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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

hGPR39-2 cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GPR39 (3) HIV (1) ROR (1)
By Research Areas:	Infection (1) Inflammation/Immunology (3) Metabolic Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137255

Taurolithocholic acid 3-sulfate disodium 3-Sulfotaurolithocholic acid disodium	GPR39	Inflammation/Immunology
Taurolithocholic acid 3-sulfate disodium is a *GPR39* agonist with EC₅₀s of 71.6  and 69.4 (absence of Zn ²⁺) and 9 and 9.6 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease .

HY-113238A

Lithocholic acid 3-sulfate disodium Sulfolithocholic acid disodium; LCAS disodium	GPR39 ROR	Metabolic Disease Inflammation/Immunology
Lithocholic acid 3-sulfate disodium is a *GPR39* agonist, with EC₅₀ values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn ²⁺, and 0.88 μM and 0.97 μM in the presence of Zn ²⁺. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn ²⁺-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .

HY-W587430

Glycolithocholic acid 3-sulfate disodium Glycolithocholate sulfate disodium; Sulfolithocholylglycine disodium; SLCG disodium	HIV GPR39	Infection Inflammation/Immunology
Glycolithocholic acid 3-sulfate disodium is a *GPR39* agonist with EC₅₀s of 47.9  and 66.8 μM (absence of Zn ²⁺) and 8 and 8.7 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Glycolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Glycolithocholic acid 3-sulfate disodium also inhibits replication of HIV-1 in vitro. Glycolithocholic acid 3-sulfate disodium can be used for the research of HIV infection and gallbladder disease .

Cat. No.	Product Name	Type

HY-137255

Taurolithocholic acid 3-sulfate disodium 3-Sulfotaurolithocholic acid disodium	Biochemical Assay Reagents
Taurolithocholic acid 3-sulfate disodium is a *GPR39* agonist with EC₅₀s of 71.6  and 69.4 (absence of Zn ²⁺) and 9 and 9.6 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease .

Taurolithocholic acid 3-sulfate disodium

3-Sulfotaurolithocholic acid disodium

Biochemical Assay Reagents

Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC₅₀s of 71.6  and 69.4 (absence of Zn ²⁺) and 9 and 9.6 μM (presence of Zn ²⁺) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn ²⁺ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease .

HY-113238A

Lithocholic acid 3-sulfate disodium Sulfolithocholic acid disodium; LCAS disodium	Biochemical Assay Reagents
Lithocholic acid 3-sulfate disodium is a *GPR39* agonist, with EC₅₀ values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn ²⁺, and 0.88 μM and 0.97 μM in the presence of Zn ²⁺. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn ²⁺-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .

Lithocholic acid 3-sulfate disodium

Sulfolithocholic acid disodium; LCAS disodium

Biochemical Assay Reagents

Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC₅₀ values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn ²⁺, and 0.88 μM and 0.97 μM in the presence of Zn ²⁺. Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn ²⁺-binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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