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Results for "

glycation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (6) Akt (5) Aldose Reductase (8) Amylases (1) Amyloid-β (11) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) AP-1 (2) Apoptosis (8) Autophagy (2) Bacterial (5) Biochemical Assay Reagents (6) Caspase (2) Cathepsin (1) CCR (1) CDK (1) Cholinesterase (ChE) (1) COX (5) Cytochrome P450 (2) Dipeptidyl Peptidase (4) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (2) EAAT (1) Endogenous Metabolite (22) Environmental Pollutants (1) ERK (2) Fc Receptor (FcR) (1) Ferroptosis (1) Fungal (2) FXR (1) GABA Receptor (3) GLP Receptor (1) Glycosidase (5) Glycosyltransferase (1) Glyoxalase (GLO) (1) HIV (2) Influenza Virus (2) Insulin Receptor (1) Interleukin Related (3) Isotope-Labeled Compounds (6) Keap1-Nrf2 (3) Lipocalin Family (1) Lipoxygenase (1) Mitochondrial Metabolism (1) Mitophagy (3) MMP (1) Monoamine Oxidase (1) mTOR (3) Neurokinin Receptor (2) NF-κB (2) NO Synthase (5) p38 MAPK (3) Parasite (1) PARP (1) PD-1/PD-L1 (2) PGE synthase (1) PI3K (3) PKC (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) Ras (2) Reactive Oxygen Species (ROS) (8) Reference Standards (19) Serotonin Transporter (1) SOD (1) STAT (2) Tim3 (2) TNF Receptor (3) Toll-like Receptor (TLR) (4) Transmembrane Glycoprotein (1) Trk Receptor (1) Tyrosinase (1) Wnt (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (28) Cardiovascular Disease (10) Endocrinology (9) Infection (9) Inflammation/Immunology (35) Metabolic Disease (58) Neurological Disease (25)

By Targets:

Adrenergic Receptor (6)

Akt (5)

Aldose Reductase (8)

Amylases (1)

Amyloid-β (11)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

AP-1 (2)

Apoptosis (8)

Autophagy (2)

Bacterial (5)

Biochemical Assay Reagents (6)

Caspase (2)

Cathepsin (1)

CCR (1)

CDK (1)

Cholinesterase (ChE) (1)

COX (5)

Cytochrome P450 (2)

Dipeptidyl Peptidase (4)

DNA/RNA Synthesis (1)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (2)

EAAT (1)

Endogenous Metabolite (22)

Environmental Pollutants (1)

ERK (2)

Fc Receptor (FcR) (1)

Ferroptosis (1)

Fungal (2)

FXR (1)

GABA Receptor (3)

GLP Receptor (1)

Glycosidase (5)

Glycosyltransferase (1)

Glyoxalase (GLO) (1)

HIV (2)

Influenza Virus (2)

Insulin Receptor (1)

Interleukin Related (3)

Isotope-Labeled Compounds (6)

Keap1-Nrf2 (3)

Lipocalin Family (1)

Lipoxygenase (1)

Mitochondrial Metabolism (1)

Mitophagy (3)

MMP (1)

Monoamine Oxidase (1)

mTOR (3)

Neurokinin Receptor (2)

NF-κB (2)

NO Synthase (5)

p38 MAPK (3)

Parasite (1)

PARP (1)

PD-1/PD-L1 (2)

PGE synthase (1)

PI3K (3)

PKC (1)

Polo-like Kinase (PLK) (1)

Potassium Channel (1)

Ras (2)

Reactive Oxygen Species (ROS) (8)

Reference Standards (19)

Serotonin Transporter (1)

SOD (1)

STAT (2)

Tim3 (2)

TNF Receptor (3)

Toll-like Receptor (TLR) (4)

Transmembrane Glycoprotein (1)

Trk Receptor (1)

Tyrosinase (1)

Wnt (2)

Xanthine Oxidase (1)

By Research Areas:

Cancer (28)

Cardiovascular Disease (10)

Endocrinology (9)

Infection (9)

Inflammation/Immunology (35)

Metabolic Disease (58)

Neurological Disease (25)

107

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0022

Isoacteoside 5+ Cited Publications Isoverbascoside	Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

HY-141537

ABR-238901 5 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
ABR-238901 is an orally active and potent S100A8/A9 blocker and inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4). ABR-238901 has the potential for myocardial infarction (MI) research .

HY-50682

Azeliragon Maximum Cited Publications 16 Publications Verification TTP488; PF-04494700	Amyloid-β	Neurological Disease Cancer
Azeliragon (TTP488) is an orally bioavailable inhibitor of the *receptor for advanced glycation* end products (RAGE)** in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .

