2 Results for "

influx of Immune cells

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "influx of Immune cells" in MCE Product Catalog:

Cat. No.: HY-13499
CAS No.: 1228650-83-6
Purity:  99.65%
Synonyms: CCR2 antagonist 5
Target:  

CCR

Research Areas:  

Inflammation/Immunology

JNJ-41443532 (CCR2 antagonist 5) is a selective, orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM). JNJ-41443532 displays a Ki of 9.6 µM for mCCR2 binding. JNJ-41443532 can be used in the research of inflammatory disease .
loading...
    loading...
Cat. No.: HY-N2595
CAS No.: 5574-24-3
Synonyms: O-Methylatheroline
Oxoglaucine (O-Methylatheroline) is a natural product with multiple activities including autophagy activation, anti-inflammation, antibacterial activity, and immunoregulation. Oxoglaucine inhibits the TRPV5/calmodulin/CAMK-II pathway, suppresses TGFβ-induced Smad2 phosphorylation by upregulating Smad7, blocks Ca 2+ influx, activates autophagy, alleviates apoptosis and inflammation, inhibits ROS production and the expression of fibrosis markers in hepatocytes, and regulates immune cell populations and responses. Oxoglaucine protects against infections caused by Candida albicans and Klebsiella pneumoniae, and exerts effects on adjuvant-induced arthritis. Oxoglaucine can be used in studies related to arthritis, liver fibrosis, bacterial infections, and fungal infections .
loading...
    loading...