442666-98-0
Chemical Structure
Anguizole
- CAS No.: 442666-98-0
- Formula:C17H11ClF2N4O2S
- Molecular Weight:408.81
IUPAC Name: 7-(chlorodifluoromethyl)-5-(furan-2-yl)-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
InChIKey: GBNREAYNZPJROB-UHFFFAOYSA-N
SMILES: FC(Cl)(C1=CC(C2=CC=CO2)=NC3=CC(C(NCC4=CC=CS4)=O)=NN31)F
Biological Activity: Anguizole is an HCV NS4B inhibitor. Anguizole interacts with NS4B-AH2, inhibits AH2 lipid vesicle aggregation, disrupts NS4B dimerization/multimerization and impairs NS4B-NS5A interaction. Anguizole exhibits little host cell toxicity. Anguizole can be used for the research of HCV infection[1][2][3].
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Anguizole | 99.53% | Anguizole is an HCV NS4B inhibitor. Anguizole interacts with NS4B-AH2, inhibits AH2 lipid vesicle aggregation, disrupts NS4B dimerization/multimerization and impairs NS4B-NS5A interaction. Anguizole exhibits little host cell toxicity. Anguizole can be used for the research of HCV infection. | ||||||||||||||||||||
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- [1]. Bryson PD, et al. A small molecule inhibits HCV replication and alters NS4B's subcellular distribution. Antiviral Res. 2010;87(1):1-8. [Content Brief]
- [2]. Choi M, et al. A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A. Virus Genes. 2013;47(3):395-407. [Content Brief]
- [3]. Delang L, et al. Hepatitis C virus-specific directly acting antiviral drugs. Curr Top Microbiol Immunol. 2013;369:289-320. [Content Brief]
Keywords
