1177-87-3
Chemical Structure
Dexamethasone acetate
Synonym(s): Dexamethasone 21-acetate; Hexadecadrol acetate
- CAS No.: 1177-87-3
- Formula:C24H31FO6
- Molecular Weight:434.50
IUPAC Name: 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
InChIKey: AKUJBENLRBOFTD-RPRRAYFGSA-N
SMILES: C[C@@]1([C@@]2(O)C(COC(C)=O)=O)[C@](C[C@H]2C)([H])[C@@](CCC3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C1
Biological Activity: Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery[1][2][3][4].
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Dexamethasone acetate | 99.86% | Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery. | ||||||||||||||||||||
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Dexamethasone acetate (Standard) | 99.76% | Dexamethasone acetate (Standard) (Dexamethasone 21-acetate (Standard)) is the analytical standard of Dexamethasone acetate (HY-14648A). This product is intended for research and analytical applications. Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery. | ||||||||||||||||||||
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Dexamethasone acetate-d5 | 98.92% | Dexamethasone acetate-d5 (Dexamethasone 21-acetate-d5; Hexadecadrol acetate-d5) is the deuterium labeled Dexamethasone acetate (HY-14648A). Dexamethasone acetate (Dexamethasone 21-acetate) is the acetate form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone acetate has a longer duration of action than Dexamethasone. Dexamethasone acetate can accumulate at inflammatory sites, in mouse liver and mouse lung via nanostructured lipid carriers. Dexamethasone acetate can be used to prepare topical formulations for studies related to sensorineural hearing loss, γ-carrageenan-induced paw edema, chronic active hepatitis, pulmonary diseases, and inflammation after vitreoretinal surgery. | ||||||||||||||||||||
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Similarity Score 1.00
HY-13570BBetamethasone acetate -
Similarity Score 0.92
HY-W740582Betamethasone dipropionate impurity 5 -
Similarity Score 0.89
HY-139352Betamethasone 21-valerate -
Similarity Score 0.89
HY-Z7916Betamethasone impurity 2 -
Similarity Score 0.86
HY-160713Betamethasone succinate -
Similarity Score 0.86
HY-134116RIsoflupredone acetate (Standard) -
Similarity Score 0.85
HY-13570ABetamethasone hydrochloride -
Similarity Score 0.85
HY-13570RBetamethasone (Standard) -
Similarity Score 0.85
HY-14648Dexamethasone -
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References
- [1]. Du X, et al. Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs. Otol Neurotol. 2013;34(1):41-47. [Content Brief]
- [2]. Xu X, et al. Anti-inflammatory activity of injectable dexamethasone acetate-loaded nanostructured lipid carriers. Drug Deliv. 2011;18(7):485-492. [Content Brief]
- [3]. Da Silva GR, et al. Ocular biocompatibility of dexamethasone acetate loaded poly(ɛ-caprolactone) nanofibers. Eur J Pharm Biopharm. 2019;142:20-30. [Content Brief]
- [4]. Xiang QY, et al. Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch Pharm Res. 2007;30(4):519-525. [Content Brief]