HY-113354

Anserine 5 Publications Verification	Endogenous Metabolite	Neurological Disease
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine has blood-brain barrier permeability, and improves memory functions in Alzheimer's disease (AD)-model mice .

HY-B1041

Aminoguanidine hydrochloride 5+ Cited Publications Pimagedine hydrochloride; GER-11; Aminoguanidinium chloride	NO Synthase Apoptosis ERK	Neurological Disease Metabolic Disease Inflammation/Immunology
Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy .

HY-N0033

Poliumoside Maximum Cited Publications 8 Publications Verification	Aldose Reductase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-106024B

Alagebrium chloride 5+ Cited Publications ALT711	Endogenous Metabolite	Metabolic Disease
Alagebrium chloride (ALT711) is an *advanced glycation* end product (AGE**) inhibitor.

HY-W018772

D-Ribose(mixture of isomers) 5 Publications Verification	Endogenous Metabolite	Inflammation/Immunology Cancer
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-B1235

Acetohydroxamic acid 1 Publications Verification N-Hydroxyacetamide	Bacterial HIV	Infection Inflammation/Immunology
Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV .

HY-N7426

3-Deoxyglucosone 3-Deoxy-D-glucosone	GLP Receptor	Metabolic Disease
3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes .

HY-N2165

Vicenin 2 Maximum Cited Publications 8 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Vicenin 2, a flavonoid, is an orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ of 43.83 μM) . Vicenin 2 has radioprotective, anti-nociceptive effects, anti-glycation anti-inflammatory, antioxidant, anticancer, antiangiogenic properties .

HY-14892A

Gemigliptin tartrate LC15-0444 tartrate	Dipeptidyl Peptidase	Metabolic Disease
Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-B1392

Esmolol hydrochloride 3 Publications Verification	Adrenergic Receptor Caspase Apoptosis Aldose Reductase Neurokinin Receptor	Cardiovascular Disease Endocrinology Cancer
Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptor. Esmolol hydrochloride attenuates post resuscitation myocardial dysfunction. Esmolol hydrochloride improves diabetic wound healing by inhibiting aldose reductase and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .

HY-W286743

Nε-(Carboxymethyl)-L-lysine 1 Publications Verification CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine	Polo-like Kinase (PLK) ERK NF-κB	Cancer
Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties .

HY-NP165

*Advanced glycation* end products** AGEs	Biochemical Assay Reagents	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Advanced glycation end products (AGEs) are a series of stable compounds generated through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. Advanced glycation end products are often used as targets to evaluate the inhibitory effects of anti-glycation compounds. Advanced glycation end products can be applied to research on diabetes, cardiovascular and cerebrovascular diseases, inflammation, aging, and other conditions .

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-B1745

Pyridoxylamine 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease
Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

HY-N1495

Maltopentaose Maltopentose	Amylases	Others
Maltopentaose is the shortest chain oligosaccharide. Maltopentaose is a substrate for α-amylases. Maltopentaose can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin. Maltopentaose is used to study the inhibition kinetics of human pancreatic α-amylase by dehydrodieugenol B .

HY-129611

Bromelain	Apoptosis	Inflammation/Immunology Cancer
Bromelain is an anti-inflammatory agent derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway . Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death .

HY-W019724

2,2-Dihydroxyacetic acid	Drug Intermediate Reactive Oxygen Species (ROS)	Neurological Disease Metabolic Disease Cancer
2,2-Dihydroxyacetic acid is an endogenous metabolite, which is the monohydrate of Glyoxylic Acid. 2,2-Dihydroxyacetic acid may participate in the microbial glyoxylate cycle, induce an increase in reactive oxygen species, promote cell differentiation, and modify proteins to form advanced glycation end products (AGEs) (HY-NP165). 2,2-Dihydroxyacetic acid is associated with metabolic diseases such as primary hyperoxaluria .

HY-N0761

Isoferulic acid 3 Publications Verification 3-Hydroxy-4-methoxycinnamic acid	Adrenergic Receptor Influenza Virus	Infection Metabolic Disease Inflammation/Immunology Endocrinology
Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is an orally active cinnamic acid derivative. Isoferulic acid exhibits hypoglycemic, antiviral, and antioxidant activities. Isoferulic acid can also inhibit fructose- and glucose-mediated protein glycation. Isoferulic acid can be used in the research of diseases such as diabetes .

HY-P2268

RAGE antagonist peptide 4 Publications Verification	Amyloid-β	Inflammation/Immunology Cancer
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities .

HY-N4089

Quercetin 3-gentiobioside	Aldose Reductase Cytochrome P450	Metabolic Disease Cancer
Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma .

HY-124750

NecroX-7	TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology
NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .

HY-107207

Kaempferol 3-neohesperidoside 3 Publications Verification Kaempferol 3-O-neohesperidoside	Insulin Receptor PI3K PKC	Metabolic Disease
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .

