727664-79-1
727664-79-1
Chemical Structure
Thr101
- CAS No.: 727664-79-1
- Formula:C14H10FNOS
- Molecular Weight:259.30
IUPAC Name: 6-fluoro-2-(o-tolyl)benzo[d]isothiazol-3(2H)-one
InChIKey: BUIZTXXZBDUOCR-UHFFFAOYSA-N
SMILES: O=C1N(SC2=CC(F)=CC=C12)C3=CC=CC=C3C
Biological Activity: Thr101 is a selective phosphomannose isomerase (PMI) inhibitor with an IC50 of 2.9 µM. Thr101 inhibits PMI, which converts mannose-6-phosphate to fructose-6-phosphate and competes with PMM2 for mannose-6-phosphate. Thr101 can be used in research on congenital disorders of glycosylation type Ia (CDG-Ia)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Thr101 | 99.48% | Thr101 is a selective phosphomannose isomerase (PMI) inhibitor with an IC50 of 2.9 µM. Thr101 inhibits PMI, which converts mannose-6-phosphate to fructose-6-phosphate and competes with PMM2 for mannose-6-phosphate. Thr101 can be used in research on congenital disorders of glycosylation type Ia (CDG-Ia). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.85
HY-112945MLS0315771 -
Similarity Score 0.76
HY-138802ML089 -
Similarity Score 0.73
HY-101451PBIT -
Similarity Score 0.70
HY-128170Ebsulfur -
Similarity Score 0.70
HY-157145SARS-CoV-2-IN-69 -
Similarity Score 0.66
HY-124044ML 086 -
Similarity Score 0.64
HY-124696PU139 -
Similarity Score 0.59
HY-49075WAY-622252 -
Similarity Score 0.58
HY-B1833RAfloqualone (Standard) -
Explore the MedChemAI to find more analogs
