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Results for "

hepatic necrosis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminotransferases (Transaminases) (1) Apoptosis (8) Bcl-2 Family (1) Biochemical Assay Reagents (1) Cytochrome P450 (2) DNA/RNA Synthesis (3) Endogenous Metabolite (4) Environmental Pollutants (1) Histamine Receptor (1) Mixed Lineage Kinase (1) MMP (1) Monoamine Oxidase (4) Necroptosis (4) NO Synthase (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Reference Standards (5) TGF-beta/Smad (1) Thrombin (1) Topoisomerase (3) VEGFR (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Endocrinology (4) Inflammation/Immunology (8) Metabolic Disease (8) Neurological Disease (6)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Natural
Products

Oligonucleotides

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1788

Taurocholic acid Maximum Cited Publications 31 Publications Verification N-Choloyltaurine	Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .

HY-N0545

Taurocholic acid sodium Maximum Cited Publications 31 Publications Verification Sodium taurocholate; N-Choloyltaurine sodium	VEGFR Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

HY-W010800

Cholesteryl hemisuccinate	Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Cancer
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and *necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase* and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

HY-W010800A

Cholesterol hemisuccinate Tris salt Cholesterol hydrogen succinate Tris salt; CHS-Tris	Biochemical Assay Reagents Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Inflammation/Immunology Cancer
Cholesterol hemisuccinate (Cholesterol hydrogen succinate) Tris salt is a compound with hepatoprotective and anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP) (HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and *necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase* and DNA topoisomerase to inhibit DNA replication and repair and cell division. Cholesterol hemisuccinate Tris salt inhibits tumor growth. Cholesterol hemisuccinate Tris salt can be used for buffer preparation .

HY-122515

Fulvic Acid 1 Publications Verification	Others	Metabolic Disease Inflammation/Immunology
Fulvic Acid is a natural product, which comes from humic substances produced by microorganisms in soil. Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function. Fulvic Acid has the potential for researching chronic inflammatory diseases, including diabetes .

HY-B0886A

Iproniazid 2 Publications Verification	Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Endocrinology
Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity .

HY-B1483

Methapyrilene hydrochloride Thenylpyramine hydrochloride	Environmental Pollutants Histamine Receptor	Inflammation/Immunology
Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo

HY-B0886

Iproniazid phosphate 2 Publications Verification	Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Endocrinology
Iproniazid phosphate is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid phosphate inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid phosphate modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid phosphate can be used in the research of depression, Parkinson's disease, and hepatotoxicity .

HY-N0545R

Taurocholic acid sodium (Standard) 5+ Cited Publications Sodium taurocholate (Standard); N-Choloyltaurine sodium (Standard)	Reference Standards VEGFR Endogenous Metabolite	Inflammation/Immunology
Taurocholic acid (sodium) (Standard) is the analytical standard of Taurocholic acid (sodium). This product is intended for research and analytical applications. Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

HY-156119

MLKL-IN-6	Mixed Lineage Kinase Necroptosis	Metabolic Disease Cancer
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL). MLKL-IN-6 inhibits cell necrosis. MLKL-IN-6 inhibits MLKL phosphorylation and oligomerization during cell necrosis, inhibits immune cell death, and reduces the expression of adhesion factors. MLKL-IN-6 has low cytotoxicity, and it inhibits hepatic stellate cell activation, reduces liver fibrosis marker levels, and has anti-fibrotic effects .

HY-W010800R

Cholesteryl hemisuccinate (Standard)	Reference Standards Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis	Cancer
Cholesteryl hemisuccinate (Standard) is the analytical standard of Cholesteryl hemisuccinate. This product is intended for research and analytical applications. Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].

HY-B1788R

Taurocholic acid (Standard) N-Choloyltaurine (Standard)	Reference Standards Endogenous Metabolite	Inflammation/Immunology
Taurocholic acid (Standard) is the analytical standard of Taurocholic acid. This product is intended for research and analytical applications. Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .

HY-174285

NAPAP	Thrombin	Cardiovascular Disease
NAPAP is a selective direct thrombin inhibitor. NAPAP rapidly binds to thrombin and inhibits its activity, and reduces LPS (HY-D1056)-induced brain inflammation and coagulation factor expression in vivo. NAPAP can be used in studies related to coagulation and neuroinflammation .

HY-N16478

Echihumiline	Cytochrome P450	Metabolic Disease
Echihumiline is an alkaloid targeting hepatic cytochrome P450 enzymes (CYP450). Echihumiline induces DNA cross-linking and oxidative stress in hepatocytes, leading to liver necrosis and fibrosis. Echihumiline is promising for research of liver diseases .

HY-106417

Limazocic SA 3443	Phosphatase Aminotransferases (Transaminases)	Metabolic Disease
Limazocic (SA 3443) is an orally active hepatoprotective agent. Limazocic can inhibit increases in serum transaminase, alkaline phosphatase activity and hepatic lipids, hydroxyproline content induced by CCl4. Limazocic can decrease the degree of hepatic necrosis, fibrosis and steatosis. Limazocic can be used for the research of chronic liver injuries .

