65199-10-2
Chemical Structure
Nitrobenzylthioinosine 5'-monophosphate
Synonym(s): NBMPR-P
- CAS No.: 65199-10-2
- Formula:C17H18N5O9PS
- Molecular Weight:499.39
InChIKey: RMYYPCIAJWYVHZ-LSCFUAHRSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N(C=N2)C3=C2C(SCC4=CC=C([N+]([O-])=O)C=C4)=NC=N3
Biological Activity: Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) is a nucleoside analog and a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate in combination with Tubercidin (HY-100126) protects mice or hematopoietic progenitor cells from the lethality of Tubercidin. Nitrobenzylthioinosine 5'-monophosphate can be used in research on schistosomiasis and leukemia L1210[1][2][3][4][5].
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Nitrobenzylthioinosine 5'-monophosphate | Nitrobenzylthioinosine 5'-monophosphate (NBMPR-P) is a nucleoside analog and a prodrug of the potent nucleoside transport inhibitor Nitro-benzylthioinosine (NBMPR) (HY-W010936). Nitrobenzylthioinosine 5'-monophosphate in combination with Tubercidin (HY-100126) protects mice or hematopoietic progenitor cells from the lethality of Tubercidin. Nitrobenzylthioinosine 5'-monophosphate can be used in research on schistosomiasis and leukemia L1210. | |||||||||||||||||||||
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References
- [1]. el Kouni MH, et al. Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. Antimicrobial agents and chemotherapy. 1989 Jun;33(6):824-7. [Content Brief]
- [2]. Kolassa N, et al. Modification by nitrobenzylthioinosine-5'-monophosphate of pseudoisocytidine pharmacokinetics in mice and rats through inhibition of membrane transport. Cancer Treat Rep. 1983 Jan;67(1):51-8.
- [3]. el Kouni MH, et al. Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'-monophosphate against chronic and advanced stages of schistosomiasis. Biochemical pharmacology. 1991 Mar 01;41(5):815-20.
- [4]. Lynch TP, et al. Therapy of mouse leukemia L1210 with combinations of nebularine and nitrobenzylthioinosine 5'-monophosphate. Cancer research. 1981 Feb;41(2):560-5.
- [5]. Miller SR, et al. Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters. Pharmacology research & perspectives. 2021 Aug;9(4):e00831.
