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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
host toxicity
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "host toxicity" in MCE Product Catalog:
8
Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .
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8 Publications Verification
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Research Areas:
2
2 Cited Publications
Anguizole is an HCV NS4B inhibitor. Anguizole interacts with NS4B-AH2, inhibits AH2 lipid vesicle aggregation, disrupts NS4B dimerization/multimerization and impairs NS4B-NS5A interaction. Anguizole exhibits little host cell toxicity. Anguizole can be used for the research of HCV infection .
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1 Cited Publications
Target:
Free Radical Scavengers TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species (ROS)
Research Areas:
NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .
Category:
Infection Monophenols Leguminosae Terpenoids Phenols Diterpenoids Plants Sophora flavescens Aiton Disease Research Fields
Target:
Cat. No.: HY-P991224
Target:
Research Areas:
Cat. No.: HY-B0223R
CAS No.: 54965-21-8
Synonyms: SKF-62979 (Standard)
Albendazole (Standard) is the analytical standard of Albendazole. This product is intended for research and analytical applications. Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells .
Cat. No.: HY-121473
CAS No.: 60504-57-6
Target:
Research Areas:
Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene .
Cat. No.: HY-134922
CAS No.: 181373-35-3
Synonyms: REDD1 inducer-1
Target:
Research Areas:
NS1-IN-1 (REDD1 inducer-1) is a naphthalimide compound and an NS1 inhibitor. NS1-IN-1 antagonizes influenza A virus NS1-mediated inhibition of host gene expression and induces REDD1 expression. NS1-IN-1 suppresses the mTORC1 signaling pathway via a TSC1-TSC2 dependent mechanism. NS1-IN-1 exhibits broad antiviral activity against influenza virus and vesicular stomatitis virus (VSV), with low toxicity .
Cat. No.: HY-177059
CAS No.: 65199-10-2
Synonyms: NBMPR-P
Target:
Research Areas:
Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P), a nucleoside analog, is a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate blocks nucleoside transport in vivo and prevents host toxicity in tumor-bearing mice administered with highdoses of Tubercidin (HY-100126) .
Cat. No.: HY-B0223S2
CAS No.: 1287076-43-0
Synonyms: SKF-62979-d7
Cat. No.: HY-106129
CAS No.: 176975-26-1
Synonyms: LY 320236
Target:
Research Areas:
Izonsteride (Compound LY320236) is an inhibitor of 5α-reductase (IC50 = 11.6 nM for type I; 7.37 nM for type II). LY320236 inhibits the activity of steroid 5α-reductase, preventing the conversion of testosterone (T) to dihydrotestosterone (DHT). LY320236 can significantly inhibit the growth of LNCaP tumors in thymic mice without exhibiting obvious host toxicity .
Cat. No.: HY-B0223S4
Synonyms: SKF-62979-d3-1
Cat. No.: HY-N21835
CAS No.: 11096-49-4
Category:
Target:
Cat. No.: HY-180791
SARS-CoV-2-IN-121 (Compound 74) is a SARS-CoV-2 virus inhibitor. SARS-CoV-2-IN-121 exhibits IC50 values in the pseudovirus and live virus systems of 1.6 and 0.45 μM respectively. SARS-CoV-2-IN-121 effectively inhibits the replication or protein expression of the virus within cells and has almost no toxicity to host cells. SARS-CoV-2-IN-121 can be used for SARS-CoV-2 virus infection research .
Cat. No.: HY-W743773
CAS No.: 76703-62-3
Target:
Research Areas:
γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research .
Cat. No.: HY-L219
58 compounds
Antimicrobial Peptides (AMPs), also known as antimicrobial peptides or antibiotic peptides, are a class of polypeptides encoded by specific genes in various biological cells and induced by external stimuli. They exhibit broad-spectrum bioactivity against bacteria, fungi, viruses, protozoa, and even tumor cells. AMPs serve as crucial effector molecules in the host's innate immune system.Due to their wide antimicrobial spectrum, low toxicity to normal cells of higher animals, high safety profile, low tendency to induce resistance, and additional benefits such as immune enhancement and antioxidant effects, antimicrobial peptides hold significant promise in new drug development.
MCE offers 58 types of antimicrobial peptides, which can be applied in high-throughput screening for research in anti-infection therapies, immunotherapy, anticancer drug development, and agricultural disease control.
Cat. No.: HY-L073
394 compounds
Hepatitis C virus (HCV) is a hepatotropic enveloped positive- strand RNA virus (family Flaviviridae) that infects the parenchymal cells of the liver. HCV infection is a significant public health burden. Globally, an estimated 71 million people have chronic hepatitis C virus infection. A significant number of those who are chronically infected will develop cirrhosis or liver cancer. To date, there is no vaccine against HCV, and combination pegylated alpha interferon (pIFN-) and ribavirin, the main standard-of-care treatment for HCV, is effective in only a subset of patients and is associated with a wide spectrum of toxic side effects and complications. More recently, new therapeutic approaches that target essential components of the HCV life cycle have been developed, including direct-acting antiviral (DAA) that specifically block a viral enzyme or functional protein and host-targeted agents (HTA) that block interactions between host proteins and viral components that are essential to the viral life cycle. However, the genetic diversity of HCV viruses and the stage of liver disease (i.e., cirrhosis) are revealing themselves as obstacles for effective, pan-genotypic treatments. There still exists a need for the discovery and development of new HCV inhibitors. In particular, since the future of HCV therapy will likely consist of a cocktail approach using multiple inhibitors that target different steps of infection, new antivirals targeting all steps of the viral infection cycle.
MCE offers a unique collection of 394 compounds with identified and potential anti-HCV activity. MCE Anti- Hepatitis C Virus Compound Library is a useful tool for discovery new anti-HCV drugs and other anti-infection research.
Cat. No.: HY-L076
641 compounds
Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.
DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.
MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 641 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
