1937-19-5
Chemical Structure
Aminoguanidine hydrochloride
Synonym(s): Pimagedine hydrochloride; GER-11; Aminoguanidinium hydrochloride
- CAS No.: 1937-19-5
- Formula:CH7ClN4
- Molecular Weight:110.55
IUPAC Name: hydrazinecarboximidamide hydrochloride
InChIKey: UBDZFAGVPPMTIT-UHFFFAOYSA-N
SMILES: NNC(N)=N.Cl
Biological Activity: Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Aminoguanidine hydrochloride | 98.0% | Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy. | ||||||||||||||||||||
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Aminoguanidine hydrochloride (Standard) | ≥98% | Aminoguanidine (hydrochloride) (Standard) is the analytical standard of Aminoguanidine (hydrochloride). This product is intended for research and analytical applications. Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research. | ||||||||||||||||||||
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Similarity Score 0.94
HY-B1041AAminoguanidine -
Similarity Score 0.94
HY-B1041ASAminoguanidine-13C, 15N4 -
Similarity Score 0.80
HY-W067028SSemicarbazide-13C,15N2 hydrochloride -
Similarity Score 0.80
HY-Y0470Semicarbazide hydrochloride -
Similarity Score 0.80
HY-W005028R1-Methylguanidine monohydrochloride (Standard) -
Similarity Score 0.78
HY-B0178ARGuanidine hydrochloride (Standard) -
Similarity Score 0.78
HY-B0178ASGuanidine-13C,15N3 hydrochloride -
Similarity Score 0.78
HY-B0178AS2Guanidine-13C hydrochloride -
Similarity Score 0.78
HY-W710540Guanidine-15N3 hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Sabuncuoglu S. Antiapoptotic effect of aminoguanidine on doxorubicin-induced apoptosis. Mol Cell Biochem. 2014 Sep;394(1-2):129-35. [Content Brief]
- [2]. Chowdhury P. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line. Ann Clin Lab Sci. 2017 Sep;47(5):572-580. PMID: 29066484. [Content Brief]
- [3]. Al-Shabanah OA, et al. Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci. 2000;66(3):265-70. [Content Brief]
- [4]. Abraham P, et al. Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats. Redox Rep. 2011;16(1):8-14. [Content Brief]
- [5]. Zou Z, et al. Inhibition of Gli1 suppressed hyperglycemia-induced meibomian gland dysfunction by promoting pparγ expression. Biomed Pharmacother. 2022 Jul;151:113109. [Content Brief]
