocorticoid Receptor SGK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1402G

Hydrocortisone hemisuccinate Hydrocortisone 21-hemisuccinate	Interleukin Related	Metabolic Disease Inflammation/Immunology Endocrinology
Hydrocortisone hemisuccinate GMP (Hydrocortisone 21-hemisuccinate GMP) is a GMP-grade version of Hydrocortisone hemisuccinate (HY-B1402). GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers . .

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