HY-B1745A

Pyridoxylamine dihydrochloride 5+ Cited Publications	Endogenous Metabolite	Metabolic Disease
Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions .

HY-N1470

Plantagoside	Glycosidase	Metabolic Disease
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-76383

LR-90	COX	Metabolic Disease Inflammation/Immunology
LR-90 is an *advanced glycation* end product (AGE)** inhibitor, inhibits inflammatory responses in human monocytes . LR-90 is also used in the research of diabetic animal model .

HY-N4170

Chebulic acid 2 Publications Verification	Keap1-Nrf2 Reactive Oxygen Species (ROS)	Metabolic Disease
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

HY-N2907

Atranorin	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT	Infection Neurological Disease Inflammation/Immunology Cancer
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-W749694

Cannflavin B Canniflavone	Ferroptosis Parasite PGE synthase Lipoxygenase Trk Receptor p38 MAPK mTOR Akt	Infection Neurological Disease Inflammation/Immunology Cancer
Cannflavin B is a flavonoid compound that can be isolated from Cannabis sativa L. Cannflavin B is inhibitors of PGE₂ release (IC₅₀: 0.7 μM), mPGES-1 (IC₅₀: 3.7 μM), and 5-lipoxygenase. Cannflavin B has multiple activities such as anti-inflammatory, antioxidant, anti-glycation, anti-ferroptosis, anti-tumor, and anti-Leishmania (IC₅₀: 14 μM). Cannflavin B can also inhibit the TrkB-BDNF signaling pathway .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-P2268A

RAGE antagonist peptide TFA 4 Publications Verification	Amyloid-β	Inflammation/Immunology Cancer
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities .

HY-113354S

Anserine-d4	Endogenous Metabolite	Neurological Disease
Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-141508

Flazin	Xanthine Oxidase NO Synthase	Neurological Disease Metabolic Disease Inflammation/Immunology
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO ^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO ^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .

HY-113033

Pentosidine	Others Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-14892

Gemigliptin LC15-0444	Dipeptidyl Peptidase	Metabolic Disease Cancer
Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-114883

Homocarnosine L-Homocarnosine	GABA Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-N10616

Pseudobaptigenin 1 Publications Verification	Others	Metabolic Disease
Pseudobaptigenin is a flavonoid. Pseudobaptigenin shows very good anticataract activity. Pseudobaptigenin has good binding affinity for the inhibition of glycation against γ-crystallin protein. Pseudobaptigenin also has good ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) property .

HY-N7628

Cassiaside C Toralactone 9-O-β-D-gentiobioside	Endogenous Metabolite	Metabolic Disease
Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro .

HY-W585874

Nε-(Carboxyethyl)lysine	EAAT Apoptosis	Neurological Disease Metabolic Disease
Nε-(Carboxyethyl) lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl) lysine induces cross-linking between proteins, thereby affecting protein structure and function and causing protein denaturation. Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cell signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis. Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, influences neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity .

HY-Y0785

Glyoxal (40% w/w in water)	Drug Metabolite	Metabolic Disease
Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones .

HY-114883A

Homocarnosine TFA L-Homocarnosine TFA	GABA Receptor Endogenous Metabolite	Neurological Disease
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-W018772S15

D-Ribose(mixture of isomers)-13C5	Endogenous Metabolite	Inflammation/Immunology
D-Ribose(mixture of isomers)- ¹³C₅ isomers)- ¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-Y0785S

Glyoxal-d2	Isotope-Labeled Compounds Drug Metabolite	Metabolic Disease
Glyoxal-d₂ is the deuterium labeled Glyoxal (HY-Y0785). Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones .

HY-N8375

Sieboldin	Others	Metabolic Disease
Sieboldin is a dihydrochalcone, which inhibits the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA), has free radical scavenging activity and cytotoxicity in cancer cell lines, and is also used to capture of methylglyoxal (MGO) from Malus baccata .

HY-W018772R

D-Ribose(mixture of isomers) (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology Cancer
D-Ribose(mixture of isomers) (Standard) is the analytical standard of D-Ribose(mixture of isomers). This product is intended for research and analytical applications. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-B1235R

Acetohydroxamic acid (Standard) N-Hydroxyacetamide (Standard)	Reference Standards Bacterial HIV	Infection Inflammation/Immunology
Acetohydroxamic acid (Standard) is the analytical standard of Acetohydroxamic acid. This product is intended for research and analytical applications. Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV .

HY-14892C

Gemigliptin hydrochloride LC15-0444 hydrochloride	Dipeptidyl Peptidase	Metabolic Disease Cancer
Gemigliptin hydrochloride is the hydrochloride salt of Gemigliptin (HY-14892). Gemigliptin hydrochloride is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin hydrochloride exhibits potent anti-glycation properties. Gemigliptin hydrochloride can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-B1745R

Pyridoxylamine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Pyridoxylamine (Standard) is the analytical standard of Pyridoxylamine. This product is intended for research and analytical applications. Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

Cat. No.	Product Name	Type

HY-NP008

β-Lactoglobulin

Biochemical Assay Reagents

β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products .

HY-W286743

Nε-(Carboxymethyl)-L-lysine

1 Publications Verification

CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine

Biochemical Assay Reagents

Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties .

HY-NP165

Advanced glycation end products

AGEs

Biochemical Assay Reagents

Advanced glycation end products (AGEs) are a series of stable compounds generated through non-enzymatic reactions between reducing sugars and proteins, lipids, or nucleic acids. Advanced glycation end products are often used as targets to evaluate the inhibitory effects of anti-glycation compounds. Advanced glycation end products can be applied to research on diabetes, cardiovascular and cerebrovascular diseases, inflammation, aging, and other conditions .

HY-116956A

L-Erythrose (solution) (70%w/w in water)	Biochemical Assay Reagents
L-Erythrose (solution) (70% in water) is an aldose carbohydrate that has been used in glycation studies and to characterize erythrose reductase activity.

HY-W040288A

L-Threose (solution),0.5M	Biochemical Assay Reagents
L-Threose (solution), 0.5M is a 0.5 M solution of L-Threose in water. L-Threose is a substrate for Aldose Reductase and may prevent protein glycation .

Cat. No.	Product Name	Target	Research Area

HY-P2268

RAGE antagonist peptide 4 Publications Verification	Amyloid-β	Inflammation/Immunology Cancer
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide (RAP) possesses anti-tumor and anti-inflammatory activities .

HY-P2268A

RAGE antagonist peptide TFA 4 Publications Verification	Amyloid-β	Inflammation/Immunology Cancer
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities .

HY-114883

Homocarnosine L-Homocarnosine	GABA Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-114883A

Homocarnosine TFA L-Homocarnosine TFA	GABA Receptor Endogenous Metabolite	Neurological Disease
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-P0109

(S,S)-Z-FA-FMK	Cathepsin	Others
(S,S)-Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S,S)-Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S,S)-Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992465

SIWA318H	Fc Receptor (FcR)	Cancer
SIWA318H is an adbanvced glycation end product (AGE) specific antibody. SIWA318H selectively binds to advanced glycation end product biomarkers, human FcγRIIIa, and pancreatic cancer cells, and cancer-associated fibroblasts. SIWA318H suppresses tumor growth in mouse PSN1 xenografts. SIWA318H can be used for the research of pancreatic cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0022

Isoacteoside 5+ Cited Publications Isoverbascoside	Classification of Application Fields Simple Phenylpropanols Cistanche deserticola Ma Metabolic Disease Orobanchaceae Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK Toll-like Receptor (TLR) Amyloid-β
Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

HY-113354

Anserine 5 Publications Verification	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Endogenous Metabolite
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine has blood-brain barrier permeability, and improves memory functions in Alzheimer's disease (AD)-model mice .

HY-N0033

Poliumoside Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Classification of Application Fields Callicarpa formosana Rolfe Plants Simple Phenylpropanols Verbenaceae Scrophulariaceae Phenols Polyphenols Phenylpropanoids Disease Research Fields Inflammation/Immunology Source Classification Brandisia hancei Hook. f.	Aldose Reductase
Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-106024B

Alagebrium chloride 5+ Cited Publications ALT711	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Alagebrium chloride (ALT711) is an *advanced glycation* end product (AGE**) inhibitor.

HY-W018772

D-Ribose(mixture of isomers) 5 Publications Verification	Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Source Classification Cancer	Endogenous Metabolite
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-N7426

3-Deoxyglucosone 3-Deoxy-D-glucosone	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	GLP Receptor
3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes .

HY-N2165

Vicenin 2 Maximum Cited Publications 8 Publications Verification	Cardiovascular Disease Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavones Phenols Polyphenols Plants Disease Research Fields Desmodium styracifolium (Osbeck.) Merr.	Angiotensin-converting Enzyme (ACE)
Vicenin 2, a flavonoid, is an orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ of 43.83 μM) . Vicenin 2 has radioprotective, anti-nociceptive effects, anti-glycation anti-inflammatory, antioxidant, anticancer, antiangiogenic properties .

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-B1745

Pyridoxylamine 5+ Cited Publications	Human Gut Microbiota Metabolites Natural Products Microorganisms Classification of Application Fields Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

HY-N1495

Maltopentaose Maltopentose	Human Gut Microbiota Metabolites Polysaccharides Microorganisms Classification of Application Fields Gramineae Hordeum vulgare L. Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides Source Classification	Amylases
Maltopentaose is the shortest chain oligosaccharide. Maltopentaose is a substrate for α-amylases. Maltopentaose can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin. Maltopentaose is used to study the inhibition kinetics of human pancreatic α-amylase by dehydrodieugenol B .

