2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. IUB0271 hydrochloride

IUB0271 hydrochloride  (Synonyms: acyl-GIP hydrochloride)

Cat. No.: HY-P11321A Purity: 98.67%
COA
SDS
Handling Instructions Technical Support

IUB0271 (acyl-GIP) hydrochloride is a fatty acylated and long-acting glucose-dependent insulinotropic polypeptide (GIP). IUB0271 hydrochloride increases cFos neuronal activity in hypothalamic feeding centers and decreases body weight, food intake and glycemia in DIO mouse models, and these effects depend on CNS-GIPR signaling. IUB0271 hydrochloride can be used for type 2 diabetes mellitus (T2DM) and obesity research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

IUB0271 hydrochloride

IUB0271 hydrochloride Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of IUB0271 hydrochloride:

IUB0271 hydrochloride Related Antibodies

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Description

IUB0271 (acyl-GIP) hydrochloride is a fatty acylated and long-acting glucose-dependent insulinotropic polypeptide (GIP). IUB0271 hydrochloride increases cFos neuronal activity in hypothalamic feeding centers and decreases body weight, food intake and glycemia in DIO mouse models, and these effects depend on CNS-GIPR signaling. IUB0271 hydrochloride can be used for type 2 diabetes mellitus (T2DM) and obesity research[1].

Molecular Weight

5751.48 (free base)

Formula

C264H403N65O77S·xHCl
Appearance

Solid

Color

White to off-white

Sequence

Tyr-{Aib}-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-Lys(γGlu-γGlu-γGlu-C16)
Sequence Shortening

Y-{Aib}-EGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ-Lys(γGlu-γGlu-γGlu-C16)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL

H2O : ≥ 25 mg/mL

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.67%

SDS (252 KB)

COA (273 KB) RP-HPLC (112 KB) MS (189 KB) Elemental Analysis Report (131 KB)

Handling Instructions (2659 KB)
References
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IUB0271 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IUB0271acyl-GIPIUB 0271IUB-0271Insulin ReceptorGIPFatty acylatedLong-actingcFosDIO mouse modelsCNS-GIPR signalingT2DMObesityInhibitorinhibitorinhibit

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