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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
glucose-dependent insulinotropic polypeptide (GIP) receptor
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "glucose-dependent insulinotropic polypeptide (GIP) receptor" in MCE Product Catalog:
26
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Tirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
1
1 Cited Publications
Cat. No.: HY-P2541A
Target:
Research Areas:
Cat. No.: HY-164535
CAS No.: 2887445-76-1
Synonyms: AMG 133
Research Areas:
Maridebart cafraglutide (AMG 133) is a long-acting peptide-antibody conjugate that combines GLP-1 receptor agonist with glucose-dependent insulinotropic polypeptide (GIP) receptor antagonism. Maridebart cafraglutide shows antagonist activity against human, cynomolgus monkey and rat GIPR with IC50 values of 46.4 nM, 26.5 nM, 822.3 nM, respectively. Maridebart cafraglutide shows agonist activity against human, cynomolgus monkey, rat and mouse GLP-1R with EC50 values of 24.4 pM, 5.7 pM, 2.4 pM and 123 pM, respectively. Maridebart cafraglutide can be used for the study of obesity and type 2 diabetes .
Cat. No.: HY-P10959
CAS No.: 2923558-68-1
Synonyms: LY3532226
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Research Areas:
Cat. No.: HY-P2542
CAS No.: 1802086-25-4
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Cat. No.: HY-P10959A
Synonyms: LY3532226 acetate
Target:
Research Areas:
Cat. No.: HY-P11321A
Synonyms: acyl-GIP hydrochloride
Target:
Research Areas:
Cat. No.: HY-P11321
Synonyms: acyl-GIP
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Cat. No.: HY-P2541
CAS No.: 134846-93-8
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Cat. No.: HY-P1731CP
CAS No.: 2023788-19-2
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Tirzepatide (LY3298176) (crude) is the crude form of Tirzepatide (HY-P1731).Tirzepatide (LY3298176) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity .
Cat. No.: HY-P702285
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
E. coli Cell-free
Cat. No.: HY-P702800
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P702801
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P702802
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Rat
Source:
HEK293
Cat. No.: HY-P702803
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Cynomolgus
Source:
P. pastoris
Cat. No.: HY-P703990
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P703685
Purity: ≥ 95%, as determined by reducing Bis-Tris PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P703965
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P703982
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GIPR; GIP-R; Gastric Inhibitory polypeptide receptor; PGQTL2; glucose-dependent insulinotropic polypeptide receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-P0276F
Target:
Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