HY-W019724

2,2-Dihydroxyacetic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate Reactive Oxygen Species (ROS)
2,2-Dihydroxyacetic acid is an endogenous metabolite, which is the monohydrate of Glyoxylic Acid. 2,2-Dihydroxyacetic acid may participate in the microbial glyoxylate cycle, induce an increase in reactive oxygen species, promote cell differentiation, and modify proteins to form advanced glycation end products (AGEs) (HY-NP165). 2,2-Dihydroxyacetic acid is associated with metabolic diseases such as primary hyperoxaluria .

HY-N0761

Isoferulic acid 3 Publications Verification 3-Hydroxy-4-methoxycinnamic acid	Monophenols Classification of Application Fields Simple Phenylpropanols Ranunculaceae Metabolic Disease Phenols Phenylpropanoids Plants Cimicifuga foetida Linn. Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Influenza Virus
Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is an orally active cinnamic acid derivative. Isoferulic acid exhibits hypoglycemic, antiviral, and antioxidant activities. Isoferulic acid can also inhibit fructose- and glucose-mediated protein glycation. Isoferulic acid can be used in the research of diseases such as diabetes .

HY-N4089

Quercetin 3-gentiobioside	Structural Classification Flavonols other families Flavonoids Classification of Application Fields Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Source Classification	Aldose Reductase Cytochrome P450
Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma .

HY-107207

Kaempferol 3-neohesperidoside 3 Publications Verification Kaempferol 3-O-neohesperidoside	Structural Classification Flavonols Flavonoids Classification of Application Fields Typhaceae Typha orientalis Presl Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Source Classification	Insulin Receptor PI3K PKC
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .

HY-B1745A

Pyridoxylamine dihydrochloride 5+ Cited Publications	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions .

HY-N1470

Plantagoside	Plantaginaceae Structural Classification Flavonoids Classification of Application Fields Flavonones Metabolic Disease Phenols Polyphenols Plantago asiatica L. Plants Disease Research Fields Source Classification	Glycosidase
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-N4170

Chebulic acid 2 Publications Verification	Classification of Application Fields Combretaceae Ketones, Aldehydes, Acids Metabolic Disease Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields Source Classification	Keap1-Nrf2 Reactive Oxygen Species (ROS)
Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection .

HY-N2907

Atranorin	other families Classification of Application Fields Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	Wnt Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-W749694

Cannflavin B Canniflavone	Flavonoids Cannabis sativa L Flavones Plants Moraceae Source Classification	Ferroptosis Parasite PGE synthase Lipoxygenase Trk Receptor p38 MAPK mTOR Akt
Cannflavin B is a flavonoid compound that can be isolated from Cannabis sativa L. Cannflavin B is inhibitors of PGE₂ release (IC₅₀: 0.7 μM), mPGES-1 (IC₅₀: 3.7 μM), and 5-lipoxygenase. Cannflavin B has multiple activities such as anti-inflammatory, antioxidant, anti-glycation, anti-ferroptosis, anti-tumor, and anti-Leishmania (IC₅₀: 14 μM). Cannflavin B can also inhibit the TrkB-BDNF signaling pathway .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-141508

Flazin	Simaroubaceae Plants Source Classification Indole Alkaloids Brucea javanica (L.) Merr.	Xanthine Oxidase NO Synthase
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO ^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO ^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .

HY-113033

Pentosidine	Structural Classification Natural Products Disease markers Endogenous metabolite Source Classification	Others Biochemical Assay Reagents
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-114883

Homocarnosine L-Homocarnosine	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Inflammation/Immunology Source Classification	GABA Receptor Endogenous Metabolite
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-N10616

Pseudobaptigenin 1 Publications Verification	Flavonoids Leguminosae Flavones Plants Pterocarpus marsupium Roxb.	Others
Pseudobaptigenin is a flavonoid. Pseudobaptigenin shows very good anticataract activity. Pseudobaptigenin has good binding affinity for the inhibition of glycation against γ-crystallin protein. Pseudobaptigenin also has good ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) property .

HY-N7628

Cassiaside C Toralactone 9-O-β-D-gentiobioside	Cassia tora (L.) Roxb. Monophenols Classification of Application Fields Leguminosae Metabolic Disease Phenols Plants Disease Research Fields Source Classification	Endogenous Metabolite
Cassiaside C (Toralactone 9-O-β-D-gentiobioside) is a naphthopyrone isolated from the seed of Cassia tora and has inhibitory activity on advanced glycation end products (AGE) formation in vitro .

