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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
hepatic damage
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "hepatic damage" in MCE Product Catalog:
34
Category:
Human Gut Microbiota Metabolites Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids
Target:
34
34 Publications Verification
Synonyms: Sodium taurocholate; N-Choloyltaurine sodium
Target:
34
34 Publications Verification
Cat. No.: HY-B1131
CAS No.: 345909-26-4
Synonyms: Sodium taurocholate hydrate; N-Choloyltaurine sodium salt hydrate
Target:
11
Research Areas:
GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways .
3
Category:
Microorganisms Vitis vinifera cv. Zalema Plants Vitaceae Disease Research Fields Inflammation/Immunology Saccharides Monosaccharides
Target:
2
2 Cited Publications
Synonyms: Bisacrylamide; MBA; Methylenebisacrylamide; N,N-Methylenebisacrylamide
1
1 Cited Publications
Cat. No.: HY-N3121
CAS No.: 33708-72-4
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-N0909
CAS No.: 80418-25-3
Synonyms: 20(S)-Notoginsenoside R2; Ginsenoside Ng-R2
1
Category:
Cardiovascular Disease Triterpenes other families Terpenoids Plants Disease Research Fields
Target:
Cat. No.: HY-P10302A
Target:
Research Areas:
Target:
Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis
Research Areas:
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .
Cat. No.: HY-N0688
CAS No.: 13476-25-0
Synonyms: Sodium taurocholate (Standard); N-Choloyltaurine sodium (Standard)
Cat. No.: HY-N12124
CAS No.: 1011244-19-1
Synonyms: Monascinol
Cat. No.: HY-W019704
CAS No.: 1115-47-5
Target:
Synonyms: ADX-629
Target:
Research Areas:
Acloproxalap (ADX-629) is an orally active reactive aldehyde species (RASP) inhibitor. Acloproxalap binds covalently to free aldehydes, sequesters reactive aldehyde species, malondialdehyde, acetaldehyde and preformed malondialdehyde-acetaldehyde adducts, and reduces elevated RASP levels. Acloproxalap decreases the formation of aldehyde adducts, reduces liver and serum triglyceride levels, hepatic fat accumulation, circulating anti-malondialdehyde-acetaldehyde adduct antibody levels, and inhibits the release of IL-6 and MCP-1. Acloproxalap improves cell viability of liver slices exposed to ethanol. Acloproxalap blocks ethanol-induced damage in animal models of alcoholic liver disease. Acloproxalap is applicable to research related to alcoholic liver disease, alcoholic fatty liver disease, non-alcoholic steatohepatitis, chronic cough, rheumatoid arthritis, ulcerative colitis and mild atopic asthma .
Cat. No.: HY-N1506
CAS No.: 106518-63-2
Category:
Other Terpenoids Human Gut Microbiota Metabolites Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite Disease Research Fields Cancer
Target:
Cat. No.: HY-156065
CAS No.: 2700303-28-0
Research Areas:
S217879 is an orally active and selective NRF2 activator. S217879 activates the NRF2 pathway by specifically disrupting the KEAP1 (Kd: 4.15 nM)-NRF2 interaction, and upregulates the antioxidant response. S217879 also ameliorates steatohepatitis and reduces the degree of liver fibrosis. S217879 can be used in the research of metabolic dysfunction-associated steatotic liver disease and nonalcoholic steatohepatitis .
Cat. No.: HY-W653842
CAS No.: 1351996-69-4
Synonyms: Sodium taurocholate-d8 (Standard); N-Choloyltaurine-d8 sodium
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
