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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
22 Results for "
glycosylation sites
" in MedChemExpress (MCE) Product Catalog:
Products (22)
22 Results for "glycosylation sites" in MCE Product Catalog:
3
Category:
Flavonoids Monophenols Flavones Labiatae Phenols Plants Disease Research Fields Medicago truncatula Gaertn. Inflammation/Immunology
Target:
1
1 Cited Publications
Cat. No.: HY-KE7057
O-Glycosidase is highly specific and can release Galβ1-3GalNAc from serine, threonine residues or as part of a glycopeptide or glycoprotein. Applied to glycoprotein biosynthesis analysis, O-glycan bioactive protein O-glycosylation detection and binding site analysis.
Cat. No.: HY-NP0196
Synonyms: Mouse IgG
Cat. No.: HY-NP163D
Synonyms: WGA-AF594
Cat. No.: HY-NP163E
Synonyms: WGA-AF647
Research Areas:
Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .
Cat. No.: HY-P2929B
CAS No.: 83534-39-8
Target:
Research Areas:
PNGase F (Immobilized, Microspin) is a resin in which PNGase F (peptide N-glycosidase F) is covalently coupled to agarose beads, and it is used to remove N-glycans from antibodies, fusion proteins and other N-glycosylated proteins. The enzyme is recombinantly expressed in Escherichia coli, with its sequence derived from Flavobacterium meningsepticum .
Cat. No.: HY-NP163
Synonyms: WGA-AF350
Cat. No.: HY-176559
CAS No.: 2823367-88-8
Cat. No.: HY-NP163J
Synonyms: WGA-AF 405
Cat. No.: HY-NP163I
Synonyms: WGA-AF 680
Cat. No.: HY-177787A
Target:
Research Areas:
2'-Deoxy-N-methyl-AMP ammonium is an N6-substituted adenine nucleotide derivative and a glycosyl donor. On one hand, 2'-Deoxy-N-methyl-AMP ammonium acts as a specific substrate for N6-methyl-AMP aminohydrolase, and it is catalytically converted to dIMP to participate in the nucleotide metabolic cycle. On the other hand, 2'-Deoxy-N-methyl-AMP ammonium also serves as a guanosine diphosphate (GDP)-linked fucose derivative donor, driving site-specific glycoconjugation of proteins under the mediation of α-1,3-fucosyltransferase. 2'-Deoxy-N-methyl-AMP ammonium is an important molecular tool for investigating the mechanisms of nucleotide modification and protein glycosylation .
Cat. No.: HY-NP163H
Synonyms: WGA-AF750
Cat. No.: HY-P4027
CAS No.: 290362-31-1
Cat. No.: HY-P4027A
Cat. No.: HY-E70568
Target:
Research Areas:
Protease (O-glycan Cleaving) is recombinantly expressed from E.coli and contains a His tag. Protease (O-glycan Cleaving) is an O-glycan-dependent protease that digests proteins carrying mucin-type O-glycans, including sialylated substrates, glycosylated Ser and Thr residues at the N terminus. Protease (O-glycan Cleaving) digests a variety of O-glycan structures, including sialylated glycosylated core 1 and core 2 structures and Tn antigen. Protease (O-glycan Cleaving) does not digest terminally modified serine or threonine residues, nor does it digest N-glycosylation sites on glycoproteins.
Cat. No.: HY-180467A
Target:
Research Areas:
Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me (Compound G12) sodium is a disaccharide linker. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium can be efficiently recognized by the endo-glycosidase Endo-S2 and can be directedly transferred to the conserved N-glycosylation site (Asn297 position) of the antibody's Fc domain through enzymatic catalytic reactions, thereby achieving site-specific modification of the antibody. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me sodium can be used for for the synthesis of antibody-conjugated drugs (ADCs) .
Cat. No.: HY-Y2043
CAS No.: 3080790-02-6
Target:
Research Areas:
DiAz-LacNAc-Oxa is an ADC linker. This linker contains a disaccharide linker structure for glyco-site specific glycosylation coupling, and an asymmetric biazide group for subsequent click reactions.
Cat. No.: HY-E70069A
Target:
Research Areas:
Endo S2 (MS grade) is an IgG-specific endo glycosidase that can hydrolyze the complex N-glycans at the Fc N-glycosylation sites. Endo S2 (MS grade) can hydrolyze the glycosylation modifications following the core GlcNAc of IgG, but its activity is limited for high-mannose type and mixed-type glycans.
Cat. No.: HY-NP163B
Synonyms: WGA-AF532
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