HY-114883A

Homocarnosine TFA L-Homocarnosine TFA	Structural Classification Natural Products Classification of Application Fields Neurological Disease Endogenous metabolite Disease Research Fields Source Classification	GABA Receptor Endogenous Metabolite
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-N8375

Sieboldin	Balanophora involucrata Hook. f. Plants Balanophoraceae Saccharides Source Classification Monosaccharides	Others
Sieboldin is a dihydrochalcone, which inhibits the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA), has free radical scavenging activity and cytotoxicity in cancer cell lines, and is also used to capture of methylglyoxal (MGO) from Malus baccata .

HY-W018772R

D-Ribose(mixture of isomers) (Standard)	Structural Classification Microorganisms Endogenous metabolite Saccharides Source Classification	Reference Standards Endogenous Metabolite
D-Ribose(mixture of isomers) (Standard) is the analytical standard of D-Ribose(mixture of isomers). This product is intended for research and analytical applications. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-B1745R

Pyridoxylamine (Standard)	Structural Classification Human Gut Microbiota Metabolites Natural Products Microorganisms Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Pyridoxylamine (Standard) is the analytical standard of Pyridoxylamine. This product is intended for research and analytical applications. Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.

HY-N7069

4-Isopropylbenzyl alcohol	Camellia nitidissima Structural Classification Natural Products Classification of Application Fields Plants Disease Research Fields Source Classification Cancer Theaceae	Environmental Pollutants
4-Isopropylbenzyl alcohol is a chemical composition of the essential oils from the leaves and flowers of Camellia nitidissima. C. nitidissima possess multiple biological activities including antioxidant activity, anticancer activity, and cytotoxicity as well as inhibiting the formation of advanced glycation end-products .

HY-N6883

6-Methoxytricin	other families Flavonoids Classification of Application Fields Flavones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields Source Classification	Aldose Reductase
6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC₅₀ values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent .

HY-N0022R

Isoacteoside (Standard) Isoverbascoside (Standard)	Structural Classification Simple Phenylpropanols Cistanche deserticola Ma Orobanchaceae Phenols Polyphenols Phenylpropanoids Plants Source Classification	Toll-like Receptor (TLR) Amyloid-β Reference Standards Apoptosis Reactive Oxygen Species (ROS) Akt mTOR PI3K NO Synthase COX p38 MAPK
Isoacteoside (Standard) is the analytical standard of Isoacteoside. This product is intended for research and analytical applications. Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside Standard regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside Standard exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities .

HY-N2907R

Atranorin (Standard)	Structural Classification other families Phenols Polyphenols Plants Endogenous metabolite Source Classification	Wnt Reference Standards Ras Endogenous Metabolite Bacterial Fungal PD-1/PD-L1 Tim3 Akt AP-1 STAT
Atranorin (Standard) is the analytical standard of Atranorin (HY-N2907). This product is intended for research and analytical applications. Atranorin is a secondary metabolite of lichens and AKT inhibitor. Atranorin possesses multiple activities such as antibacterial, anti-inflammatory, antioxidant, anti-glycation, analgesic, and anti-tumor effects. Atranorin has IC₅₀ values for scavenging DPPH and ABTS free radicals of 117 μM and less than 10 μM, respectively. Additionally, Atranorin also exhibits effects in promoting wound healing. Atranorin can be used in the research of various diseases, including myelodysplastic syndromes, tumors, and inflammatory conditions .

HY-N12071

Lucidin-ω-Me ether	Quinones Anthraquinones Rubiaceae Knoxia valerianoides Thorel ex Pitard Plants Source Classification	Others
Lucidin-ω-Me ether (Compound 2) can be isolated from the roots of Knoxia valerianoides. Lucidin-ω-Me ether inhibits the advanced glycation end products (AGEs) formation in vitro(IC₅₀: 62.79 μM) .

HY-129380AR

Fructosyl-lysine dihydrochloride (Standard) Fructoselysine dihydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection .

HY-N0033R

Poliumoside (Standard)	Structural Classification Simple Phenylpropanols Verbenaceae Scrophulariaceae Callicarpa formosana Rolfe Phenols Polyphenols Phenylpropanoids Plants Source Classification Brandisia hancei Hook. f.	Reference Standards Aldose Reductase
Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC₅₀s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity .

HY-N1495R

Maltopentaose (Standard) Maltopentose (Standard)	Structural Classification Human Gut Microbiota Metabolites Polysaccharides Microorganisms Gramineae Hordeum vulgare L. Plants Endogenous metabolite Saccharides Source Classification	Reference Standards Endogenous Metabolite
Maltopentaose (Standard) is the analytical standard of Maltopentaose. This product is intended for research and analytical applications. Maltopentaose is the shortest chain oligosaccharide that can be classified as maltodextrin and is also used in a study to investigate glycation and phosphorylation of α-lactalbumin.