HY-N13208

Stevia Powder	MMP TGF-beta/Smad	Others
Stevia Powder is a natural sweetener with antioxidant activity. Stevia Powder can downregulate pro fibrotic pathways in cirrhotic rats, including reduced hepatic myofibroblasts and decreased expression of matrix metalloproteinases MMP2 and MMP13, upregulate anti fibrotic molecule Smad7, prevent serum necrosis and elevated bile stasis markers, thereby inhibiting the development of liver fibrosis .

HY-B0886AR

Iproniazid (Standard)	Reference Standards Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Endocrinology
Iproniazid (Standard) is the analytical standard of Iproniazid (HY-B0886A). This product is intended for research and analytical applications. Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity .

HY-N1500A

(S)-Pulegone (-)-Pulegone	Cytochrome P450	Cancer
(S)-Pulegone ((-)-Pulegone) is a cytochrome P450 (CYP450) substrate. (S)-Pulegone induces urothelial cytotoxicity, necrosis, regenerative proliferation and urinary bladder tumors in female rats. (S)-Pulegone induces rodent nephropathy, olfactory metaplasia, gastric hyperplasia/perforation at high dose. (S)-Pulegone can be used for the research of urinary bladder and hepatic neoplasms .

HY-B0886R

Iproniazid phosphate (Standard)	Reference Standards Monoamine Oxidase Apoptosis	Neurological Disease Metabolic Disease Endocrinology
Iproniazid (phosphate) (Standard) is the analytical standard of Iproniazid phosphate (HY-B0886). This product is intended for research and analytical applications. Iproniazid phosphate is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid phosphate inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid phosphate modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid phosphate can be used in the research of depression, Parkinson's disease, and hepatotoxicity .

HY-182060

PDE4B/D-IN-5	Phosphodiesterase (PDE) Bcl-2 Family NO Synthase Apoptosis	Inflammation/Immunology
PDE4B/D-IN-5 (Compound P32) is a peripherally restricted, oral active inhibitor of PDE4B and PDE4D with extremely low blood-brain barrier penetration, with IC₅₀ values of 3.4 nM and 2.2 nM, respectively. PDE4B-IN-8 inhibits the production of TNF-α. PDE4B/D-IN-5 significantly reduces the Bax/Bcl2 ratio, and alleviates oxidative stress by decreasing MPO activity and NO levels. PDE4B/D-IN-5 exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities. PDE4B/D-IN-5 can be used for the research of acute lung injury .

Taurocholic acid Maximum Cited Publications 31 Publications Verification N-Choloyltaurine	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .

Taurocholic acid sodium Maximum Cited Publications 31 Publications Verification Sodium taurocholate; N-Choloyltaurine sodium	Structural Classification Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	VEGFR Endogenous Metabolite
Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

Fulvic Acid 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Others
Fulvic Acid is a natural product, which comes from humic substances produced by microorganisms in soil. Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function. Fulvic Acid has the potential for researching chronic inflammatory diseases, including diabetes .

Taurocholic acid sodium (Standard) 5+ Cited Publications Sodium taurocholate (Standard); N-Choloyltaurine sodium (Standard)	Structural Classification Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Reference Standards VEGFR Endogenous Metabolite
Taurocholic acid (sodium) (Standard) is the analytical standard of Taurocholic acid (sodium). This product is intended for research and analytical applications. Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect .

Taurocholic acid (Standard) N-Choloyltaurine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Taurocholic acid (Standard) is the analytical standard of Taurocholic acid. This product is intended for research and analytical applications. Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect .

Echihumiline	Pyrrolizidine Alkaloids Structural Classification Alkaloids Plants Boraginaceae Echium humile Desf. Source Classification	Cytochrome P450
Echihumiline is an alkaloid targeting hepatic cytochrome P450 enzymes (CYP450). Echihumiline induces DNA cross-linking and oxidative stress in hepatocytes, leading to liver necrosis and fibrosis. Echihumiline is promising for research of liver diseases .

(S)-Pulegone (-)-Pulegone	Structural Classification Natural Products Glycyrrhiza aspera Pall. Labiatae Plants Source Classification	Cytochrome P450
(S)-Pulegone ((-)-Pulegone) is a cytochrome P450 (CYP450) substrate. (S)-Pulegone induces urothelial cytotoxicity, necrosis, regenerative proliferation and urinary bladder tumors in female rats. (S)-Pulegone induces rodent nephropathy, olfactory metaplasia, gastric hyperplasia/perforation at high dose. (S)-Pulegone can be used for the research of urinary bladder and hepatic neoplasms .

Cat. No.	Product Name		Classification

HY-W010800

Cholesteryl hemisuccinate		Cholesterol
Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and *necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase* and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .

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hepatic necrosis

Inhibitors & Agonists

NaturalProducts

Oligonucleotides

Natural
Products