HY-B1745AR

Pyridoxylamine dihydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Pyridoxylamine (dihydrochloride) (Standard) is the analytical standard of Pyridoxylamine (dihydrochloride). This product is intended for research and analytical applications. Pyridoxylamine dihydrochloride is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions .

HY-N12689

α-Glucosidase-IN-56	Pistacia chinensis Bunge Phenols Polyphenols Plants Source Classification Anacardiaceae	Glycosidase
α-Glucosidase-IN-56 (compound 1) is an orally active, potent α‐glucosidase inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities .

HY-107207R

Kaempferol 3-neohesperidoside (Standard) Kaempferol 3-O-neohesperidoside (Standard)	Structural Classification Flavonols Flavonoids Typhaceae Typha orientalis Presl Phenols Polyphenols Plants Source Classification	Reference Standards Others
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) Standard is the analytical standard of Kaempferol 3-neohesperidoside (HY-107207). This product is intended for research and analytical applications. Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .

HY-113354R

Anserine (Standard)	Structural Classification Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Anserine (Standard) is the analytical standard of Anserine. This product is intended for research and analytical applications. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].

HY-129380R

Fructosyl-lysine (Standard) Fructoselysine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Diethylene glycol (Standard) is the analytical standard of Diethylene glycol. This product is intended for research and analytical applications. 2,2'-Oxybis(ethan-1-ol) (DIETHYLENE GLYCOL) has excellent solubility and reactivity in certain chemical reactions and can help accelerate the activation of certain reactants. In addition, it is widely used in the production process of pigments, resins and other chemicals. Although the compound has no direct medical application, it has wide applications in chemical research and industrial production.

HY-N0761R

Isoferulic acid (Standard) 3-Hydroxy-4-methoxycinnamic acid (Standard)	Structural Classification Monophenols Simple Phenylpropanols Ranunculaceae Phenols Phenylpropanoids Plants Cimicifuga foetida Linn. Source Classification	Reference Standards Adrenergic Receptor Influenza Virus
Isoferulic acid (Standard) (3-Hydroxy-4-methoxycinnamic acid (Standard)) is the analytical standard of Isoferulic acid (HY-N0761). This product is intended for research and analytical applications. Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is an orally active cinnamic acid derivative. Isoferulic acid exhibits hypoglycemic, antiviral, and antioxidant activities. Isoferulic acid can also inhibit fructose- and glucose-mediated protein glycation. Isoferulic acid can be used in the research of diseases such as diabetes .

HY-N4089R

Quercetin 3-gentiobioside (Standard)	Structural Classification Flavonols other families Flavonoids Phenols Polyphenols Plants Source Classification	Reference Standards Aldose Reductase Cytochrome P450
Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside (HY-N4089). This product is intended for research and analytical applications. Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an K_i of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC₅₀ values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma .

HY-N15415

Zaluzanin C	Structural Classification Strobocalyx arborea (Buch.-Ham.) Sch. Bip. Terpenoids Sesquiterpenes Plants Compositae Source Classification	Reactive Oxygen Species (ROS) NF-κB Mitochondrial Metabolism Mitophagy Glycosidase
Zaluzanin C is a sesquiterpene lactone and antifungal agent. Zaluzanin C is isolated from the leaves of Vernonia arborea. Zaluzanin C inhibits mtROS-mediated NF-κB activity, as well as LPS- and TNF-α-induced mtROS production. Zaluzanin C alleviates mtROS-mediated mitochondrial dysfunction, enhances Mitophagy, and increases the mRNA levels of fatty acid oxidation genes and mitochondrial biogenesis factors. Zaluzanin C inhibits the formation of advanced glycation end products and α-glucosidase activity. Zaluzanin C improves intracellular lipid accumulation. Zaluzanin C exhibits anti-inflammatory, antioxidant, antifungal, anticancer and pro-osteogenic activities. Zaluzanin C can be used in studies related to non-alcoholic fatty liver disease and obesity .

HY-N18363

5,7-Naringenin dimethyl ether	Structural Classification Flavonoids Viscum coloratum (Kom.) Nakai Flavonones Plants Loranthaceae Source Classification	Others
5,7-Naringenin dimethyl ether is a flavanone compound with anti-glycation activity .

HY-N17803

Fisetin tetramethyl ether 3,3',4',7-Tetramethoxyflavone	Structural Classification Pongamia pinnata (L.) Pierre Flavonoids Flavones Plants Source Classification Fabaceae	Others
Fisetin tetramethyl ether (3,3',4',7-Tetramethoxyflavone) is a flavonoid compound. Fisetin tetramethyl ether can be isolated from the stem bark of Derris indica. Fisetin tetramethyl ether shows no inhibitory activity against the formation of advanced glycation end products .

HY-N13261

Brickellin	Structural Classification Flavonoids Chrysosplenium grayanum Maxim. Flavones Plants Saxifragaceae Source Classification	Others
Brickellin is an antioxidant agent that can be isolated from Varronia curassavica Jacq.. Brickellin inhibits advanced glycation end products (AGEs) formation, protein crosslinking, and oxidative damage to proteins. Brickellin can be used for the research of diabetes .

HY-N18965

Formyline	Structural Classification Alkaloids Pyrrole Alkaloids Animals Source Classification	Biochemical Assay Reagents
Formyline (Compound 8) is a Maillard reaction product (glycated compound). Formyline is an advanced glycation end product formed by the reaction of lysine with 3-deoxypentosone, pentose, disaccharide degradation products or glucuronic acid. Formyline is commonly found in heat-processed foods such as milk, baked goods and beer, and can serve as a characteristic marker for food processing .

HY-N1470R

Plantagoside (Standard)	Plantaginaceae Structural Classification Flavonoids Flavonones Phenols Polyphenols Plantago asiatica L. Plants Source Classification	Reference Standards Glycosidase
Plantagoside (Standard) is the analytical standard of Plantagoside (HY-N1470). This product is intended for research and analytical applications. Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

Cat. No.	Product Name	Chemical Structure

HY-113354S

Anserine-d4
Anserine-d₄ is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-W018772S15

D-Ribose(mixture of isomers)-13C5

D-Ribose(mixture of isomers)- ¹³C₅ isomers)- ¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers) . D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner .

HY-Y0785S

Glyoxal-d2
Glyoxal-d₂ is the deuterium labeled Glyoxal (HY-Y0785). Glyoxal is a cytotoxic α-oxoaldehyde. Glyoxal induces cell damage and promotes protein glycation to form advanced glycation end-products (AGEs). Glyoxal is promising for research of oxidative stress-related diseases (such as atherosclerosis, cataract, Alzheimer's disease), and the formation of calcium oxalate kidney stones .

HY-50682S

Azeliragon-d9
Azeliragon-d₉ (TTP488-d₉) is the deuterium labeled Azeliragon (HY-50682). Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression with mild Alzheimer’s disease (AD) . Azeliragon also can cross the blood-brain barrier (BBB) .

HY-113354S1

Anserine-d4 hydrochloride

Anserine-d₄ hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .

HY-W018772S16

D-Ribose-1,2-13C2

D-Ribose-1,2- ¹³C₂ is the ¹³C labled D-Ribose(mixture of isomers) (HY-W018772) . D-Ribose(mixture of isomers) is an energy enhancer，and acts as a sugar moiety of ATP，and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation，induces NF-κB inflammation in a RAGE-dependent manner .

HY-B1392S

Esmolol-d7 hydrochloride

Esmolol-d₇ hydrochloride is the deuterium labeled Esmolol hydrochloride (HY-B1392). Esmolol hydrochloride is an ultra-short-acting cardioselective β1-adrenergic blocker. Esmolol hydrochloride exerts its antiarrhythmic effect by activating Neurokinin 1 Receptoraldose reductase) and the production of advanced glycation end products and promoting fibroblast migration. Esmolol hydrochloride can be used to study cardiac diseases such as arrhythmias and diabetic foot ulcers .

HY-114883BS

Homocarnosine-15N3 TFA

Homocarnosine- ¹⁵N₃ (L-Homocarnosine- ¹⁵N₃) TFA is the ¹⁵N-labeled Homocarnosine (HY-114883). Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) mIHC (1) IF-Tissue (1) IHC-F (1) WB (2) FC (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81086

	RAGE Antibody Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen; LE-9211-A antigen; MGC22357; MOK; RAGE 1; RAGE1; MOK protein kinase; Receptor for advanced glycation endproducts; Renal tumor antigen 1; Renal tumor antigen; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; RAGE_HUMAN.	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse, Rat
	RAGE Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to RAGE.

HY-P81086A

	RAGE Antibody(YA3549) Advanced glycosylation end product specific receptor; Advanced glycosylation end product-specific receptor; AGER; EC 2.7.11.22; LE 9211 A antigen; LE-9211-A antigen; MGC22357; MOK; RAGE 1; RAGE1; MOK protein kinase; Receptor for advanced glycation endproducts; Renal tumor antigen 1; Renal tumor antigen; Renal cell carcinoma antigen (MOK protein kinase); Renal tumor antigen 1; RAGE_HUMAN.	WB, IHC-P, IF-Tissue, mIHC	Human, Mouse, Rat
	RAGE Antibody(YA3549) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAGE.

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